Agonist: Difference between revisions - PsychonautWiki Archive

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[[File:Efficacy spectrum.png|thumbnail|275px|Efficacy spectrum of receptor ligands]]

[[File:Inverse_agonist_3.svg|thumbnail|275px|Dose response curves of receptor ligands]]

An '''agonist''' is a chemical that binds to the [[receptor]] of a cell and activates the receptor to cause a physiological response. An agonist initiates the same reaction typically produced by the binding of an endogenous ligand (such as a hormone or neurotransmitter) with a receptor.<ref>~~Agonist definition (Merriam-Webster) http~~://www.merriam-webster.com/dictionary/agonist</ref> A substance's ability to affect a given receptor is dependent on the substance's affinity and intrinsic efficacy towards that receptor. The affinity of a substance describes the strength of attraction between it and a given receptor, and consequently its ability to bind to that receptor. A substance with a high affinity for a receptor has a high likelihood of binding to it, while a substance with a low affinity has a lesser degree of attraction towards a receptor.

An '''agonist''' is a chemical that binds to the [[receptor]] of a cell and activates the receptor to cause a physiological response. An agonist initiates the same reaction typically produced by the binding of an endogenous ligand (such as a hormone or neurotransmitter) with a receptor.<ref>{{Citation | title=Definition of AGONIST | url=https://www.merriam-webster.com/dictionary/agonist}}</ref> A substance's ability to affect a given receptor is dependent on the substance's affinity and intrinsic efficacy towards that receptor. The affinity of a substance describes the strength of attraction between it and a given receptor, and consequently its ability to bind to that receptor. A substance with a high affinity for a receptor has a high likelihood of binding to it, while a substance with a low affinity has a lesser degree of attraction towards a receptor.

This contrasts the efficacy of a substance, which describes a substance's capacity to produce a response when bound to a receptor. A substance with high efficacy will produce a proportionally stronger effect than a substance of lower efficacy occupying the same number of receptors. The maximum efficacy of a substance reflects the greatest attainable response to a particular substance on a receptor set regardless of dose. A substance with a high efficacy may need to occupy fewer receptors to produce maximum effects, meaning it will not produce stronger effects beyond a certain dosage.

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[[Category:Pharmacology]]

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 [[File:Efficacy spectrum.png|thumbnail|275px|Efficacy spectrum of receptor ligands]]
 [[File:Inverse_agonist_3.svg|thumbnail|275px|Dose response curves of receptor ligands]]
-An '''agonist''' is a chemical that binds to the [[receptor]] of a cell and activates the receptor to cause a physiological response. An agonist initiates the same reaction typically produced by the binding of an endogenous ligand (such as a hormone or neurotransmitter) with a receptor.<ref>Agonist definition (Merriam-Webster) http://www.merriam-webster.com/dictionary/agonist</ref> A substance's ability to affect a given receptor is dependent on the substance's affinity and intrinsic efficacy towards that receptor. The affinity of a substance describes the strength of attraction between it and a given receptor, and consequently its ability to bind to that receptor. A substance with a high affinity for a receptor has a high likelihood of binding to it, while a substance with a low affinity has a lesser degree of attraction towards a receptor.
+An '''agonist''' is a chemical that binds to the [[receptor]] of a cell and activates the receptor to cause a physiological response. An agonist initiates the same reaction typically produced by the binding of an endogenous ligand (such as a hormone or neurotransmitter) with a receptor.<ref>{{Citation | title=Definition of AGONIST | url=https://www.merriam-webster.com/dictionary/agonist}}</ref> A substance's ability to affect a given receptor is dependent on the substance's affinity and intrinsic efficacy towards that receptor. The affinity of a substance describes the strength of attraction between it and a given receptor, and consequently its ability to bind to that receptor. A substance with a high affinity for a receptor has a high likelihood of binding to it, while a substance with a low affinity has a lesser degree of attraction towards a receptor.
 This contrasts the efficacy of a substance, which describes a substance's capacity to produce a response when bound to a receptor. A substance with high efficacy will produce a proportionally stronger effect than a substance of lower efficacy occupying the same number of receptors. The maximum efficacy of a substance reflects the greatest attainable response to a particular substance on a receptor set regardless of dose. A substance with a high efficacy may need to occupy fewer receptors to produce maximum effects, meaning it will not produce stronger effects beyond a certain dosage.
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 [[Category:Pharmacology]]
+{{#set:Featured=true}}