Butylone: Difference between revisions

>Unity
>Myriadis
m Added legal status in France
 
(146 intermediate revisions by 17 users not shown)
Line 1: Line 1:
{{proofread}}
{{headerpanel|}}
{{SummarySheet}}
{{SubstanceBox/Butylone}}
{{SubstanceBox/Butylone}}
{|
|-
|-
| ''[[Butylone/Summary|Summary sheet: Butylone]]''
|}
'''Butylone''' (also known as '''β-keto-''N''-methylbenzodioxolylbutanamine''', '''βk-MBDB''', or '''B1''') is a synthetic [[entactogen]] and [[psychoactive class::stimulant]] of the [[phenethylamine]] and [[chemical class::cathinone]] classes. Butylone is the β-keto analog of [[MDBD]] and the substituted methylenedioxy analogue of [[buphedrone]].


As a [[designer drug]], it along with [[ethylone]] and [[methylone]] is commonly sold on the street as a substitute or counterfeit for [[MDMA]] (all of which have collectively come to be referred to as "Molly") due to methylone's declining availability on the [[research chemical]]s market. However, in spite of behavioral and pharmacological similarities between butylone and MDMA, the observed subjective effects of both drugs are not completely identical. <ref name="urlCathinone | Ask Dr. Shulgin Online">{{cite web | url = http://www.cognitiveliberty.org/shulgin/adsarchive/cathinone.htm | title = Cathinone &#124; Ask Dr. Shulgin Online }}</ref>
'''Butylone''' (also known as '''β-keto-''N''-methylbenzodioxolylbutanamine''', '''βk-MBDB''', or '''B1''') is a synthetic [[entactogen]] and [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] class. It is the β-keto analog of [[MBDB]] and the substituted methylenedioxy analogue of [[buphedrone]].


Butylone has only a short history of human use and is reported to be less potent than its relatives [[methylone]] and [[ethylone]] as well as possessing more classic [[stimulant]] as opposed to entactogenic effects.
As a [[designer drug]], it is commonly sold on the street along with [[ethylone]] as a substitute or counterfeit for [[MDMA]] and [[methylone]] (all of which have collectively come to be referred to as "Molly") due to methylone's declining availability on the [[research chemical]] market. However, in spite of behavioral and pharmacological similarities between butylone and MDMA, the observed subjective effects of both substances are not completely identical.<ref name="urlCathinone | Ask Dr. Shulgin Online">{{cite web | url = http://www.cognitiveliberty.org/shulgin/adsarchive/cathinone.htm | title = Cathinone &#124; Ask Dr. Shulgin Online }}</ref>
 
Subjective effects include [[stimulation]], [[thought acceleration]], [[motivation enhancement]], [[increased libido]], [[appetite suppression]], and [[euphoria]], Butylone is reported to be less potent than its relatives [[methylone]] and [[ethylone]] as well as possessing more classic [[stimulant]] as opposed to entactogenic effects.
 
Butylone has a very short history of human use and very little data exists about its pharmacological properties, metabolism, and toxicity. It is highly advised to use [[harm reduction practices]] if using this substance.


==Chemistry==
==Chemistry==
Butylone, or '''β-keto-''N''-methylbenzodioxolylbutanamine''', is a synthetic molecule of the [[cathinone]] family.  Cathinones are structurally similar to amphetamines in that they contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional ethyl substitution at R<sub>α</sub>. Cathinones such as butylone are alpha-methylated phenethylamines (i.e. [[amphetamine]]s) but differ from them with the addition of a ketone functional group (a carbonyl group at R<sub>β</sub>). Butylone contains a methyl substitution at R<sub>N</sub>, a substitution which is shared with [[MDEA]], [[ethylone]], [[4-MEC]], and certain other stimulants and entactogens. Additionally, butylone contains substitutions at R<sub>3</sub> and R<sub>4</sub> of the phenyl ring with oxygen groups. These oxygen groups are incorporated into a methylenedioxy ring through a methylene chain. Butylone shares this methylenedioxy ring with [[MDA]], [[MDAI]] and [[MDMA]].
Butylone, or '''β-keto-''N''-methylbenzodioxolylbutanamine''', is a synthetic molecule of the [[Substituted cathinone|cathinone]] family.  Cathinones are structurally similar to amphetamines in that they contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional ethyl substitution at R<sub>α</sub>. Cathinones such as butylone are alpha-methylated phenethylamines (i.e. [[amphetamine]]s) but differ from them with the addition of a ketone functional group (a carbonyl group at R<sub>β</sub>). Butylone contains a methyl substitution at R<sub>N</sub>, a substitution which is shared with [[MDEA]], [[ethylone]], [[4-MEC]], and certain other stimulants and entactogens. Additionally, butylone contains substitutions at R<sub>3</sub> and R<sub>4</sub> of the phenyl ring with oxygen groups. These oxygen groups are incorporated into a methylenedioxy ring through a methylene chain. Butylone shares this methylenedioxy ring with [[MDA]], [[MDAI]] and [[MDMA]].


