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MXiPr: Difference between revisions
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The circumstances surrounding MXiPr's origins are not known. It first appeared on the online research chemical market in late 2020<ref>MXiPr - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=MXiPr</ref> and was specifically marketed as a legal substitute for [[MXE]] or [[ketamine]]. The initial batch reportedly smelled like plastic and was suspected of containing impurities. The second batch contained a distinctly different smell of "pokemon cards". | The circumstances surrounding MXiPr's origins are not known. It first appeared on the online research chemical market in late 2020<ref>MXiPr - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=MXiPr</ref> and was specifically marketed as a legal substitute for [[MXE]] or [[ketamine]]. The initial batch reportedly smelled like plastic and was suspected of containing impurities. The second batch contained a distinctly different smell of "pokemon cards". | ||
Its [[ | Its [[subjective effects]] are comparable to that of [[ketamine]] and [[MXE]] and include [[sedation]], [[motor control loss]], [[pain relief]], [[internal hallucinations]], [[conceptual thinking]], [[euphoria]], and [[disconnective effects|dissociation]]. Its subjective effects are described as mostly similar to [[O-PCE]] or MXE, but being more unpredictable and euphoric which makes it further away from ketamine effects-wise. It is presumed to be a strong serotonin reuptake inhibitor like MXE. | ||
Very little data exists about the pharmacological properties, metabolism, and toxicity of MXiPr, and it has a very brief history of human usage. Given the reports of impure batches, it is advised to purify this substance (please see [[MXiPr#Toxicity and harm potential|this section]] and send it into a chemical testing service before use. | Very little data exists about the pharmacological properties, metabolism, and toxicity of MXiPr, and it has a very brief history of human usage. Given the reports of impure batches, it is advised to purify this substance (please see [[MXiPr#Toxicity and harm potential|this section]] and send it into a chemical testing service before use. | ||
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==Chemistry== | ==Chemistry== | ||
MXiPr, or (IUPAC) 2-(3-Methoxyphenyl)-2-[(propan-2-yl)amino]cyclohexan-1-one, is classed as an [[arylcyclohexylamine]] drug.<ref> | MXiPr, or (IUPAC) 2-(3-Methoxyphenyl)-2-[(propan-2-yl)amino]cyclohexan-1-one, is classed as an [[arylcyclohexylamine]] drug.<ref>{{Citation | title=Explore MXiP PiHKAL · info | url=https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14059}}</ref> It posesses an isopropyl group on the nitrogen atom of the molecule as well as a doubled-bonded oxygen atom at the 2' position of the cyclohexyl ring and a methoxy group on the 3 position of the phenyl ring, both of which it shares with [[MXE]]. | ||
==Pharmacology== | ==Pharmacology== | ||
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==Subjective effects== | ==Subjective effects== | ||
{{EffectStub}} | {{EffectStub}} | ||
Early anecdotal reports suggest that MXiPr exhibits two plateaus: The first plateau occurs at doses around 5-20 mg and produces a two hour long experience resembling nitrous oxide, the second plateau occurs at doses around 20-40+ mg giving an experience similar to a [[hole]], but generally considered chaotic, with a remarkably warmer or "dreamier" afterglow which can also become very euphoric. Some researchers urge caution when experimenting with higher doses. There are reports of body load occurring for up to 2 days after a small dose and seizures at very high dosages.<ref>https://www.reddit.com/r/researchchemicals/comments/la97rf/mxipr_consistently_gives_seizures_at_higher/</ref> | Early anecdotal reports suggest that MXiPr exhibits two plateaus: The first plateau occurs at doses around 5-20 mg and produces a two hour long experience resembling nitrous oxide, the second plateau occurs at doses around 20-40+ mg giving an experience similar to a [[Visual_disconnection#Holes.2C_spaces_and_voids|hole]], but generally considered chaotic, with a remarkably warmer or "dreamier" afterglow which can also become very euphoric. Some researchers urge caution when experimenting with higher doses. There are reports of body load occurring for up to 2 days after a small dose and seizures at very high dosages.<ref name="earlygreygreen2021">{{Citation | vauthors=((earlgreygreen)) | year=2021 | title=MXiPR consistently gives seizures at higher dosages administered IM | url=https://www.reddit.com/r/researchchemicals/comments/la97rf/mxipr_consistently_gives_seizures_at_higher/}}</ref> | ||
