Talk:Eutylone: Difference between revisions

'''Eutylone''' (also known as '''β-keto-1,3-benzodioxolyl-''N''-ethylbutanamine''', '''bk-EBDB''', '''''N''-Ethylbutylone''', or '''euty''') is a [[psychoactive class::stimulant]] which has been reported as a novel designer drug and has appeared in 2019 being sold as a designer drug.

As a [[designer drug]], it is commonly sold among [[research chemical]] vendors as a substitute for, or counterfeit of [[MDMA]] and [[methylone]], due to methylone's declining availability on the [[research chemical]] market. Despite behavioral and pharmacological similarities between eutylone and MDMA, the reported subjective effects of the two are not completely identical. Eutylone's effects are often described as being reminiscent of MDMA, but with a shorter duration and weaker effects.<ref name="urlCathinone | Ask Dr. Shulgin Online">{{cite web | url = http://www.cognitiveliberty.org/shulgin/adsarchive/cathinone.htm | title = Cathinone &#124; Ask Dr. Shulgin Online }}</ref>

Euthylone has a short history of human use and very little data exists about its pharmacological properties, metabolism, and toxicity. It is highly advised to use [[harm reduction practices]] if using this substance.

Eutylone is a synthetic substance of the [[Substituted cathinone|cathinone]] family.  Cathinones are structurally similar to amphetamines in that they contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional ethyl substitution at R{{Sub|α}}. Cathinones such as eutylone are alpha-methylated phenethylamines (i.e. [[amphetamine]]s) but differ from them with the addition of a ketone functional group (a carbonyl group at R_β).  

Eutylone acts as a mixed [[reuptake inhibitor]] and [[releasing agent]] of [[serotonin]], [[norepinephrine]], and [[dopamine]].<ref>Inhibition of plasma membrane monoamine transporters by beta-ketoamphetamines (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10528135</ref><ref>The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0014299906013811</ref> Eutylone modulates these[[neurotransmitters]] in charge of pleasure, reward, motivation and focus. This is done by inhibiting the reuptake and reabsorption of the neurotransmitters back into the cell after they have performed their function of transmitting a neural impulse, essentially allowing them to accumulate and be reused, causing physically stimulating and euphoric effects.  

In comparison to [[methylone]], it has much lower affinity for the norepinephrine transporter, while its affinity for the serotonin and dopamine transporters is similar.<ref>"Pharmacological characterization of designer cathinones in vitro" | http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02145.x/pdf</ref><ref>The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0014299906013811</ref> Despite this lower affinity, eutylone is a stronger [[reuptake inhibitor]] than [[MDMA]], although it is less potent and has a more balanced [[catecholaminergic]] profile. As a mixed releaser and reuptake inhibitor, it also has relatively robust releasing capabilities.<ref>"Pharmacological characterization of designer cathinones in vitro" | http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02145.x/pdf</ref>