==Pharmacology==
==Pharmacology==
Butylone acts as a mixed [[reuptake inhibitor]]/[[releasing agent]] of [[serotonin]], [[norepinephrine]], and [[dopamine]].<ref>Inhibition of plasma membrane monoamine transporters by beta-ketoamphetamines (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10528135</ref><ref>The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0014299906013811</ref> These are the [[neurotransmitters]] in charge of pleasure, reward, motivation and focus. This is done by inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse, essentially allowing them to accumulate and be reused, causing physically stimulating and euphoric effects.  
Butylone acts as a mixed [[reuptake inhibitor]]/[[releasing agent]] of [[serotonin]], [[norepinephrine]], and [[dopamine]].<ref>{{cite journal | vauthors=((Cozzi, N. V.)), ((Sievert, M. K.)), ((Shulgin, A. T.)), ((Jacob, P.)), ((Ruoho, A. E.)) | journal=European Journal of Pharmacology | title=Inhibition of plasma membrane monoamine transporters by beta-ketoamphetamines | volume=381 | issue=1 | pages=63–69 | date=17 September 1999 | issn=0014-2999 | doi=10.1016/s0014-2999(99)00538-5}}</ref><ref name="Nagai2007">{{cite journal | vauthors=((Nagai, F.)), ((Nonaka, R.)), ((Satoh Hisashi Kamimura, K.)) | journal=European Journal of Pharmacology | title=The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain | volume=559 | issue=2 | pages=132–137 | date=22 March 2007 | url=https://www.sciencedirect.com/science/article/pii/S0014299906013811 | issn=0014-2999 | doi=10.1016/j.ejphar.2006.11.075}}</ref> These are the [[neurotransmitters]] in charge of pleasure, reward, motivation and focus. This is done by inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse, essentially allowing them to accumulate and be reused, causing physically stimulating and euphoric effects.  


In comparison to [[methylone]], it has approximately over 4x lower affinity for the norepinephrine transporter, while its affinity for the serotonin and dopamine transporters is similar.<ref>"Pharmacological characterization of designer cathinones in vitro" | http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02145.x/pdf</ref><ref>The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0014299906013811</ref> The results of these differences in pharmacology relative to [[MDMA]] is that butylone, like its close analog [[ethylone]] is less potent in terms of dose, has more balanced [[catecholaminergic]] effects relative to serotonergic, and behaves more like a [[reuptake inhibitor]] like [[methylphenidate]] than a releaser like [[amphetamine]]; however, butylone still has relatively robust releasing capabilities.<ref>"Pharmacological characterization of designer cathinones in vitro" | http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02145.x/pdf</ref>
In comparison to [[methylone]], it has approximately over 4x lower affinity for the norepinephrine transporter, while its affinity for the serotonin and dopamine transporters is similar.<ref name="Simmler2013">{{cite journal | vauthors=((Simmler, L.)), ((Buser, T.)), ((Donzelli, M.)), ((Schramm, Y.)), ((Dieu, L.-H.)), ((Huwyler, J.)), ((Chaboz, S.)), ((Hoener, M.)), ((Liechti, M.)) | journal=British Journal of Pharmacology | title=Pharmacological characterization of designer cathinones in vitro: Pharmacology of cathinones | volume=168 | issue=2 | pages=458–470 | date= January 2013 | url=https://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02145.x | issn=00071188 | doi=10.1111/j.1476-5381.2012.02145.x}}</ref><ref name="Nagai2007"/> The results of these differences in pharmacology relative to [[MDMA]] is that butylone, like its close analog [[ethylone]] is less potent in terms of dose, has more balanced [[catecholaminergic]] effects relative to serotonergic, and behaves more like a [[reuptake inhibitor]] like [[methylphenidate]] than a releaser like [[amphetamine]]; however, butylone still has relatively robust releasing capabilities.<ref name="Simmler2013"/>


