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Talk:Etomidate: Difference between revisions
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|EffectClass=[[Psychoactive class:: | |EffectClass=[[Psychoactive class::Depressants]] | ||
|ChemicalClass=[[chemical class::Cathinone]] | |ChemicalClass=[[chemical class::Cathinone]] | ||
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{{chemistry}} | {{chemistry}} | ||
==Pharmacology== | ==Pharmacology== | ||
{{pharmacology}} | {{pharmacology}} | ||
Etomidate is an imidazole-derived, non-barbiturate, short-acting intravenous anesthetic. The etomidate distribution model conforms to the three-compartment drug distribution model, and the distribution volume is 2.2-4.5L/kg. Because of its high binding capacity to serum proteins and rapid drug metabolism, the time-dose-related half-life does not extend significantly with continuous infusion. It is not only suitable for single administration during induction, but also for intraoperative maintenance. The site of action of intravenous anesthetics is generally related to gamma-aminobutyric acid, and the important target of etomidate's molecular mechanism of action is the GABA-A receptor. | |||
Forman found in experimental studies that different concentrations of etomidate act on GABA-A receptors in different ways. Commonly used doses of etomidate are similar to GABA-A receptor agonists, prolonging the decay time of postsynaptic inhibitory currents, lengthening the duration of inhibition, and also activating extrasynaptic GABA receptors. Excessive doses of etomidate act directly on GABA-A receptors and are similar to GABA allosteric activators. Studies have found that etomidate not only acts on GABA receptors, but also on α-2β adrenergic receptors, thereby causing vasoconstriction and maintaining hemodynamic stability.<ref>[https://www.sohu.com/a/343157114_668064#google_vignette 依托咪酯持续输注在临床中的应用], additional text.</ref> | |||
==Subjective effects== | ==Subjective effects== | ||
{{EffectStub}} | {{EffectStub}} | ||
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You may select physical effects to add below [[Subjective effect index#Physical effects|here]]. | You may select physical effects to add below [[Subjective effect index#Physical effects|here]]. | ||
*'''[[Effect:: | *'''[[Effect::Motor control loss]]'''<ref>[https://www.bilibili.com/video/BV1ZG411B7QW/ Abuse etomidate can be motor control loss], 禁毒宣传：滥用右美沙芬者的状态</ref> | ||
*'''[[Effect::Physical effect2]]''' | *'''[[Effect::Physical effect2]]''' | ||
*'''[[Effect::Physical effect3]]''' | *'''[[Effect::Physical effect3]]''' | ||
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You may select from a list of cognitive effects to add below [[Subjective effect index#Cognitive effects|here]]. | You may select from a list of cognitive effects to add below [[Subjective effect index#Cognitive effects|here]]. | ||
*'''[[Effect:: | *'''[[Effect::Irritability]]''' Excessive use of etomidate can cause irritability | ||
*'''[[Effect::Cognitive effect2]]''' | *'''[[Effect::Cognitive effect2]]''' | ||
*'''[[Effect::Cognitive effect3]]''' | *'''[[Effect::Cognitive effect3]]''' | ||