DMT: Difference between revisions - PsychonautWiki Archive

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It is worth noting that many people report that smoked DMT is extremely clear-headed in its style and tends to produce less personal insight in comparison to orally active [[psychedelics]] such as [[ayahuasca]], [[LSD]] and [[psilocybin]] due to its short-acting nature.

An important detail that must be considered is that the majority of the following information about the effects that DMT can produce is extracted almost entirely from reports of smoked DMT. It's completely possible to induce a DMT trip with the co-ingestion of a MAOI but employing a different [[Routes of administration|ROA]] than oral (the latter ~~reffered~~ as [[ayahuasca]] or pharmahuasca), for example: [[rectal]], [[sublingual]] or [[intranasal]]. Such methods of consumption will allow the DMT to avoid passing through the liver and also ~~inhibe~~ the action of the MAO ~~enzimes~~, leading to "long DMT trips" that can provide a series of effects that are distinct to those of smoked DMT but that also differ slightly from classical ayahuasca experiences.

An important detail that must be considered is that the majority of the following information about the effects that DMT can produce is extracted almost entirely from reports of smoked DMT. It's completely possible to induce a DMT trip with the co-ingestion of a MAOI but employing a different [[Routes of administration|ROA]] than oral (the latter referred as [[ayahuasca]] or pharmahuasca), for example: [[rectal]], [[sublingual]] or [[intranasal]]. Such methods of consumption will allow the DMT to avoid passing through the liver and also inhibit the action of the MAO enzymes, leading to "long DMT trips" that can provide a series of effects that are distinct to those of smoked DMT but that also differ slightly from classical ayahuasca experiences.

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*'''[[Effect::Increased heart rate]]'''<ref name="strassman" />

*'''[[Effect::Increased blood pressure]]'''<ref name="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773875/" />

*'''[[Effect::Neurogenesis]]'''<ref name="pmid=32989216" />

*'''[[Effect::Neurogenesis]]'''<ref name="pmid=32989216" /> and '''[[Effect::Neuroplasticity]]'''<ref name="pmid=29898390" /> - Recent studies have shown that psychedelics, when done in a therapeutic setting and following harm reduction practices, can improve brain health by promoting neuron production and increasing plasticity.

*'''[[Effect::Pupil dilation]]'''<ref name="strassman" />

*'''[[Effect::Physical autonomy]]'''

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*'''[[Effect::Cognitive euphoria]]''' - When applied a "long trip" method, DMT can induce this effect with one of the highest consistencies among psychedelics, being sometimes described as "pure bliss or ecstasy". It's commonly reported that, when the peak starts transitioning into the come down of the experience, feelings of peace, fulfillment and appreciation will become central to the experience. Sometimes and depending on the set and setting, this effect can be accompanied by an [[existential self-realization]] and/or feelings of [[unity and interconnectedness]], which occasionally can lead to the user to a trascendental moment, even if the peak itself of the whole experience has already passed.

*'''[[Effect::Increased music appreciation]]''' - When DMT is smoked or vaporized, this effect typically occurs only at sub-breakthrough doses, and many people prefer to have their DMT experiences in complete silence to prevent a muddled or overwhelming experience. On the other side, when a MAOI is added and DMT is administred rectally, sublingually or intranasally, this effect can become as prominent as with [[LSD]] or [[psilocybin]] and sometimes will be central to the experience, especially during the come down.

*'''[[Effect::Memory formation enhancement]]''' - While many users experience amnesia during the peak of the experience, one can recall certain events of the trip with an increased facility, in comparison to the great majority of other drugs or everyday life. This effect can persist during the following hours or days after the experience.

*'''[[Effect::Memory suppression]]'''

**'''[[Effect::Ego death]]'''

@@ Line 80: / Line 80: @@
 It is worth noting that many people report that smoked DMT is extremely clear-headed in its style and tends to produce less personal insight in comparison to orally active [[psychedelics]] such as [[ayahuasca]], [[LSD]] and [[psilocybin]] due to its short-acting nature.
-An important detail that must be considered is that the majority of the following information about the effects that DMT can produce is extracted almost entirely from reports of smoked DMT. It's completely possible to induce a DMT trip with the co-ingestion of a MAOI but employing a different [[Routes of administration|ROA]] than oral (the latter reffered as [[ayahuasca]] or pharmahuasca), for example: [[rectal]], [[sublingual]] or [[intranasal]]. Such methods of consumption will allow the DMT to avoid passing through the liver and also inhibe the action of the MAO enzimes, leading to "long DMT trips" that can provide a series of effects that are distinct to those of smoked DMT but that also differ slightly from classical ayahuasca experiences.
+An important detail that must be considered is that the majority of the following information about the effects that DMT can produce is extracted almost entirely from reports of smoked DMT. It's completely possible to induce a DMT trip with the co-ingestion of a MAOI but employing a different [[Routes of administration|ROA]] than oral (the latter referred as [[ayahuasca]] or pharmahuasca), for example: [[rectal]], [[sublingual]] or [[intranasal]]. Such methods of consumption will allow the DMT to avoid passing through the liver and also inhibit the action of the MAO enzymes, leading to "long DMT trips" that can provide a series of effects that are distinct to those of smoked DMT but that also differ slightly from classical ayahuasca experiences.
 {{Preamble/SubjectiveEffects}}
@@ Line 91: / Line 91: @@
 *'''[[Effect::Increased heart rate]]'''<ref name="strassman" />
 *'''[[Effect::Increased blood pressure]]'''<ref name="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773875/" />
-*'''[[Effect::Neurogenesis]]'''<ref name="pmid=32989216" />
+*'''[[Effect::Neurogenesis]]'''<ref name="pmid=32989216" /> and '''[[Effect::Neuroplasticity]]'''<ref name="pmid=29898390" /> - Recent studies have shown that psychedelics, when done in a therapeutic setting and following harm reduction practices, can improve brain health by promoting neuron production and increasing plasticity.
 *'''[[Effect::Pupil dilation]]'''<ref name="strassman" />
 *'''[[Effect::Physical autonomy]]'''
@@ Line 167: / Line 167: @@
 *'''[[Effect::Cognitive euphoria]]''' - When applied a "long trip" method, DMT can induce this effect with one of the highest consistencies among psychedelics, being sometimes described as "pure bliss or ecstasy". It's commonly reported that, when the peak starts transitioning into the come down of the experience, feelings of peace, fulfillment and appreciation will become central to the experience. Sometimes and depending on the set and setting, this effect can be accompanied by an [[existential self-realization]] and/or feelings of [[unity and interconnectedness]], which occasionally can lead to the user to a trascendental moment, even if the peak itself of the whole experience has already passed.
 *'''[[Effect::Increased music appreciation]]''' - When DMT is smoked or vaporized, this effect typically occurs only at sub-breakthrough doses, and many people prefer to have their DMT experiences in complete silence to prevent a muddled or overwhelming experience. On the other side, when a MAOI is added and DMT is administred rectally, sublingually or intranasally, this effect can become as prominent as with [[LSD]] or [[psilocybin]] and sometimes will be central to the experience, especially during the come down.
+*'''[[Effect::Memory formation enhancement]]''' - While many users experience amnesia during the peak of the experience, one can recall certain events of the trip with an increased facility, in comparison to the great majority of other drugs or everyday life. This effect can persist during the following hours or days after the experience.
 *'''[[Effect::Memory suppression]]'''
 **'''[[Effect::Ego death]]'''