==Subjective effects==
==Subjective effects==
The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
{{Preamble/SubjectiveEffects}}
===Physical effects===
{{effects/base
*'''[[Effect::Spontaneous tactile sensations]]''' - The "body high" of butylone can be described as a moderate to extreme euphoric tingling sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher doses. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
 
*'''[[Effect::Stimulation]]''' - In terms of its effects on the user's physical energy levels, butylone is commonly considered to be extremely stimulating and energetic. This encourages activities such as running, climbing and dancing in a way that makes butylone a popular choice for musical events such as festivals and raves. The particular style of stimulation which butylone presents can be described as forced. This means that at higher doses, it becomes difficult or impossible to keep still as jaw clenching, involuntarily bodily shakes, and vibrations become present, resulting in an extreme unsteadiness of the hands and a general lack of motor control.  
|{{effects/physical|
*'''[[Effect::Vibrating vision]]''' - At high doses, a person's eyeballs may begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus. This is a condition known as [http://en.wikipedia.org/wiki/Nystagmus nystagmus].
*'''[[Effect::Stimulation]]''' - In terms of its effects on the user's physical energy levels, butylone is commonly considered to be highly stimulating and energetic. This encourages activities such as running, climbing and dancing in a way that makes butylone a popular choice for musical events such as festivals and raves. The particular style of stimulation which butylone presents can be described as forced. This means that at higher doses, it becomes difficult or impossible to keep still as jaw clenching, involuntarily bodily shakes, and vibrations become present, resulting in an extreme unsteadiness of the hands and a general lack of motor control.
*'''[[Effect::Dehydration]]''' - Feelings of dry mouth and dehydration are a universal experience with butylone; this effect is a product of an increased heart rate and an extreme motivation to engage in strenuous physical activities. While it is important to avoid becoming dehydrated (especially when out dancing in a hot environment) there have been a number of users suffering from [[water intoxication]] through over-drinking, so it is advised that users simply sip at water and never over-drink.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of butylone can be described as a strong euphoric tingling sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher doses. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
*'''[[Effect::Difficulty urinating]]''' - Higher doses of butylone result in an overall difficulty when it comes to urination. This is an effect that is completely temporary and harmless. It is due to butylone’s promotion of the release of anti-diuretic hormone (ADH). ADH is responsible for regulating urination. This effect can be lessened by simply relaxing, but can be significantly relieved by placing a hot flannel over the genitals to warm them up and encourage blood flow.
*'''[[Effect::Vibrating vision]]''' - At high doses, a person's eyeballs may begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus. This is a condition known as [http://en.wikipedia.org/wiki/Nystagmus nystagmus].
*'''[[Effect::Dehydration]]''' - Feelings of dry mouth and dehydration are a universal experience with butylone; this effect is a product of an increased heart rate and an extreme motivation to engage in strenuous physical activities. While it is important to avoid becoming dehydrated (especially when out dancing in a hot environment) there have been some users suffering from [[water intoxication]] through over-drinking, so it is advised that users simply sip at water and never over-drink.
*'''[[Effect::Difficulty urinating]]''' - Higher doses of butylone result in an overall difficulty when it comes to urination. This is an effect that is entirely temporary and harmless. It is due to butylone’s promotion of the release of anti-diuretic hormone (ADH). ADH is responsible for regulating urination. This effect can be lessened by simply relaxing, but can be significantly relieved by placing a hot flannel over the genitals to warm them up and encourage blood flow.
*'''[[Effect::Temperature regulation suppression]]'''
*'''[[Effect::Temperature regulation suppression]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Tactile enhancement]]'''
Line 34: Line 35:
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Teeth grinding]]''' - This component can be considered to be less intense when compared with that of [[MDMA]].
*'''[[Effect::Teeth grinding]]''' - This component can be considered to be less intense when compared with that of [[MDMA]].
*'''[[Effect::Increased music appreciation]]'''


