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4-HO-DET: Difference between revisions

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{{SummarySheet}}
{{SubstanceBox/4-HO-DET}}
{{SubstanceBox/4-HO-DET}}
{|
 
|-
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| ''[[4-HO-DET/Summary|Summary sheet: 4-HO-DET]]''
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'''4-Hydroxy-N,N-diethyltryptamine'''  (also known as '''4-HO-DET''', '''CZ-74''', and '''Ethocin''') is a lesser-known synthetic [[psychoactive class::psychedelic]] of the [[chemical class::tryptamine]] chemical class that produces [[psilocin]]-like [[psychedelic]] effects when [[Routes of administration|adminstered]]. 4-HO-DET is a close structural and functional analog of [[psilocin]] (4-HO-DMT), the principal psychoactive component in [[magic mushrooms]]. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects.
'''4-Hydroxy-N,N-diethyltryptamine'''  (also known as '''4-HO-DET''', '''CZ-74''', and '''Ethocin''') is a lesser-known synthetic [[psychoactive class::psychedelic]] of the [[chemical class::tryptamine]] chemical class that produces [[psilocin]]-like [[psychedelic]] effects when [[Routes of administration|adminstered]]. 4-HO-DET is a close structural and functional analog of [[psilocin]] (4-HO-DMT), the principal psychoactive component in [[magic mushrooms]]. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects.


This compound was first discovered in the late 1950s by [[Albert Hofmann]] and Franz Troxler<ref>Therapeutic indoles for psychic stimulation and relief of mental depression | http://www.google.com/patents/US3072530</ref><ref>United States Patent Office | https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf</ref> in their investigation of various [[psychedelic]] compounds that were structurally and chemically related to the principle active components he isolated from [[magic mushrooms]], [[psilocybin]] ('''4-PO-DMT''') and [[psilocin]] ('''4-HO-DMT'''). The substance was used together with its phosphoryloxy-analog [[4-PO-DET]] in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer.{{citation needed}}
This compound was first discovered in the late 1950s by [[wikipedia:Albert Hofmann|Albert Hofmann]] and Franz Troxler<ref>{{cite web|title=US Patent 3072530 -  Therapeutic indoles for psychic stimulation and relief of mental depression|url=https://patents.google.com/patent/US3072530/en|access-date=July 18, 2020|website=Google Patents}}</ref><ref>{{cite web|url=https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf|publisher=United States Patent Office|title=Esters of Indoles|date=January 29, 1963|id=3,075,992}}</ref> in their investigation of various [[psychedelic]] compounds that were structurally and chemically related to the principle active components he isolated from [[magic mushrooms]], [[psilocybin]] ('''4-PO-DMT''') and [[psilocin]] ('''4-HO-DMT'''). The substance was used together with its phosphoryloxy-analog [[wikipedia:4-PO-DET|4-PO-DET]] in human clinical trials in the 1960s by the German researchers Hanscarl Leuner <ref>"Psycholytische Therapie nach Hanscarl Leuner – Grundlagen, Praxis, Perspektiven" (in German), Torsten Passie, Michael Schlichting, Ralf Bolle (published September, 2023).</ref> and G. Baer.  


Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of [[psychedelic]] users preferring more traditional [[psychedelics]] like the [[psilocybin]] and [[psilocin]] in [[psilocybin mushrooms]], or more recently, [[4-AcO-DMT]]. Today, it is either used as a recreational substance or an [[entheogen]], has no documentation of being sold on the streets and is primarily acquired through the use of online [[research chemical]] vendors.
Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of [[psychedelic]] users preferring more traditional [[psychedelics]] like the [[psilocybin]] and [[psilocin]] in [[psilocybin mushrooms]], or more recently, [[4-AcO-DMT]]. Today, it is either used as a recreational substance or an [[entheogen]], has no documentation of being sold on the streets and is primarily acquired through the use of online [[research chemical]] vendors.
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{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
===Physical effects===
{{effects/base
|{{effects/physical|
*'''[[Effect::Spontaneous physical sensations]]'''
*'''[[Effect::Spontaneous physical sensations]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Tactile enhancement]]'''
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*'''[[Effect::Frequent urination]]'''
*'''[[Effect::Frequent urination]]'''
*'''[[Effect::Muscle contractions]]'''
*'''[[Effect::Muscle contractions]]'''
*'''[[Effect::Olfactory hallucinations]]'''
*'''[[Effect::Olfactory hallucination]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Runny nose]]'''
*'''[[Effect::Runny nose]]'''


===Cognitive effects===
}}
The cognitive effects of 4-HO-DET can be described as mildly more stimulating and lucid in style when compared to other similar psychedelics such as [[psilocybin]] or [[2C-C]] which tend to be more sedating. It has also been characterized as possessing a more "neutral", "analytical" headspace with minimal memory disruptions or emotional confusion compared to [[psilocybin mushrooms]].
 
