This is an unofficial archive of PsychonautWiki as of 2025-08-08T03:33:20Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
MAOI: Difference between revisions
>Cristobaldelicia m →Selective MAO-A inhibitors: changed "is" to "are" warning was grammatically incorrect |
>David Hedlund See also RIMA#Naturally occurring sources |
||
| (18 intermediate revisions by 2 users not shown) | |||
| Line 20: | Line 20: | ||
===Before MAOI consumption=== | ===Before MAOI consumption=== | ||
*Substances with slow elimination | *Substances with slow elimination | ||
**[[Methamphetamine]]: Because of its slow elimination, low concentrations of Methamphetamine can be detected in urine for up to 7 days after a single oral dose of 30 mg (Valentine et al., 1995) or up to 60 h after a single 15-mg smoked or intravenous dose (Cook et al., 1993).<ref>{{cite journal | vauthors=((Li, L.)), ((Galloway, G. P.)), ((Verotta, D.)), ((Everhart, E. T.)), ((Baggott, M. J.)), ((Coyle, J. R.)), ((Lopez, J. C.)), ((Mendelson, J.)) | journal=The Journal of Pharmacology and Experimental Therapeutics | title=A Method to Quantify Illicit Intake of Drugs from Urine: Methamphetamine | volume=338 | issue=1 | pages=31–36 | date= July 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126645/ | issn=0022-3565 | doi=10.1124/jpet.111.179176}}</ref> A chronic meth user might still test positive seven to 10 days after consuming the drug. | **[[Methamphetamine]]: Because of its slow elimination, low concentrations of Methamphetamine can be detected in urine for up to 7 days after a single oral dose of 30 mg (Valentine et al., 1995) or up to 60 h after a single 15-mg smoked or intravenous dose (Cook et al., 1993).<ref>{{cite journal | vauthors=((Li, L.)), ((Galloway, G. P.)), ((Verotta, D.)), ((Everhart, E. T.)), ((Baggott, M. J.)), ((Coyle, J. R.)), ((Lopez, J. C.)), ((Mendelson, J.)) | journal=The Journal of Pharmacology and Experimental Therapeutics | title=A Method to Quantify Illicit Intake of Drugs from Urine: Methamphetamine | volume=338 | issue=1 | pages=31–36 | date= July 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126645/ | issn=0022-3565 | doi=10.1124/jpet.111.179176}}</ref> A chronic meth user might still test positive seven to 10 days after consuming the drug. | ||
| Line 32: | Line 31: | ||
==Poly drug use== | ==Poly drug use== | ||
*[[Ayahuasca]]: The [[tryptamine]] [[DMT]] will break down without MAOIs when taken orally. | *[[Ayahuasca]]: The [[tryptamine]] [[DMT]] will break down without MAOIs when taken orally. | ||
| Line 41: | Line 39: | ||
===Nonselective MAOIs/RIMAs=== | ===Nonselective MAOIs/RIMAs=== | ||
See also [[RIMA#Naturally occurring sources|naturally occurring RIMA sources]]. | |||
*Naturally occurring sources | *Naturally occurring sources | ||
| Line 148: | Line 147: | ||
|Quercetin | |Quercetin | ||
|MAO-A | |MAO-A | ||
|- | |- | ||
|[[Peganum_harmala#Chemistry|Syrian rue (''Peganum harmala'')]] | |[[Peganum_harmala#Chemistry|Syrian rue (''Peganum harmala'')]] | ||
| Line 164: | Line 159: | ||
|[[Harmine]] | |[[Harmine]] | ||
|[[RIMA]] | |[[RIMA]] | ||
|- | |||
|''Rhodiola rosea'' (rose root) | |||
| | |||
|MAO-A, MAO-B<ref>{{cite journal | vauthors=((Diermen, D. van)), ((Marston, A.)), ((Bravo, J.)), ((Reist, M.)), ((Carrupt, P.-A.)), ((Hostettmann, K.)) | journal=Journal of Ethnopharmacology | title=Monoamine oxidase inhibition by Rhodiola rosea L. roots | volume=122 | issue=2 | pages=397–401 | date=18 March 2009 | issn=1872-7573 | doi=10.1016/j.jep.2009.01.007}}</ref> | |||
|- | |- | ||
|[[Nicotiana (botany)|Tobacco]] | |[[Nicotiana (botany)|Tobacco]] | ||
| Line 180: | Line 179: | ||
|Norharman<ref name="Tobacco" /> | |Norharman<ref name="Tobacco" /> | ||
|MAO-A, MAO-B<ref name="norharman" /> | |MAO-A, MAO-B<ref name="norharman" /> | ||
|- | |||
|Turmeric | |||
|Curcumin<ref>{{cite journal |last1=Khatri |first1=DK |last2=Juvekar |first2=AR |title=Kinetics of Inhibition of Monoamine Oxidase Using Curcumin and Ellagic Acid. |journal=Pharmacognosy magazine |date=May 2016 |volume=12 |issue=Suppl 2 |pages=S116-20 |doi=10.4103/0973-1296.182168 |pmid=27279695 |pmc=4883067}}</ref> | |||
|MAO-B | |||
|- | |- | ||
|} | |} | ||
