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4-HO-DET: Difference between revisions

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'''4-Hydroxy-N,N-diethyltryptamine'''  (also known as '''4-HO-DET''', '''CZ-74''', and '''Ethocin''') is a lesser-known synthetic [[psychoactive class::psychedelic]] of the [[chemical class::tryptamine]] chemical class that produces [[psilocin]]-like [[psychedelic]] effects when [[Routes of administration|adminstered]]. 4-HO-DET is a close structural and functional analog of [[psilocin]] (4-HO-DMT), the principal psychoactive component in [[magic mushrooms]]. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects.
'''4-Hydroxy-N,N-diethyltryptamine'''  (also known as '''4-HO-DET''', '''CZ-74''', and '''Ethocin''') is a lesser-known synthetic [[psychoactive class::psychedelic]] of the [[chemical class::tryptamine]] chemical class that produces [[psilocin]]-like [[psychedelic]] effects when [[Routes of administration|adminstered]]. 4-HO-DET is a close structural and functional analog of [[psilocin]] (4-HO-DMT), the principal psychoactive component in [[magic mushrooms]]. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects.


This compound was first discovered in the late 1950s by [[wikipedia:Albert Hofmann|Albert Hofmann]] and Franz Troxler<ref>Therapeutic indoles for psychic stimulation and relief of mental depression | http://www.google.com/patents/US3072530</ref><ref>United States Patent Office | https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf</ref> in their investigation of various [[psychedelic]] compounds that were structurally and chemically related to the principle active components he isolated from [[magic mushrooms]], [[psilocybin]] ('''4-PO-DMT''') and [[psilocin]] ('''4-HO-DMT'''). The substance was used together with its phosphoryloxy-analog [[wikipedia:4-PO-DET|4-PO-DET]] in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer.{{citation needed}}
This compound was first discovered in the late 1950s by [[wikipedia:Albert Hofmann|Albert Hofmann]] and Franz Troxler<ref>{{cite web|title=US Patent 3072530 -  Therapeutic indoles for psychic stimulation and relief of mental depression|url=https://patents.google.com/patent/US3072530/en|access-date=July 18, 2020|website=Google Patents}}</ref><ref>{{cite web|url=https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf|publisher=United States Patent Office|title=Esters of Indoles|date=January 29, 1963|id=3,075,992}}</ref> in their investigation of various [[psychedelic]] compounds that were structurally and chemically related to the principle active components he isolated from [[magic mushrooms]], [[psilocybin]] ('''4-PO-DMT''') and [[psilocin]] ('''4-HO-DMT'''). The substance was used together with its phosphoryloxy-analog [[wikipedia:4-PO-DET|4-PO-DET]] in human clinical trials in the 1960s by the German researchers Hanscarl Leuner <ref>"Psycholytische Therapie nach Hanscarl Leuner – Grundlagen, Praxis, Perspektiven" (in German), Torsten Passie, Michael Schlichting, Ralf Bolle (published September, 2023).</ref> and G. Baer.  


Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of [[psychedelic]] users preferring more traditional [[psychedelics]] like the [[psilocybin]] and [[psilocin]] in [[psilocybin mushrooms]], or more recently, [[4-AcO-DMT]]. Today, it is either used as a recreational substance or an [[entheogen]], has no documentation of being sold on the streets and is primarily acquired through the use of online [[research chemical]] vendors.
Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of [[psychedelic]] users preferring more traditional [[psychedelics]] like the [[psilocybin]] and [[psilocin]] in [[psilocybin mushrooms]], or more recently, [[4-AcO-DMT]]. Today, it is either used as a recreational substance or an [[entheogen]], has no documentation of being sold on the streets and is primarily acquired through the use of online [[research chemical]] vendors.
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*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::External hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')


}}
}}
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4-HO-DET is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  
4-HO-DET is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  


Tolerance to the effects of 4-HO-DET are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-DET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-DET all psychedelics will have a reduced effect.
Tolerance to the effects of 4-HO-DET is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-DET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-DET all psychedelics will have a reduced effect.


===Dangerous interactions===
===Dangerous interactions===
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{{DangerousInteractions/Psychedelics}}
{{DangerousInteractions/Psychedelics}}


==Legality==
==Legal status==
{{legalStub}}
{{legalStub}}


*'''Germany:''' 4-HO-DET is controlled under the NpSG as of July 18, 2019. <ref>https://www.buzer.de/gesetz/12250/v224771-2019-07-18.htm</ref> <ref>https://www.gesetze-im-internet.de/npsg/anlage.html</ref> Production and import for placing on the market and trade is punishable. Possession, although illegal, is not penalized if not intended for sale.<ref>https://www.gesetze-im-internet.de/npsg/__4.html</ref>
*'''Germany''': 4-HO-DET is controlled under Anlage I BtMG<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html|title=Gesetz über den Verkehr mit Betäubungsmitteln: Anlage I|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''Narcotics Act, Schedule I''), former: Opiumgesetz (''Opium Act'') as of February 25, 1967.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl167s0197.pdf|title=Vierte Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Teil I: 1967 Nr. 10|publication-date=February 24, 1967|language=de|issn=0341-1095|page=197|}}</ref> It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/__29.html|title=Gesetz über den Verkehr mit Betäubungsmitteln: § 29|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref>
*'''United Kingdom:''' 4-HO-DET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e</ref>
*'''Sweden:''' 4-HO-DET is classified as a health hazard under the Act on the Prohibition of Certain Goods Dangerous to Health as of November 1, 2005 in the regulation SFS 2005:733, making it illegal to sell or possess.<ref>{{cite web|title=Svensk författningssamling Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor|url=http://www.notisum.se/rnp/sls/sfs/20050733.pdf|id=SFS 2005:733|language=sv|date=October 6, 2005|publication-date=October 18, 2005|}}</ref>
*'''United States:''' 4-HO-DET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}
*'''Switzerland''': 4-HO-DET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''Sweden:''' 4-HO-DET is classified as a health hazard under the Act on the Prohibition of Certain Goods Dangerous to Health as of November 1, 2005 in the regulation SFS 2005:733, making it illegal to sell or possess.<ref>Svensk författningssamling | http://www.notisum.se/rnp/sls/sfs/20050733.pdf</ref>
*'''United Kingdom''': 4-HO-DET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
*'''United States''': 4-HO-DET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}


==See also==
==See also==
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*[https://en.wikipedia.org/wiki/4-HO-DET 4-HO-DET (Wikipedia)]
*[https://en.wikipedia.org/wiki/4-HO-DET 4-HO-DET (Wikipedia)]
*[https://erowid.org/chemicals/4_acetoxy_det/ 4-HO-DET (Erowid Vault)]
*[https://isomerdesign.com/PiHKAL/read.php?domain=tk&id=16 4-HO-DET  (TiHKAL / Isomer Design)]
*[https://isomerdesign.com/PiHKAL/read.php?domain=tk&id=16 4-HO-DET  (TiHKAL / Isomer Design)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=5057 4-HO-DET phosphate ester (Isomer Design)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=5057 4-HO-DET phosphate ester (Isomer Design)]
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==References==
==References==
<references />
<references />
[[Category:Substance]]
[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Research chemical]]
[[Category:Hallucinogen]]
[[Category:Hallucinogen]]
[[Category:Psychedelic]]
[[Category:Psychedelic]]
[[Category:Tryptamine]]
[[Category:Tryptamine]]
[[Category:Research chemical]]
{{#set:Featured=true}}
{{#set:Featured=true}}
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