Grayanotoxin: Difference between revisions

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==History and culture==

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The Gurung people of Nepal are especially known to harvest mad honey for its supposed hallucinogenic properties <ref>Shrestha TM, Nepal G, Shing YK, Shrestha L. Cardiovascular, psychiatric, and neurological phenomena seen in mad honey disease: A clinical case report. Clin Case Rep. 2018 Oct 22;6(12):2355-2357. doi: 10.1002/ccr3.1889. PMID: 30564328; PMCID: PMC6293183.</ref>.

==Chemistry==

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===Lethal dosage===

===Tolerance and addiction potential===

===Dangerous interactions===

*'''[[Cholinergics]]''' - Because grayanotoxins potentiate the effects of [[acetylcholine]],

*'''[[UnsafeInteraction::Cholinergics]]''' - Because grayanotoxins potentiate the effects of [[acetylcholine]], cholinergic substances such as [[nicotine]], [[caffeine]], and [[galantamine]] may carry an increased risk of [[cholinergic crisis]].

*'''[[UnsafeInteraction::Depressants]]''' - Combining grayanotoxins with other [[depressants]] increase the risk of a sudden loss of consciousness.

*'''[[DangerousInteraction::Opioids]]''' - Grayanotoxins and opioids potentiate the [[sedation]], [[hypotension]], and [[decreased heart rate]] caused by each other, increasing the risk of sudden loss of consciousness or [[respiratory depression]].

==Legal status==

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-{{decree|type=notice|message=This article is in the 'Talk' namespace because it is an unfinished draft. This section is used to host drafts for unpublished articles as well as discussions for published ones. If you'd like to use this area to discuss this draft, please do so in the 'Discussion' section at the very bottom of the page. This notice will be removed once this draft has been approved for publication by an administrator.}}
-{{headerpanel|{{Approval}}}}
 {{SummarySheet}}
 {{talk:SubstanceBox/Grayanotoxin}}
-<!-- Please ensure that any new substance articles are first published in the 'Talk' namespace. For example, a new article on substance XYZ should have the title "Talk: XYZ" instead of "XYZ". Once the submitted article has been reviewed and determined to meet the guidelines and standards, it will be published by a staff member. -->
-For tips on how to properly format a substance article, please refer to this document: [[Content Style Guide - Substance]]
 ==History and culture==
@@ Line 14: / Line 7: @@
 The Gurung people of Nepal are especially known to harvest mad honey for its supposed hallucinogenic properties <ref>Shrestha TM, Nepal G, Shing YK, Shrestha L. Cardiovascular, psychiatric, and neurological phenomena seen in mad honey disease: A clinical case report. Clin Case Rep. 2018 Oct 22;6(12):2355-2357. doi: 10.1002/ccr3.1889. PMID: 30564328; PMCID: PMC6293183.</ref>.
 ==Chemistry==
@@ Line 104: / Line 95: @@
 ===Lethal dosage===
 ===Tolerance and addiction potential===
 ===Dangerous interactions===
 {{DangerousInteractions}}
 {{DangerousInteractions/Intro}}
-*'''[[Cholinergics]]''' - Because grayanotoxins potentiate the effects of [[acetylcholine]],
+*'''[[UnsafeInteraction::Cholinergics]]''' - Because grayanotoxins potentiate the effects of [[acetylcholine]], cholinergic substances such as [[nicotine]], [[caffeine]], and [[galantamine]] may carry an increased risk of [[cholinergic crisis]].
+*'''[[UnsafeInteraction::Depressants]]''' - Combining grayanotoxins with other [[depressants]] increase the risk of a sudden loss of consciousness.
+*'''[[DangerousInteraction::Opioids]]'''  - Grayanotoxins and opioids potentiate the [[sedation]], [[hypotension]], and [[decreased heart rate]] caused by each other, increasing the risk of sudden loss of consciousness or [[respiratory depression]].
 ==Legal status==
 {{LegalStub}}