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MAOI: Difference between revisions

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===Before MAOI consumption===
===Before MAOI consumption===
*Substances with slow elimination
*Substances with slow elimination
**[[Methamphetamine]]: Because of its slow elimination, low concentrations of Methamphetamine can be detected in urine for up to 7 days after a single oral dose of 30 mg (Valentine et al., 1995) or up to 60 h after a single 15-mg smoked or intravenous dose (Cook et al., 1993).<ref>{{cite journal | vauthors=((Li, L.)), ((Galloway, G. P.)), ((Verotta, D.)), ((Everhart, E. T.)), ((Baggott, M. J.)), ((Coyle, J. R.)), ((Lopez, J. C.)), ((Mendelson, J.)) | journal=The Journal of Pharmacology and Experimental Therapeutics | title=A Method to Quantify Illicit Intake of Drugs from Urine: Methamphetamine | volume=338 | issue=1 | pages=31–36 | date= July 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126645/ | issn=0022-3565 | doi=10.1124/jpet.111.179176}}</ref> A chronic meth user might still test positive seven to 10 days after consuming the drug.
**[[Methamphetamine]]: Because of its slow elimination, low concentrations of Methamphetamine can be detected in urine for up to 7 days after a single oral dose of 30 mg (Valentine et al., 1995) or up to 60 h after a single 15-mg smoked or intravenous dose (Cook et al., 1993).<ref>{{cite journal | vauthors=((Li, L.)), ((Galloway, G. P.)), ((Verotta, D.)), ((Everhart, E. T.)), ((Baggott, M. J.)), ((Coyle, J. R.)), ((Lopez, J. C.)), ((Mendelson, J.)) | journal=The Journal of Pharmacology and Experimental Therapeutics | title=A Method to Quantify Illicit Intake of Drugs from Urine: Methamphetamine | volume=338 | issue=1 | pages=31–36 | date= July 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126645/ | issn=0022-3565 | doi=10.1124/jpet.111.179176}}</ref> A chronic meth user might still test positive seven to 10 days after consuming the drug.
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==Poly drug use==
==Poly drug use==
*[[Ayahuasca]]: The [[tryptamine]] [[DMT]] will break down without MAOIs when taken orally.
*[[Ayahuasca]]: The [[tryptamine]] [[DMT]] will break down without MAOIs when taken orally.


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===Nonselective MAOIs/RIMAs===
===Nonselective MAOIs/RIMAs===
See also [[RIMA#Naturally occurring sources|naturally occurring RIMA sources]].