| Line 222: | Line 225: | ||
===Selective MAO-B inhibitors=== | ===Selective MAO-B inhibitors=== | ||
*Naturally occurring sources | *Naturally occurring sources | ||
**Kava (''Piper methysticum''): Yangonin. Kava pyrones: The order of potency was desmethoxyyangonin > (+/-)-methysticin > yangonin > (+/-)-dihydromethysticin > (+/-)- dihydrokavain > (+/-)-kavain.<ref>{{cite journal | vauthors=((Uebelhack, R.)), ((Franke, L.)), ((Schewe, H. J.)) | journal=Pharmacopsychiatry | title=Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava) | volume=31 | issue=5 | pages=187–192 | date= September 1998 | issn=0176-3679 | doi=10.1055/s-2007-979325}}</ref> | **Kava (''Piper methysticum''): Yangonin. Kava pyrones: The order of potency was desmethoxyyangonin > (+/-)-methysticin > yangonin > (+/-)-dihydromethysticin > (+/-)- dihydrokavain > (+/-)-kavain.<ref>{{cite journal | vauthors=((Uebelhack, R.)), ((Franke, L.)), ((Schewe, H. J.)) | journal=Pharmacopsychiatry | title=Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava) | volume=31 | issue=5 | pages=187–192 | date= September 1998 | issn=0176-3679 | doi=10.1055/s-2007-979325}}</ref> | ||
| Line 232: | Line 234: | ||
===Unknown selectivity=== | ===Unknown selectivity=== | ||
*Psychedelics | *Psychedelics | ||
**[[5-MeO-AET]] | **[[5-MeO-AET]] | ||
| Line 290: | Line 291: | ||
====By chemicals==== | ====By chemicals==== | ||
*Amino acids, and amino acid metabolism metabolic intermediates | *Amino acids, and amino acid metabolism metabolic intermediates | ||
**Monoamine precursors | **Monoamine precursors | ||
| Line 361: | Line 361: | ||
====By pharmacotherapy==== | ====By pharmacotherapy==== | ||
*Antibiotics | *Antibiotics | ||
**Linezolid | **Linezolid | ||
| Line 409: | Line 408: | ||
===Essential vitamins and minerals=== | ===Essential vitamins and minerals=== | ||
*Vitamin B6: MAOIs may reduce blood levels of vitamin B6. Not studied on harmalas. But on tranylcypromine (a cyclopropane), and phenelzine (a hydrazine), two pharms with distinct chemical groups. | *Vitamin B6: MAOIs may reduce blood levels of vitamin B6. Not studied on harmalas. But on tranylcypromine (a cyclopropane), and phenelzine (a hydrazine), two pharms with distinct chemical groups. | ||
===Substances=== | ===Substances=== | ||
*[[Lysergamides]]: [[LSD]]. MAOIs seem to cause a greater reduction in the effects of LSD than SSRIs.<ref>{{Citation | title=Erowid LSD (Acid) Vault : LSD and Antidepressants, by Mike | url=https://erowid.org/chemicals/lsd/lsd_health3.shtml}}</ref> | *[[Lysergamides]]: [[LSD]]. MAOIs seem to cause a greater reduction in the effects of LSD than SSRIs.<ref>{{Citation | title=Erowid LSD (Acid) Vault : LSD and Antidepressants, by Mike | url=https://erowid.org/chemicals/lsd/lsd_health3.shtml}}</ref> | ||
===Research=== | ===Research=== | ||
*Naturally occurring sources | *Naturally occurring sources | ||
**''[[Mimosa tenuiflora (botany)|Mimosa tenuiflora]]'': As there have been no MAO inhibitors detected in M. tenuiflora, there is ongoing interest into how yurema exerts its visionary effects.<ref>{{Citation | title=Dimethyltryptamine - an overview, ScienceDirect Topics | url=https://www.sciencedirect.com/topics/neuroscience/dimethyltryptamine}}</ref> | **''[[Mimosa tenuiflora (botany)|Mimosa tenuiflora]]'': As there have been no MAO inhibitors detected in M. tenuiflora, there is ongoing interest into how yurema exerts its visionary effects.<ref>{{Citation | title=Dimethyltryptamine - an overview, ScienceDirect Topics | url=https://www.sciencedirect.com/topics/neuroscience/dimethyltryptamine}}</ref> | ||
==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[RIMA]] | *[[RIMA]] | ||
| Line 429: | Line 424: | ||
==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor Monoamine oxidase inhibitor (Wikipedia)] | *[https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor Monoamine oxidase inhibitor (Wikipedia)] | ||
*[https://en.wikipedia.org/wiki/Monoamine_oxidase_A Monoamine oxidase A (Wikipedia)] | *[https://en.wikipedia.org/wiki/Monoamine_oxidase_A Monoamine oxidase A (Wikipedia)] | ||
| Line 447: | Line 441: | ||
{{#set:Featured=true}} | {{#set:Featured=true}} | ||