Talk:Mebroqualone: Difference between revisions

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'''Mebroqualone''' ~~(brand name '''Quaalude''' in the US and '''Mandrax''' in the UK)~~ is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]]. The sedative–hypnotic activity of Mebroqualone was first noted by researchers in the 1950s and in 1962 Mebroqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational drug throughout the world. The drug was popular in the 1970s with hippies and in the disco club scene.

'''Mebroqualone''' is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]].

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The sedative–hypnotic activity of Mebroqualone was first noted by researchers in the 1950s and in 1962 Mebroqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational drug throughout the world. The drug was popular in the 1970s with hippies and in the disco club scene.{{citation needed}} --> <!-- where is a source for all this? i get a feeling this was copied from methaqualone

-->

Not much is known about this substance besides it being significantly more potent than [[methaqualone]] and shorter-lasting. It should be noted that methaqualone and its derivatives are prone to dangerous side effects such as respiratory depression and convulsions.{{citation needed}} It is therefore highly suggested to use [[harm reduction]] practices if using this substance.

==Chemistry==

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==Pharmacology==

Despite prior speculation, a 2015 study demonstrates that Mebroqualone exhibits distinct functional properties at the [[GABA]] [[receptor]] sites compared with other allosteric modulators, and it mediates these through a different mechanism than the [[barbiturates]] and [[benzodiazepines]] that it historically has been lumped together with.<ref name="ncbi qualuude study">A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Mebroqualone (Quaalude) (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/26056160</ref>

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*'''[[Effect::Constipation]]'''

*'''[[Effect::Changes in felt gravity]]'''

*'''[[Effect::Seizures]]'''{{citation needed}} - Methaqualone and its analogs are known to cause convulsions, this might also be the case for mebroqualone.

}}

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==Toxicity and harm potential==

[https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

Overdose of Mebroqualone can lead to seizures, coma or death. Taking [[toxicity::doses of over 300mg can be dangerous for first time users]]. Depending on the state of the user's individual tolerance, doses of about 8,000mg per day can be fatal whilst others on even higher doses (of up to 20,000mg) may survive.

Although the exact lethal dosage of Mebroqualone has not been formally established, like many [[depressants]], it is [[Toxicity::safe at appropriate dosages]]. Complications may arise when administered in excess or in combination with other depressants.

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==Legal status==

*'''Australia''' - Mebroqualone is Schedule 9 in Australia, meaning it is illegal without a license and deemed to have no medical value.

*'''Australia''' - Mebroqualone is Schedule 9 in Australia, meaning it is illegal without a license and deemed to have no medical value.{{citation needed}}

*'''Austria''' - Mebroqualone is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).

*'''Austria''' - Mebroqualone is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).{{citation needed}}

*'''Canada''' - Mebroqualone is Schedule III in Canada, meaning it requires a prescription or license to legally possess.

*'''Canada''' - Mebroqualone is Schedule III in Canada, meaning it requires a prescription or license to legally possess.{{citation needed}}

*'''Germany''' - Mebroqualone is Schedule III in Germany.

*'''Germany''' - Mebroqualone is Schedule III in Germany.{{citation needed}}

*'''United Kingdom''' - Mebroqualone is a Class B drug.

*'''United Kingdom''' - Mebroqualone is a Class B drug.{{citation needed}}

*'''United States''' - Mebroqualone is a Schedule I drug, and ~~is illegal to possess without a license~~.<ref>~~http~~://~~www~~.~~drugs~~.~~com~~/~~article~~/~~csa-schedule-1~~.~~html~~</ref>

*'''United States''' - Mebroqualone is unscheduled in the United States. It may be considered an analogue of Mecloqualone, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.<ref>https://deadiversion.usdoj.gov/schedules/orangebook/c_cs_alpha.pdf</ref>

==See also==

*[[Responsible use]]

*[[Depressants]]

*[[~~Mebroqualone~~]]

*[[Methaqualone]]

*[[GHB]]