The most prominent of these typical effects generally include:
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased sense of humor]]'''
**'''[[Effect::Laughter fits]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought connectivity]]'''
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Wakefulness]]'''


===Visual effects===
{{effects/visual|
====Enhancements====
====Enhancements====
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Colour enhancement]]'''
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*'''[[Effect::Machinescapes]]'''
*'''[[Effect::Machinescapes]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::External hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')


===Auditory effects===
}}
 
|{{effects/cognitive|
The cognitive effects of 4-HO-DET can be described as mildly more stimulating and lucid in style when compared to other similar psychedelics such as [[psilocybin]] or [[2C-C]] which tend to be more sedating. It has also been characterized as possessing a more "neutral", "analytical" headspace with minimal memory disruptions or emotional confusion compared to [[psilocybin mushrooms]].
 
The most prominent of these typical effects generally include:
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased sense of humor]]'''
**'''[[Effect::Laughter fits]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought connectivity]]'''
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Wakefulness]]'''
 
}}
 
{{effects/auditory|
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
}}
}}


===Experience reports===
===Experience reports===
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{{#ask: [[Category:4-HO-DET]][[Category:Experience]]|format=ul|Columns=1}}
{{#ask: [[Category:4-HO-DET]][[Category:Experience]]|format=ul|Columns=1}}
Additional experience reports can be found here:
Additional experience reports can be found here:
* [https://www.erowid.org/experiences/subs/exp_4HODET.shtml Erowid Experience Vaults: 4-HO-DET]
 
*[https://www.erowid.org/experiences/subs/exp_4HODET.shtml Erowid Experience Vaults: 4-HO-DET]


==Toxicity and harm potential==
==Toxicity and harm potential==
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4-HO-DET is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  
4-HO-DET is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  


Tolerance to the effects of 4-HO-DET are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-DET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-DET all psychedelics will have a reduced effect.
Tolerance to the effects of 4-HO-DET is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-DET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-DET all psychedelics will have a reduced effect.
 
===Dangerous interactions===
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Psychedelics}}


==Legality==
==Legal status==
{{legalStub}}
{{legalStub}}
*'''United Kingdom''' - 4-HO-DET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e</ref>
 
*'''United States''' - 4-HO-DET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}
*'''Germany''': 4-HO-DET is controlled under Anlage I BtMG<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html|title=Gesetz über den Verkehr mit Betäubungsmitteln: Anlage I|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''Narcotics Act, Schedule I''), former: Opiumgesetz (''Opium Act'') as of February 25, 1967.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl167s0197.pdf|title=Vierte Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Teil I: 1967 Nr. 10|publication-date=February 24, 1967|language=de|issn=0341-1095|page=197|}}</ref> It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/__29.html|title=Gesetz über den Verkehr mit Betäubungsmitteln: § 29|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref>
*'''Sweden''' - 4-HO-DET is classified as a health hazard under the Act on the Prohibition of Certain Goods Dangerous to Health as of November 1, 2005 in the regulation SFS 2005:733, making it illegal to sell or possess.<ref>Svensk författningssamling | http://www.notisum.se/rnp/sls/sfs/20050733.pdf</ref>
*'''Sweden:''' 4-HO-DET is classified as a health hazard under the Act on the Prohibition of Certain Goods Dangerous to Health as of November 1, 2005 in the regulation SFS 2005:733, making it illegal to sell or possess.<ref>{{cite web|title=Svensk författningssamling Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor|url=http://www.notisum.se/rnp/sls/sfs/20050733.pdf|id=SFS 2005:733|language=sv|date=October 6, 2005|publication-date=October 18, 2005|}}</ref>
*'''Switzerland''': 4-HO-DET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': 4-HO-DET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
*'''United States''': 4-HO-DET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Research chemical]]
*[[Research chemical]]
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*[[DET]]
*[[DET]]


==External links==


==External links==
*[https://en.wikipedia.org/wiki/4-HO-DET 4-HO-DET (Wikipedia)]
*[https://en.wikipedia.org/wiki/4-HO-DET 4-HO-DET (Wikipedia)]
*[https://www.erowid.org/library/books_online/tihkal/tihkal16.shtml 4-HO-DET (TiHKAL)]
*[https://isomerdesign.com/PiHKAL/read.php?domain=tk&id=16 4-HO-DET  (TiHKAL / Isomer Design)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=5057 4-HO-DET phosphate ester (Isomer Design)]
*[http://www.bluelight.org/vb/threads/480200-The-Big-amp-Dandy-4-HO-DET-Thread 4-HO-DET (Bluelight)]
*[http://www.bluelight.org/vb/threads/480200-The-Big-amp-Dandy-4-HO-DET-Thread 4-HO-DET (Bluelight)]
*[http://www.erowid.org/chemicals/4_acetoxy_det/4_acetoxy_det_article1.shtml 4-AcO-DET degradation (Erowid)]


==References==
==References==
<references/>
<references />
 
[[Category:Substance]]
[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Research chemical]]
[[Category:Hallucinogen]]
[[Category:Psychedelic]]
[[Category:Psychedelic]]
[[Category:Tryptamine]]
[[Category:Tryptamine]]
[[Category:Research chemical]]
{{#set:Featured=true}}
{{#set:Featured=true}}
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