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Talk:Glaucine: Difference between revisions
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{{SummarySheet}} | {{SummarySheet}} | ||
Glaucine is a naturally occurring novel [[psychedelic]] substance of the [[aporphine]] class found in ''[[Glaucium Flavum]]''.<ref>https://link.springer.com/article/10.1023/B:PHAC.0000048907.58847.c6</ref> Glaucine has one stereocenter, therefore it has two stereoisomers, where (S)-Glaucine is a 5-HT<sub>2A</sub> [[agonist]] and (R)-Glaucine is a 5-HT<sub>2</sub> positive allosteric modulator.<ref name=":1">https://onlinelibrary.wiley.com/doi/10.1111/cbdd.13390</ref> Its psychedelic effects are believed to be produced by its interaction with [[serotonin]] [[Receptor|receptors]] like most psychedelics do, but also has clinically significant interactions at D1<ref>https://www.sciencedirect.com/science/article/abs/pii/S0968089605002312?via%3Dihub</ref> and α1<ref name=":2">https://pubmed.ncbi.nlm.nih.gov/30216681/</ref> receptors as an [[antagonist]], and inhibits MOA to a moderate degree.<ref>https://www.sciencedirect.com/science/article/abs/pii/S0021967319301104?via%3Dihub</ref> Glaucine has a close relative found in [[Blue Lotus]] (''Nymphaea nouchali)'' called [[apomorphine]]. It is both psychedelic as well as sedating, but the [[sedation]] is more similar to that of [[opioids]] than [[Psilocybin mushrooms|psilocybin]], a generally sedating psychedelic. It is most commonly consumed [[Routes of administration|orally]]. | Glaucine is a naturally occurring novel [[psychedelic]] substance of the [[aporphine]] class found in ''[[Glaucium Flavum]]''.<ref>https://link.springer.com/article/10.1023/B:PHAC.0000048907.58847.c6</ref> Glaucine has one stereocenter, therefore it has two stereoisomers, where (S)-Glaucine is a 5-HT<sub>2A</sub> [[agonist]] and (R)-Glaucine is a 5-HT<sub>2</sub> positive allosteric modulator.<ref name=":1">https://onlinelibrary.wiley.com/doi/10.1111/cbdd.13390</ref> Its psychedelic effects are believed to be produced by its interaction with [[serotonin]] [[Receptor|receptors]] like most psychedelics do, but also has clinically significant interactions at D1<ref>https://www.sciencedirect.com/science/article/abs/pii/S0968089605002312?via%3Dihub</ref> and α1<ref name=":2">https://pubmed.ncbi.nlm.nih.gov/30216681/</ref> receptors as an [[antagonist]], and inhibits MOA to a moderate degree.<ref>https://www.sciencedirect.com/science/article/abs/pii/S0021967319301104?via%3Dihub</ref> Glaucine has a close relative found in [[Blue Lotus]] (''Nymphaea nouchali)'' called [[apomorphine]]. It is both psychedelic as well as sedating, but the [[sedation]] is more similar to that of [[opioids]] than [[Psilocybin mushrooms|psilocybin]], a generally sedating psychedelic. It is most commonly consumed [[Routes of administration|orally]]. | ||
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*'''[[Effect::Muscle relaxation]]''' | *'''[[Effect::Muscle relaxation]]''' | ||
*'''[[Effect::Perception of bodily heaviness]]''' | *'''[[Effect::Perception of bodily heaviness]]''' | ||
*'''[[Effect:: | *'''[[Effect::Physical euphoria]]''' - It is usually felt as a warm encompassment of the body. | ||
*'''[[Effect::Pupil dilation]]''' - Serotonergic substances are known to cause pupil dilation. | *'''[[Effect::Pupil dilation]]''' - Serotonergic substances are known to cause pupil dilation. | ||
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====Enhancements==== | ====Enhancements==== | ||
*'''[[Effect::Pattern recognition | *'''[[Effect::Pattern recognition enhancement]]''' | ||
}} | }} | ||
}} | }} | ||
===Experience reports=== | ===Experience reports=== | ||
There are currently {{#ask:[[Category: | There are currently {{#ask:[[Category:Glaucine]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]]. Additional experience reports can be found here: | ||
*[https://www.erowid.org/experiences/subs/exp_Glaucine.shtml Erowid Experience Vaults: Glaucine] | *[https://www.erowid.org/experiences/subs/exp_Glaucine.shtml Erowid Experience Vaults: Glaucine] | ||
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===Dangerous interactions=== | ===Dangerous interactions=== | ||
{{DangerousInteractions}} | |||
{{DangerousInteractions/Intro}} | |||
*'''Lithium''': Lithium is commonly prescribed in the treatment of bipolar disorder; however, there is a large body of anecdotal evidence that suggests taking it with psychedelics can significantly increase the risk of [[psychosis]] and [[seizures]]. As a result, this combination should be '''strictly avoided.''' | *'''Lithium''': Lithium is commonly prescribed in the treatment of bipolar disorder; however, there is a large body of anecdotal evidence that suggests taking it with psychedelics can significantly increase the risk of [[psychosis]] and [[seizures]]. As a result, this combination should be '''strictly avoided.''' | ||
*'''[[Tramadol]]''': Tramadol is well documented to lower the seizure threshold in individuals and psychedelics also has the potential to induce seizures in susceptible individuals.<ref>https://www.sciencedirect.com/science/article/pii/S0376871622003234?via%3Dihub</ref> | *'''[[Tramadol]]''': Tramadol is well documented to lower the seizure threshold in individuals and psychedelics also has the potential to induce seizures in susceptible individuals.<ref>https://www.sciencedirect.com/science/article/pii/S0376871622003234?via%3Dihub</ref> | ||
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*'''[[Stimulants]]''': (e.g. [[Amphetamine|'''''amphetamine''''']], [[Project talk:Methcathinone|'''''methcathinone''''']]): Due to a moderate inhibition of MAO-B, stimulants in combination with glaucine will cause a massive spike in blood pressure leading to hypertensive crisis as well as prolonged and more intense effects of stimulants. This combination should be '''strictly avoided.''' | *'''[[Stimulants]]''': (e.g. [[Amphetamine|'''''amphetamine''''']], [[Project talk:Methcathinone|'''''methcathinone''''']]): Due to a moderate inhibition of MAO-B, stimulants in combination with glaucine will cause a massive spike in blood pressure leading to hypertensive crisis as well as prolonged and more intense effects of stimulants. This combination should be '''strictly avoided.''' | ||
*'''Tyramine''': Any food with a high level of tyramine should be avoided for two weeks after use. MAO-B inhibition can lead to a buildup of tyramine in the body, leading to a hypertensive crisis. | *'''Tyramine''': Any food with a high level of tyramine should be avoided for two weeks after use. MAO-B inhibition can lead to a buildup of tyramine in the body, leading to a hypertensive crisis. | ||
==Legal status== | ==Legal status== | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/Glaucine Glaucine (Wikipedia)] | |||
==References== | ==References== | ||