Talk:Amisulpride: Difference between revisions

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 ==Chemistry==
 {{chemistry}}
+Amisulpride is the 4-position amino substitution of [[sulpiride]] which in turn is based on a [[chemical class::benzamide]] core.
 ==Pharmacology==
-{{pharmacology}}
+Amisulpride primarily works by antagonising D<sub>2</sub> and D<sub>3</sub> [[dopamine]] receptors aswell as the 5-HT<sub>7</sub>, 5-HT<sub>2A</sub> and 5-HT<sub>2B</sub> [[serotonin]] receptors.
+It is also known to act as a [[GHB receptor]] agonist and Mu- Delta- Kappa-[[opioid]] agonist<ref>Rehni AK, Singh TG, Chand P: Amisulpride-induced seizurogenic effect: a potential role of opioid receptor-linked transduction systems. Basic Clin Pharmacol Toxicol. 2011 May;108(5):310-7. doi: 10.1111/j.1742-7843.2010.00655.x. Epub 2010 Dec 22. (PubMed ID 21176108)</ref>
 ==Subjective effects==
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 |{{effects/physical|
-If applicable, a brief paragraph summary of the substance's physical effects may be included here.
-You may select physical effects to add below [[Subjective effect index#Physical effects|here]].
-*'''[[Effect::Physical effect]]'''
-*'''[[Effect::Physical effect2]]'''
-*'''[[Effect::Physical effect3]]'''
-}}
-{{effects/visual|
-If applicable, a brief paragraph summary of the substance's visual effects may be included here.
-You may select visual effects to add below [[Subjective effect index#Visual effects|here]].
-====Enhancements====
-*'''[[Effect::Visual acuity effect1]]'''
-====Distortions====
-*'''[[Effect::Visual distortion effect1]]'''
-====[[Effect::Geometry]]====
-If applicable, a brief paragraph summary describing the visual geometry produced by the substance may be included here.
-====Hallucinatory states====
-If applicable, a brief summary of the substance's visual effects profile may be written here.
-*'''[[Effect::Hallucinatory states1]]'''
+*'''[[Effect::Sedation]]'''
+*'''[[Effect::Increased salivation]]'''
+*'''[[Effect::Headaches]]'''
+*'''[[Effect::Nausea]]'''
+*'''[[Effect::Vomiting]]'''
+*'''[[Effect::Dry mouth]]''' anti-cholinergic effect
+*'''[[Effect::Constipation]]''' anti-cholinergic effect
+*'''[[Effect::Increased prolactin]]''' potentially causing the absence of the menstrual cycle, breast enlargement, breast milk secretion not related to breastfeeding, impaired fertility, impotence, breast pain, etc
 }}
 |{{effects/cognitive|
-If applicable, a brief paragraph summary of the substance's cognitive effects may be included here.
-You may select from a list of cognitive effects to add below [[Subjective effect index#Cognitive effects|here]].
-*'''[[Effect::Cognitive effect1]]'''
-*'''[[Effect::Cognitive effect2]]'''
-*'''[[Effect::Cognitive effect3]]'''
-}}
-{{effects/auditory|
-If applicable, a brief paragraph summary of the substance's auditory effects may be included here.
-You may select from a list of auditory effects to add below [[Subjective effect index#Auditory effects|here]].
-*'''[[Effect::Auditory effect1]]'''
-*'''[[Effect::Auditory effect2]]'''
-}}
-{{effects/multisensory|
-If applicable, a brief paragraph summary of the substance's multisensory effects may be included here.
-You may select from a list of multisensory effects to add below [[Subjective effect index#Multisensory effects|here]].
-*'''[[Effect::Multisensory effect1]]'''
-*'''[[Effect::Multisensory effect2]]'''
-}}
-{{effects/transpersonal|
-If applicable, a brief paragraph summary of the substance's transpersonal effects may be included here.
-You may select from a list of transpersonal effects to add below [[Subjective effect index#Transpersonal effects|here]].
-*'''[[Effect::Transpersonal effect1]]'''
+*'''[[Effect::Thought deceleration]]'''
-*'''[[Effect::Transpersonal effect2]]'''
+*'''[[Effect::Thought acceleration]]''' contradictory side effect
+*'''[[Effect::Dream potentiation]]'''
 }}
@@ Line 102: / Line 58: @@
 ==Legal status==
 {{LegalStub}}
+*'''Australia''': Amisulpride is a Schedule 4 prescription only drug.{{citation needed}}
+*'''Brazil''': Amisulpride is a Class C1 prescription only drug.<ref>https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992</ref>
+*'''United Kingdom''': Amisulpride is a prescription only drug.<ref>https://web.archive.org/web/20200226225750/https://www.medicines.org.uk/emc/product/2726/smpc</ref>
+*'''United States''': Amisulpride is a prescription only drug.{{citation needed}}
 ==See also==
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 *[https://isomerdesign.com/PiHKAL/explore.php?id=9407 Amisulpride (Isomer Design)]
 *[https://go.drugbank.com/drugs/DB06288 Amisulpride (DrugBank)]
+*[https://www.drugs.com/mtm/amisulpride.html#dosage Amisulpride (Drugs.com)]
-==Literature==
-* APA formatted reference
-Please see the [[citation formatting guide]] if you need assistance properly formatting citations.
 ==References==
@@ Line 122: / Line 78: @@
 [[Category:Antipsychotic]]
 [[Category:Atypical Neuroleptic]]
+[[Category:Opioid]]
+[[Category:Benzamide]]
 [[Category:Psychoactive substance]]
 [[Category:Proofread]]
 [[Category:Approval]]