@@ Line 4: / Line 4: @@
 {{SubstanceBox/Mebroqualone}}
-'''Mebroqualone''' (brand name '''Quaalude''' in the US and '''Mandrax''' in the UK) is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]]. The sedative–hypnotic activity of Mebroqualone was first noted by researchers in the 1950s and in 1962 Mebroqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational drug throughout the world. The drug was popular in the 1970s with hippies and in the disco club scene.
+'''Mebroqualone''' is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]].
+<!--
+The sedative–hypnotic activity of Mebroqualone was first noted by researchers in the 1950s and in 1962 Mebroqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational drug throughout the world. The drug was popular in the 1970s with hippies and in the disco club scene.{{citation needed}} --> <!-- where is a source for all this? i get a feeling this was copied from methaqualone
+-->
+Not much is known about this substance besides it being significantly more potent than [[methaqualone]] and shorter-lasting. It should be noted that methaqualone and its derivatives are prone to dangerous side effects such as respiratory depression and convulsions.{{citation needed}} It is therefore highly suggested to use [[harm reduction]] practices if using this substance.
 ==Chemistry==
@@ Line 10: / Line 15: @@
 ==Pharmacology==
+{{pharmacology}}
 Despite prior speculation, a 2015 study demonstrates that Mebroqualone exhibits distinct functional properties at the [[GABA]] [[receptor]] sites compared with other allosteric modulators, and it mediates these through a different mechanism than the [[barbiturates]] and [[benzodiazepines]] that it historically has been lumped together with.<ref name="ncbi qualuude study">A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Mebroqualone (Quaalude) (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/26056160</ref>
@@ Line 29: / Line 35: @@
 *'''[[Effect::Constipation]]'''
 *'''[[Effect::Changes in felt gravity]]'''
+*'''[[Effect::Seizures]]'''{{citation needed}} - Methaqualone and its analogs are known to cause convulsions, this might also be the case for mebroqualone.
 }}
@@ Line 57: / Line 64: @@
 ==Toxicity and harm potential==
 [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
-Overdose of Mebroqualone can lead to seizures, coma or death. Taking [[toxicity::doses of over 300mg can be dangerous for first time users]]. Depending on the state of the user's individual tolerance, doses of about 8,000mg per day can be fatal whilst others on even higher doses (of up to 20,000mg) may survive.
 Although the exact lethal dosage of Mebroqualone has not been formally established, like many [[depressants]], it is [[Toxicity::safe at appropriate dosages]]. Complications may arise when administered in excess or in combination with other depressants.
@@ Line 74: / Line 79: @@
 ==Legal status==
-*'''Australia''' - Mebroqualone is Schedule 9 in Australia, meaning it is illegal without a license and deemed to have no medical value.
+*'''Australia''' - Mebroqualone is Schedule 9 in Australia, meaning it is illegal without a license and deemed to have no medical value.{{citation needed}}
-*'''Austria''' - Mebroqualone is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).
+*'''Austria''' - Mebroqualone is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).{{citation needed}}
-*'''Canada''' - Mebroqualone is Schedule III in Canada, meaning it requires a prescription or license to legally possess.
+*'''Canada''' - Mebroqualone is Schedule III in Canada, meaning it requires a prescription or license to legally possess.{{citation needed}}
-*'''Germany''' - Mebroqualone is Schedule III in Germany.
+*'''Germany''' - Mebroqualone is Schedule III in Germany.{{citation needed}}
-*'''United Kingdom''' - Mebroqualone is a Class B drug.
+*'''United Kingdom''' - Mebroqualone is a Class B drug.{{citation needed}}
-*'''United States''' - Mebroqualone is a Schedule I drug, and is illegal to possess without a license.<ref>http://www.drugs.com/article/csa-schedule-1.html</ref>
+*'''United States''' - Mebroqualone is unscheduled in the United States. It may be considered an analogue of Mecloqualone, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.<ref>https://deadiversion.usdoj.gov/schedules/orangebook/c_cs_alpha.pdf</ref>
 ==See also==
 *[[Responsible use]]
 *[[Depressants]]
-*[[Mebroqualone]]
+*[[Methaqualone]]
 *[[GHB]]