Talk:Estradiol: Difference between revisions

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 {{SubstanceBox/Estradiol}}
-'''Estradiol''' (also known as '''estrogen''', '''oestradiol''', '''E''' or '''E2''') is a steroid hormone and the major female sex hormone.
+'''Estradiol''' (also known as '''oestradiol''', '''E''' or '''E2''') is an [[estrogen]] steroid hormone and the major female sex hormone.
 ==History and culture==
-{{historyStub}}
+It is a basic, natural estrogen. Chemically, it is a steroid, a derivative of estrone.
+Responsible for the development of the female reproductive organs, proliferation of the endometrium, regulates the sexual cycle and affects sexual behavior. During the follicular phase, it is produced mainly in the ovaries by growing Graaf follicles. In the corpus luteum phase, it is secreted in very small amounts by the corpus luteum. It is also produced in the adrenal cortex and during pregnancy in the placenta.
 ==Chemistry==
-{{chemistry}}
+===Esters===
+As a medication '''estradiol''' is commonly(especially when injected) administered in the form of [[prodrug]] esters to improve duration of action.
+{| class="wikitable"
+|-
+! scope="col" |'''Compound'''
+! scope="col" |'''Halflife via IM'''
+! scope="col" |'''Structure'''
+|-
+|[[Estradiol Valerate]]||1.2–7.2 days||[[File:estradiol_valerate.svg|200px]]
+|-
+|[[Estradiol Cypionate]]||8–10 days||[[File:estradiol_cypionate.svg|200px]]
+|-
+|[[Estradiol Enantate]]||5.6–7.5 days||[[File:estradiol_enantate.svg|200px]]
+|-
+|[[Estradiol Undecylate]]||~1 month||[[File:estradiol_undecylate.svg|200px]]
+|-
+|}
 ==Pharmacology==
 {{pharmacology}}
 ==Subjective effects==
-{{EffectStub}}
 {{Preamble/SubjectiveEffects}}
 {{effects/base
+|{{effects/physical|
-|{{effects/physical|
+'''Estradiol''' has feminzing develomental effects on the human body in regards of fat distribution, muscles mass and sexual characteristics.
+*'''[[Effect::Decreased libido]]'''
+*'''[[Effect::Orgasm depression]]'''
+*'''[[Effect::Body odor alteration]]'''
+*'''[[Effect::Body fat redistribution]]'''
+*'''[[Effect::Breast growth]]'''
+*'''[[Effect::Reduction of body hair]]'''
+*'''[[Effect::Softening of the skin]]'''
+}}
+|{{effects/cognitive|
+*'''[[Effect::Empathy, affection, and sociability enhancement]]'''
+*'''[[Effect::Cognitive euphoria]]''' Estradiol may directly produce feelings of euphoria in feminine people aswell as added euphoria due to gender affirming physical effects.
+*'''[[Effect::Cognitive dysphoria]]''' Estradiol might produce gender-dysphoria in masculine people
 }}
+{{effects/transpersonal|
+*'''[[Effect::Identity alteration]]'''
-|{{effects/cognitive|
-*'''[[Effect::Cognitive effect1]]'''
 }}
 }}
 ===Experience reports===
 There are currently {{#ask:[[Category:Estradiol]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
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 ==External links==
+*[https://en.wikipedia.org/wiki/Estradiol Estradiol (Wikipedia)]
-* [https://en.wikipedia.org/wiki/Estradiol Estradiol (Wikipedia)]
+*[https://go.drugbank.com/drugs/DB00783 Estradiol (DrugBank)]
+*[https://www.drugs.com/estradiol.html Estradiol (Drugs.com)]
 ==References==
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 [[Category:Psychoactive substance]]
 [[Category:Hormone]]
+[[Category:Estrogen]]
 [[Category:Proofread]]
 [[Category:Approval]]