Ibotenic acid: Difference between revisions

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'''Ibotenic acid''' or '''(''S'')-2-amino-2-(3-hydroxyisoxazol-5-yl)acetic acid''' (also referred to as '''ibotenate''') is a ~~chemical compound and~~ psychoactive ~~drug~~ which occurs naturally in ''[[Amanita muscaria]]'' and related species of mushrooms. It is ~~a conformationally-restricted~~ analogue of the neurotransmitter [[glutamate]], and due to its structural similarity to this neurotransmitter, acts as a non-selective glutamate receptor agonist. ~~Because of this, ibotenic~~ acid ~~can be~~ a powerful neurotoxin, and is employed as a "brain-lesioning agent" through cranial injections in scientific research.

{{headerpanel|{{stub}}}}

'''Ibotenic acid''' or '''(''S'')-2-amino-2-(3-hydroxyisoxazol-5-yl)acetic acid''' (also referred to as '''ibotenate''') is a psychoactive substance which occurs naturally in ''[[Amanita muscaria]]'' and related species of mushrooms. It is an analogue of the neurotransmitter [[glutamate]], and due to its structural similarity to this neurotransmitter, acts as a non-selective glutamate receptor agonist.{{citation needed}}

Ibotenic acid is a powerful neurotoxin, and has been employed as a "brain-lesioning agent" through cranial injections in scientific research conducted in rats.{{citation needed}} The same properties have not been studied in humans, however it could very well be a human neurotoxin as well.

==Chemistry==

==Pharmacology==

==Subjective effects==

{{effectStub}}The most common symptoms include nausea, vomiting, and drowsiness. However, after the first hour symptoms begin to include confusion, euphoria, visual and auditory distortions, sensations of floating, and retrograde amnesia.

Symptoms are slightly different for children, typically beginning after 30–180 minutes. Dominant symptoms in children include ataxia, obtundation, and lethargy. Seizures are occasionally reported, however, more commonly with children.<ref>{{Citation | year=2022 | title=Ibotenic acid | url=https://en.wikipedia.org/w/index.php?title=Ibotenic_acid&oldid=1095441575}}</ref>

[[Category:Amino acid]]

[[Category:3-Hydroxyisoxazole]]

[[Category:Hallucinogen]]

==References==

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-'''Ibotenic acid''' or '''(''S'')-2-amino-2-(3-hydroxyisoxazol-5-yl)acetic acid''' (also referred to as '''ibotenate''') is a chemical compound and psychoactive drug which occurs naturally in ''[[Amanita muscaria]]'' and related species of mushrooms. It is a conformationally-restricted analogue of the neurotransmitter [[glutamate]], and due to its structural similarity to this neurotransmitter, acts as a non-selective glutamate receptor agonist. Because of this, ibotenic acid can be a powerful neurotoxin, and is employed as a "brain-lesioning agent" through cranial injections in scientific research.
+{{headerpanel|{{stub}}}}
+{{SubstanceBox/Ibotenic acid}}
+'''Ibotenic acid''' or '''(''S'')-2-amino-2-(3-hydroxyisoxazol-5-yl)acetic acid''' (also referred to as '''ibotenate''') is a psychoactive substance which occurs naturally in ''[[Amanita muscaria]]'' and related species of mushrooms. It is an analogue of the neurotransmitter [[glutamate]], and due to its structural similarity to this neurotransmitter, acts as a non-selective glutamate receptor agonist.{{citation needed}}
+Ibotenic acid is a powerful neurotoxin, and has been employed as a "brain-lesioning agent" through cranial injections in scientific research conducted in rats.{{citation needed}} The same properties have not been studied in humans, however it could very well be a human neurotoxin as well.
+==Chemistry==
+{{chemistry}}
+==Pharmacology==
+{{pharmacology}}
+==Subjective effects==
+{{effectStub}}The most common symptoms include nausea, vomiting, and drowsiness. However, after the first hour symptoms begin to include confusion, euphoria, visual and auditory distortions, sensations of floating, and retrograde amnesia.
+Symptoms are slightly different for children, typically beginning after 30–180 minutes. Dominant symptoms in children include ataxia, obtundation, and lethargy. Seizures are occasionally reported, however, more commonly with children.<ref>{{Citation | year=2022 | title=Ibotenic acid | url=https://en.wikipedia.org/w/index.php?title=Ibotenic_acid&oldid=1095441575}}</ref>
+[[Category:Amino acid]]
+[[Category:3-Hydroxyisoxazole]]
+[[Category:Hallucinogen]]
+==References==
+{{references}}
+<references />