*Naturally occurring sources
*Naturally occurring sources
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|Quercetin
|Quercetin
|MAO-A
|MAO-A
|-
|''Rhodiola rosea'' (rose root)
|
|MAO-A, MAO-B<ref>{{cite journal | vauthors=((Diermen, D. van)), ((Marston, A.)), ((Bravo, J.)), ((Reist, M.)), ((Carrupt, P.-A.)), ((Hostettmann, K.)) | journal=Journal of Ethnopharmacology | title=Monoamine oxidase inhibition by Rhodiola rosea L. roots | volume=122 | issue=2 | pages=397–401 | date=18 March 2009 | issn=1872-7573 | doi=10.1016/j.jep.2009.01.007}}</ref>
|-
|-
|[[Peganum_harmala#Chemistry|Syrian rue (''Peganum harmala'')]]
|[[Peganum_harmala#Chemistry|Syrian rue (''Peganum harmala'')]]
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|[[Harmine]]
|[[Harmine]]
|[[RIMA]]
|[[RIMA]]
|-
|''Rhodiola rosea'' (rose root)
|
|MAO-A, MAO-B<ref>{{cite journal | vauthors=((Diermen, D. van)), ((Marston, A.)), ((Bravo, J.)), ((Reist, M.)), ((Carrupt, P.-A.)), ((Hostettmann, K.)) | journal=Journal of Ethnopharmacology | title=Monoamine oxidase inhibition by Rhodiola rosea L. roots | volume=122 | issue=2 | pages=397–401 | date=18 March 2009 | issn=1872-7573 | doi=10.1016/j.jep.2009.01.007}}</ref>
|-
|-
|[[Nicotiana (botany)|Tobacco]]
|[[Nicotiana (botany)|Tobacco]]
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|Norharman<ref name="Tobacco" />
|Norharman<ref name="Tobacco" />
|MAO-A, MAO-B<ref name="norharman" />
|MAO-A, MAO-B<ref name="norharman" />
|-
|Turmeric
|Curcumin<ref>{{cite journal |last1=Khatri |first1=DK |last2=Juvekar |first2=AR |title=Kinetics of Inhibition of Monoamine Oxidase Using Curcumin and Ellagic Acid. |journal=Pharmacognosy magazine |date=May 2016 |volume=12 |issue=Suppl 2 |pages=S116-20 |doi=10.4103/0973-1296.182168 |pmid=27279695 |pmc=4883067}}</ref>
|MAO-B
|-
|-
|}
|}
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===Selective MAO-B inhibitors===
===Selective MAO-B inhibitors===
*Naturally occurring sources
*Naturally occurring sources
**Kava (''Piper methysticum''): Yangonin. Kava pyrones: The order of potency was desmethoxyyangonin > (+/-)-methysticin > yangonin > (+/-)-dihydromethysticin > (+/-)- dihydrokavain > (+/-)-kavain.<ref>{{cite journal | vauthors=((Uebelhack, R.)), ((Franke, L.)), ((Schewe, H. J.)) | journal=Pharmacopsychiatry | title=Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava) | volume=31 | issue=5 | pages=187–192 | date= September 1998 | issn=0176-3679 | doi=10.1055/s-2007-979325}}</ref>
**Kava (''Piper methysticum''): Yangonin. Kava pyrones: The order of potency was desmethoxyyangonin > (+/-)-methysticin > yangonin > (+/-)-dihydromethysticin > (+/-)- dihydrokavain > (+/-)-kavain.<ref>{{cite journal | vauthors=((Uebelhack, R.)), ((Franke, L.)), ((Schewe, H. J.)) | journal=Pharmacopsychiatry | title=Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava) | volume=31 | issue=5 | pages=187–192 | date= September 1998 | issn=0176-3679 | doi=10.1055/s-2007-979325}}</ref>
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===Unknown selectivity===
===Unknown selectivity===
*Psychedelics
*Psychedelics
**[[5-MeO-AET]]
**[[5-MeO-AET]]
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====By chemicals====
====By chemicals====
*Amino acids, and amino acid metabolism metabolic intermediates
*Amino acids, and amino acid metabolism metabolic intermediates
**Monoamine precursors
**Monoamine precursors
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====By pharmacotherapy====
====By pharmacotherapy====
*Antibiotics
*Antibiotics
**Linezolid
**Linezolid
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===Essential vitamins and minerals===
===Essential vitamins and minerals===
*Vitamin B6: MAOIs may reduce blood levels of vitamin B6. Not studied on harmalas. But on tranylcypromine (a cyclopropane), and phenelzine (a hydrazine), two pharms with distinct chemical groups.
*Vitamin B6: MAOIs may reduce blood levels of vitamin B6. Not studied on harmalas. But on tranylcypromine (a cyclopropane), and phenelzine (a hydrazine), two pharms with distinct chemical groups.


===Substances===
===Substances===
*[[Lysergamides]]: [[LSD]]. MAOIs seem to cause a greater reduction in the effects of LSD than SSRIs.<ref>{{Citation | title=Erowid LSD (Acid) Vault : LSD and Antidepressants, by Mike | url=https://erowid.org/chemicals/lsd/lsd_health3.shtml}}</ref>
*[[Lysergamides]]: [[LSD]]. MAOIs seem to cause a greater reduction in the effects of LSD than SSRIs.<ref>{{Citation | title=Erowid LSD (Acid) Vault : LSD and Antidepressants, by Mike | url=https://erowid.org/chemicals/lsd/lsd_health3.shtml}}</ref>


===Research===
===Research===
*Naturally occurring sources
*Naturally occurring sources
**''[[Mimosa tenuiflora (botany)|Mimosa tenuiflora]]'': As there have been no MAO inhibitors detected in M. tenuiflora, there is ongoing interest into how yurema exerts its visionary effects.<ref>{{Citation | title=Dimethyltryptamine - an overview, ScienceDirect Topics | url=https://www.sciencedirect.com/topics/neuroscience/dimethyltryptamine}}</ref>
**''[[Mimosa tenuiflora (botany)|Mimosa tenuiflora]]'': As there have been no MAO inhibitors detected in M. tenuiflora, there is ongoing interest into how yurema exerts its visionary effects.<ref>{{Citation | title=Dimethyltryptamine - an overview, ScienceDirect Topics | url=https://www.sciencedirect.com/topics/neuroscience/dimethyltryptamine}}</ref>


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[RIMA]]
*[[RIMA]]
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==External links==
==External links==
*[https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor Monoamine oxidase inhibitor (Wikipedia)]
*[https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor Monoamine oxidase inhibitor (Wikipedia)]
*[https://en.wikipedia.org/wiki/Monoamine_oxidase_A Monoamine oxidase A (Wikipedia)]
*[https://en.wikipedia.org/wiki/Monoamine_oxidase_A Monoamine oxidase A (Wikipedia)]
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{{#set:Featured=true}}
{{#set:Featured=true}}
<references />
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