===Cognitive effects===
}}
The cognitive effects of butylone can be broken down into several components which progressively intensify proportional to dosage. The general head space of butylone is described by many as one of extreme mental stimulation, light feelings of love or empathy and moderate euphoria. It contains a large number of typical [[Psychedelics|psychedelic]], [[Entactogens|entactogenic]] and [[Stimulants|stimulant]] cognitive effects.  
|{{effects/cognitive|
The cognitive effects of butylone can be broken down into several components which progressively intensify proportional to dosage. The general headspace of butylone is described by many as one of extreme mental stimulation, light feelings of love or empathy and moderate euphoria. It contains a large number of typical [[Psychedelics|psychedelic]], [[Entactogens|entactogenic]] and [[Stimulants|stimulant]] cognitive effects.  


The most prominent of these cognitive effects generally include:
The most prominent of these cognitive effects include:


*'''[[Effect::Cognitive euphoria]]''' - Strong emotional euphoria and feelings of happiness are present within butylone and are likely a direct result of serotonin and dopamine release. In comparison to MDMA, it is closer in effects to that of the euphoria felt within [[amphetamine]] and [[mephedrone]].
*'''[[Effect::Cognitive euphoria]]''' - Strong emotional euphoria and feelings of happiness are present within butylone and are likely a direct result of serotonin and dopamine release. In comparison to MDMA, it is closer in effects to that of the euphoria felt within [[amphetamine]] and [[mephedrone]].
Line 50: Line 51:
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased music appreciation]]'''


===After effects===
}}
{{effects/aftereffects|
The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include:
The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include:
*'''[[Effect::Anxiety]]'''
*'''[[Effect::Anxiety]]'''
Line 59: Line 61:
*'''[[Effect::Thought deceleration]]'''  
*'''[[Effect::Thought deceleration]]'''  
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Wakefulness]]'''
}}
}}
===Experience reports===
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
* [https://www.erowid.org/experiences/subs/exp_bkMBDB.shtml Erowid Experience Vaults: Butylone]


==Toxicity and harm potential==
==Toxicity and harm potential==
{{Main|Research chemicals#Toxicity and harm potential}}
{{Further|Research chemicals#Toxicity and harm potential}}
The toxicity and long-term health effects of recreational butylone use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because butylone has very little history of human usage. Anecdotal evidence from people who have tried butylone within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).  
The toxicity and long-term health effects of recreational butylone use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because butylone has very little history of human usage. Anecdotal evidence from people who have tried butylone within the community suggests that there do not seem to be strong adverse effects attributed to using this substance at low to moderate doses and sparingly.  


