4-HO-DET: Difference between revisions

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'''4-Hydroxy-N,N-diethyltryptamine''' (also known as '''4-HO-DET''', '''CZ-74''', and '''Ethocin''') is a lesser-known synthetic [[psychoactive class::psychedelic]] of the [[chemical class::tryptamine]] chemical class that produces [[psilocin]]-like [[psychedelic]] effects when [[Routes of administration|adminstered]]. 4-HO-DET is a close structural and functional analog of [[psilocin]] (4-HO-DMT), the principal psychoactive component in [[magic mushrooms]]. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects.

This compound was first discovered in the late 1950s by [[wikipedia:Albert Hofmann|Albert Hofmann]] and Franz Troxler<ref>{{cite web|title=US Patent 3072530 - Therapeutic indoles for psychic stimulation and relief of mental depression|url=https://patents.google.com/patent/US3072530/en|access-date=July 18, 2020|website=Google Patents}}</ref><ref>{{cite web|url=https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf|publisher=United States Patent Office|title=Esters of Indoles|date=January 29, 1963|id=3,075,992}}</ref> in their investigation of various [[psychedelic]] compounds that were structurally and chemically related to the principle active components he isolated from [[magic mushrooms]], [[psilocybin]] ('''4-PO-DMT''') and [[psilocin]] ('''4-HO-DMT'''). The substance was used together with its phosphoryloxy-analog [[wikipedia:4-PO-DET|4-PO-DET]] in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer.~~{{citation needed}}~~

This compound was first discovered in the late 1950s by [[wikipedia:Albert Hofmann|Albert Hofmann]] and Franz Troxler<ref>{{cite web|title=US Patent 3072530 - Therapeutic indoles for psychic stimulation and relief of mental depression|url=https://patents.google.com/patent/US3072530/en|access-date=July 18, 2020|website=Google Patents}}</ref><ref>{{cite web|url=https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf|publisher=United States Patent Office|title=Esters of Indoles|date=January 29, 1963|id=3,075,992}}</ref> in their investigation of various [[psychedelic]] compounds that were structurally and chemically related to the principle active components he isolated from [[magic mushrooms]], [[psilocybin]] ('''4-PO-DMT''') and [[psilocin]] ('''4-HO-DMT'''). The substance was used together with its phosphoryloxy-analog [[wikipedia:4-PO-DET|4-PO-DET]] in human clinical trials in the 1960s by the German researchers Hanscarl Leuner <ref>"Psycholytische Therapie nach Hanscarl Leuner – Grundlagen, Praxis, Perspektiven" (in German), Torsten Passie, Michael Schlichting, Ralf Bolle (published September, 2023).</ref> and G. Baer.

Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of [[psychedelic]] users preferring more traditional [[psychedelics]] like the [[psilocybin]] and [[psilocin]] in [[psilocybin mushrooms]], or more recently, [[4-AcO-DMT]]. Today, it is either used as a recreational substance or an [[entheogen]], has no documentation of being sold on the streets and is primarily acquired through the use of online [[research chemical]] vendors.

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 '''4-Hydroxy-N,N-diethyltryptamine'''  (also known as '''4-HO-DET''', '''CZ-74''', and '''Ethocin''') is a lesser-known synthetic [[psychoactive class::psychedelic]] of the [[chemical class::tryptamine]] chemical class that produces [[psilocin]]-like [[psychedelic]] effects when [[Routes of administration|adminstered]]. 4-HO-DET is a close structural and functional analog of [[psilocin]] (4-HO-DMT), the principal psychoactive component in [[magic mushrooms]]. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects.
-This compound was first discovered in the late 1950s by [[wikipedia:Albert Hofmann|Albert Hofmann]] and Franz Troxler<ref>{{cite web|title=US Patent 3072530 -  Therapeutic indoles for psychic stimulation and relief of mental depression|url=https://patents.google.com/patent/US3072530/en|access-date=July 18, 2020|website=Google Patents}}</ref><ref>{{cite web|url=https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf|publisher=United States Patent Office|title=Esters of Indoles|date=January 29, 1963|id=3,075,992}}</ref> in their investigation of various [[psychedelic]] compounds that were structurally and chemically related to the principle active components he isolated from [[magic mushrooms]], [[psilocybin]] ('''4-PO-DMT''') and [[psilocin]] ('''4-HO-DMT'''). The substance was used together with its phosphoryloxy-analog [[wikipedia:4-PO-DET|4-PO-DET]] in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer.{{citation needed}}
+This compound was first discovered in the late 1950s by [[wikipedia:Albert Hofmann|Albert Hofmann]] and Franz Troxler<ref>{{cite web|title=US Patent 3072530 -  Therapeutic indoles for psychic stimulation and relief of mental depression|url=https://patents.google.com/patent/US3072530/en|access-date=July 18, 2020|website=Google Patents}}</ref><ref>{{cite web|url=https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf|publisher=United States Patent Office|title=Esters of Indoles|date=January 29, 1963|id=3,075,992}}</ref> in their investigation of various [[psychedelic]] compounds that were structurally and chemically related to the principle active components he isolated from [[magic mushrooms]], [[psilocybin]] ('''4-PO-DMT''') and [[psilocin]] ('''4-HO-DMT'''). The substance was used together with its phosphoryloxy-analog [[wikipedia:4-PO-DET|4-PO-DET]] in human clinical trials in the 1960s by the German researchers Hanscarl Leuner <ref>"Psycholytische Therapie nach Hanscarl Leuner – Grundlagen, Praxis, Perspektiven" (in German), Torsten Passie, Michael Schlichting, Ralf Bolle (published September, 2023).</ref> and G. Baer.
 Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of [[psychedelic]] users preferring more traditional [[psychedelics]] like the [[psilocybin]] and [[psilocin]] in [[psilocybin mushrooms]], or more recently, [[4-AcO-DMT]]. Today, it is either used as a recreational substance or an [[entheogen]], has no documentation of being sold on the streets and is primarily acquired through the use of online [[research chemical]] vendors.