MXiPr shares similar properties to that of [[MXE]] and [[O-PCE]] but there have been some anecdotal reports that suggest that this may have a potentially higher risk of inducing [[wikipedia:Rhabdomyolysis| Rhabdomyolysis (Wikipedia)]]{{citation needed}} | MXiPr shares similar properties to that of [[MXE]] and [[O-PCE]] but there have been some anecdotal reports that suggest that this may have a potentially higher risk of inducing [[wikipedia:Rhabdomyolysis| Rhabdomyolysis (Wikipedia)]],{{citation needed}} seizures, and amnesia. It is possible that these effects may be avoided by practicing harm reduction via keeping dosages low, infrequent usage, and avoiding combinations. | ||
{{Preamble/SubjectiveEffects}} | {{Preamble/SubjectiveEffects}} | ||
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*'''[[Effect::Nausea]]''' - High dose MXiPr experience can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses. | *'''[[Effect::Nausea]]''' - High dose MXiPr experience can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses. | ||
*'''[[Effect::Optical sliding]]''' | *'''[[Effect::Optical sliding]]''' | ||
*'''[[Effect::Orgasm suppression]]''' & | *'''[[Effect::Orgasm suppression]]''' & '''[[Effect::Orgasm enhancement]]''' - Orgasm enhancement can sometimes also be present, even at higher doses, although this effect is not reliable. | ||
*'''[[Effect::Abnormal heartbeat]]''' | *'''[[Effect::Abnormal heartbeat]]''' | ||
*'''[[Effect::Increased blood pressure]]'''{{citation needed}} - This effect is typically present at the higher doses.{{citation needed}} | *'''[[Effect::Increased blood pressure]]'''{{citation needed}} - This effect is typically present at the higher doses.{{citation needed}} | ||
*'''[[Effect::Increased heart rate]]'''{{citation needed}} - This effect has been reported as being more pronounced than other dissociatives, such as [[DCK]] or [[diphenidine]]. | *'''[[Effect::Increased heart rate]]'''{{citation needed}} - This effect has been reported as being more pronounced than other dissociatives, such as [[DCK]] or [[diphenidine]]. | ||
*'''[[Effect::Increased perspiration]]''' | *'''[[Effect::Increased perspiration]]''' | ||
*'''[[Effect::Seizure]]'''<ref | *'''[[Effect::Seizure]]'''<ref name="earlygreygreen2021"/> - The extent to which this effect can be produced is unknown, but it appears the likelihood of this is more pronounced than other dissociatives, and can probably be avoided by keeping dosage within reasonable levels. The likelihood is also probably increased in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued or undernourished. | ||
}} | }} | ||
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{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}} | {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}} | ||
The toxicity and long-term health effects of recreational MXiPr use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dosage is unknown]]. This is because MXiPr has very little history of human usage. | The toxicity and long-term health effects of recreational MXiPr use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dosage is unknown]]. This is because MXiPr has very little history of human usage. | ||
MXiPr has anecdotally been reported to produce seizures at very high dosages.<ref name="earlygreygreen2021"/> | |||
If one suspects that it may be impure and are still keen on taking this substance, | If one suspects that it may be impure and are still keen on taking this substance, using an oral [[route of administration]] may process the impurities though first-pass metabolism. | ||
It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance. | It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance. | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/MXiPr MXiPr (Wikipedia)] | *[https://en.wikipedia.org/wiki/MXiPr MXiPr (Wikipedia)] | ||
*[https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14059 MXiPr (Isomerdesign)] | |||
===Discussion=== | ===Discussion=== | ||