It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
===Tolerance and addiction potential===
===Tolerance and addiction potential===
As with other [[stimulant]]s, the chronic use of butylone can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
As with other [[stimulant]]s, the chronic use of butylone can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
Line 71: Line 79:
===Psychosis===
===Psychosis===
{{Main|Stimulant psychosis}}
{{Main|Stimulant psychosis}}
Abuse of compounds within the stimulant class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., [[Paranoia|paranoia]], [[External hallucinations|hallucinations]], or [[Delusions|delusions]]).<ref>Treatment for amphetamine psychosis | [http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003026.pub3/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+Saturday%2C+15+March+from+10%3A00-12%3A00+GMT+%2806%3A00-08%3A00+EDT%29+for+essential+maintenance]</ref> A review on treatment for amphetamine, [[amphetamine|dextroamphetamine]], and [[methamphetamine]] abuse-induced psychosis states that about 5–15% of users fail to recover completely.<ref>Treatment for amphetamine psychosis | [http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003026.pub3/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+Saturday%2C+15+March+from+10%3A00-12%3A00+GMT+%2806%3A00-08%3A00+EDT%29+for+essential+maintenance]</ref><ref>Hofmann FG (1983). A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects (2nd ed.). New York: Oxford University Press. p. 329. ISBN 9780195030570.</ref> The same review asserts that, based upon at least one trial, [[antipsychotic]] medications effectively resolve the symptoms of acute amphetamine psychosis.<ref>Treatment for amphetamine psychosis | [http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003026.pub3/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+Saturday%2C+15+March+from+10%3A00-12%3A00+GMT+%2806%3A00-08%3A00+EDT%29+for+essential+maintenance]</ref> Psychosis very rarely arises from therapeutic use.<ref>Stimulant Misuse: Strategies to Manage a Growing Problem | http://www.acha.org/prof_dev/ADHD_docs/ADHD_PDprogram_Article2.pdf</ref><ref>http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021303s026lbl.pdf</ref>
Abuse of compounds within the stimulant class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., [[Paranoia|paranoia]], [[External hallucinations|hallucinations]], or [[Delusions|delusions]]).<ref name="Shoptaw2009">{{cite journal | vauthors=((Shoptaw, S. J.)), ((Kao, U.)), ((Ling, W.)) | veditors=((Cochrane Drugs and Alcohol Group)) | journal=Cochrane Database of Systematic Reviews | title=Treatment for amphetamine psychosis | date=21 January 2009 | url=https://doi.wiley.com/10.1002/14651858.CD003026.pub3 | issn=14651858 | doi=10.1002/14651858.CD003026.pub3}}</ref> A review on treatment for amphetamine, [[amphetamine|dextroamphetamine]], and [[methamphetamine]] abuse-induced psychosis states that about 5–15% of users fail to recover completely.<ref name="Shoptaw2009"/><ref>{{cite book | vauthors=((Hofmann, F. G.)) | date= 1983 | title=A handbook on drug and alcohol abuse: the biomedical aspects | publisher=Oxford University Press | edition=2nd ed | isbn=9780195030563}}</ref> The same review asserts that, based upon at least one trial, [[antipsychotic]] medications effectively resolve the symptoms of acute amphetamine psychosis.<ref name="Shoptaw2009"/> Psychosis very rarely arises from therapeutic use.<ref>http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021303s026lbl.pdf</ref>
===Dangerous interactions===
===Dangerous interactions===
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
{{DangerousInteractions/Intro}}
*'''[[Stimulants]]''' - Butylone can be potentially dangerous in combination with other [[stimulant]]s as it can [[increased heart rate|increase one's heart rate]] and [[increased blood pressure|blood pressure]] to dangerous levels.
{{DangerousInteractions/Stimulants}}
{{DangerousInteractions/Stimulants}}
*'''[[Cocaine]]''' - This combination may increase strain on the heart.
 
====[[Serotonin syndrome]] risk====
====[[Serotonin syndrome]] risk====
{{DangerousInteractions/SerotoninSyndrome}}
{{DangerousInteractions/SerotoninSyndrome}}


==Legal issues==
==Legal status==
*'''United Kingdom''' - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
{{legalStub}}
*'''United States''' - Butylone is unscheduled in the United States. However it could be considered an analog of [[methylone]] or [[MDMA]], thus making it illegal under the scope of the Federal Analog Act.
*'''Austria''': Butylone is illegal to possess, produce and sell under the NPSG (''New Psychoactive Substances Act'').{{citation needed}}
*'''China''' - As of October 2015 butylone is a controlled substance in China.<ref>{{cite web | url=http://www.sfda.gov.cn/WS01/CL0056/130753.html | title=关于印发《非药用类麻醉药品和精神药品列管办法》的通知 | publisher=China Food and Drug Administration | date=27 September 2015 | language=Chinese | accessdate=1 October 2015}}</ref>
*'''Brazil''': As of September 7, 2018, all cathinone analogues are controlled substances considered illegal to possess, use and distribute. This was made possible due to a blanket ban law appended to Portaria SVS/MS nº 344.<ref>New blanket ban on synthetic illegal drugs is approved (Portuguese) | http://portal.anvisa.gov.br/noticias/-/asset_publisher/FXrpx9qY7FbU/content/combate-a-drogas-ilicitas-sinteticas-fica-mais-facil/219201/pop_up?_101_INSTANCE_FXrpx9qY7FbU_viewMode=print&_101_INSTANCE_FXrpx9qY7FbU_languageId=pt_BR</ref>
*'''Canada''': Butylone is controlled as a Schedule I substance.{{citation needed}}
*'''China''': As of October 2015 butylone is a controlled substance in China.<ref>{{cite web | url=http://www.sfda.gov.cn/WS01/CL0056/130753.html | title=关于印发《非药用类麻醉药品和精神药品列管办法》的通知 | publisher=China Food and Drug Administration | date=27 September 2015 | language=Chinese | accessdate=1 October 2015}}</ref>
*'''Finland''': Butylone is a controlled substance.{{citation needed}}
*'''France''': Butylone is scheduled as a "stupéfiant", i.e. a recognized drug of abuse. It is illegal to possess, buy, sell or manufacture.<ref>{{Citation | title=Arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants  | url=https://www.legifrance.gouv.fr/loda/id/JORFTEXT000000533085/2020-11-20/}}</ref>
*'''Germany''': Butylone is controlled under Anlage II BtMG (''Narcotics Act, Schedule II'')<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/anlage_ii.html|title=Anlage II BtMG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 25, 2019|language=de}}</ref> as of July 26, 2012.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?start=%2F%2F*%5B%40attr_id%3D%27bgbl112s1639.pdf%27%5D|title=Sechsundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften|publisher=Bundesanzeiger Verlag|access-date=December 25, 2019|language=de}}</ref> It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/__29.html|title=§ 29 BtMG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 25, 2019|language=de}}</ref>
*'''Israel''': Butylone is a controlled substance.{{citation needed}}
*'''Japan''': Butylone is a controlled substance.{{citation needed}}
*'''Norway''': Butylone is a controlled substance.{{citation needed}}
*'''Poland''': Butylone is a controlled substance.{{citation needed}}
*'''Sweden''': Butylone is a Schedule I controlled substance as of February 1, 2010.<ref>{{cite web|url=https://lakemedelsverket.se/upload/lvfs/LVFS_2010-1.pdf | title=Föreskrifter om ändring i Läkemedelsverkets föreskrifter (LVFS 1997:12) om förteckningar över narkotika| publisher=Läkemedelsverkets författningssamling|language=Swedish|access-date=December 25, 2019}}</ref>
*'''Switzerland''': Butylone is a controlled substance specifically named under Verzeichnis D.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': Butylone is a Class B drug in the United Kingdom as a result of the cathinone catch-all clause.<ref>{{Citation | title=The Misuse of Drugs Act 1971 (Amendment) Order 2010 | url=https://www.legislation.gov.uk/uksi/2010/1207/made}}</ref>
*'''United States''': Butylone is unscheduled in the United States. However it could be considered an analog of [[methylone]] or [[MDMA]], thus making it illegal under the scope of the Federal Analog Act.{{citation needed}}


==See also==
==See also==
Line 89: Line 109:
*[[Entactogens]]
*[[Entactogens]]
*[[Stimulants]]
*[[Stimulants]]
*[[Amphetamines]]
*[[Amphetamine]]
*[[Cathinones]]
*[[Substituted cathinone]]
*[[Mephedrone]]
*[[MDMA]]
*[[Methylone]]
*[[Methylone]]
*[[Ethylone]]
*[[Ethylone]]


==External links==
==External links==
*[http://en.wikipedia.org/wiki/butylone Butylone (Wikipedia)]
*[https://en.wikipedia.org/wiki/butylone Butylone (Wikipedia)]
*[https://www.erowid.org/chemicals/butylone/ Butylone (Erowid)]
*[https://erowid.org/chemicals/butylone/ Butylone (Erowid Vault)]
*[https://www.erowid.org/experiences/subs/exp_Butylone.shtml Butylone experiences (Erowid)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=2042 Butylone (Isomer Design)]
*[http://drugs.tripsit.me/butylone Butylone (TripSit)]
*[http://www.bluelight.org/vb/threads/310038-The-Big-amp-Dandy-bk-MBDB-(Butylone)-Thread BK-MBDB (Bluelight)]
*[http://www.bluelight.org/vb/threads/310038-The-Big-amp-Dandy-bk-MBDB-(Butylone)-Thread BK-MBDB (Bluelight)]


==References==
==References==
<references/>
<references />
 
[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Amphetamine]]
[[Category:Stimulant]]
[[Category:Stimulant]]
[[Category:Entactogen]]
[[Category:MDxx]]
[[Category:Cathinone]]
[[Category:Cathinone]]
[[Category:Substance]]
[[Category:Research chemical]]
{{#set:Featured=false}}
 
{{#set:Featured=true}}