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MXiPr: Difference between revisions
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{{SummarySheet}} | {{SummarySheet}} | ||
{{SubstanceBox/MXiPr}} | {{SubstanceBox/MXiPr}} | ||
'''3-MeO-2′-Oxo-PCiPr''' (also known as '''MXiPr''') is a novel [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class. It is a structural analog of [[MXE]]. The mechanism of action is not known, but it is likely an NMDA [[receptor]] [[antagonist]], producing [[dissociative]] and [[euphoric]] effects. | |||
The circumstances surrounding MXiPr's origins are not known. It first appeared on the online research chemical market in late 2020<ref>MXiPr - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=MXiPr</ref> and was specifically marketed as a legal substitute for [[MXE]] or [[ketamine]]. The initial batch reportedly smelled like plastic and was suspected of containing impurities. | The circumstances surrounding MXiPr's origins are not known. It first appeared on the online research chemical market in late 2020<ref>MXiPr - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=MXiPr</ref> and was specifically marketed as a legal substitute for [[MXE]] or [[ketamine]]. The initial batch reportedly smelled like plastic and was suspected of containing impurities. The second batch contained a distinctly different smell of "pokemon cards". | ||
[[ | Its [[subjective effects]] are comparable to that of [[ketamine]] and [[MXE]] and include [[sedation]], [[motor control loss]], [[pain relief]], [[internal hallucinations]], [[conceptual thinking]], [[euphoria]], and [[disconnective effects|dissociation]]. Its subjective effects are described as mostly similar to [[O-PCE]] or MXE, but being more unpredictable and euphoric which makes it further away from ketamine effects-wise. It is presumed to be a strong serotonin reuptake inhibitor like MXE. | ||
Very little data exists about the pharmacological properties, metabolism, and toxicity of MXiPr, and it has a very brief history of human usage. Given the reports of impure batches, it is advised to purify this substance (please see [[MXiPr#Toxicity and harm potential|this section]] and send it into a chemical testing service before use. | Very little data exists about the pharmacological properties, metabolism, and toxicity of MXiPr, and it has a very brief history of human usage. Given the reports of impure batches, it is advised to purify this substance (please see [[MXiPr#Toxicity and harm potential|this section]] and send it into a chemical testing service before use. | ||
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==Chemistry== | ==Chemistry== | ||
MXiPr, or (IUPAC) 2-(3-Methoxyphenyl)-2-[(propan-2-yl)amino]cyclohexan-1-one, is classed as an [[arylcyclohexylamine]] drug.<ref>{{Citation | title=Explore MXiP PiHKAL · info | url=https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14059}}</ref> It posesses an isopropyl group on the nitrogen atom of the molecule as well as a doubled-bonded oxygen atom at the 2' position of the cyclohexyl ring and a methoxy group on the 3 position of the phenyl ring, both of which it shares with [[MXE]]. | |||
MXiPr, or (IUPAC) 2-(3-Methoxyphenyl)-2-[(propan-2-yl)amino]cyclohexan-1-one, is classed as an [[arylcyclohexylamine]] drug. | |||
==Pharmacology== | ==Pharmacology== | ||
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Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “[http://en.wikipedia.org/wiki/K-hole k-hole].” | Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “[http://en.wikipedia.org/wiki/K-hole k-hole].” | ||
Given its structural similarity to [[MXE]] and according to anecdotal reports, this substance may be a strong serotonin reuptake inhibitor (SRI). | Given its structural similarity to [[MXE]] and according to anecdotal reports, this substance may be a strong serotonin reuptake inhibitor (SRI). One should avoid combining MXiPr with other drugs that act on serotonin. | ||
==Subjective effects== | ==Subjective effects== | ||
{{EffectStub}} | {{EffectStub}} | ||
Early anecdotal reports suggest that MXiPr exhibits two plateaus: The first plateau occurs at doses around 5-20 mg and produces a two hour long experience resembling nitrous oxide, the second plateau occurs at doses around 20-40+ mg giving an experience similar to a [[hole]], with a remarkably warmer or "dreamier" afterglow. | Early anecdotal reports suggest that MXiPr exhibits two plateaus: The first plateau occurs at doses around 5-20 mg and produces a two hour long experience resembling nitrous oxide, the second plateau occurs at doses around 20-40+ mg giving an experience similar to a [[Visual_disconnection#Holes.2C_spaces_and_voids|hole]], but generally considered chaotic, with a remarkably warmer or "dreamier" afterglow which can also become very euphoric. Some researchers urge caution when experimenting with higher doses. There are reports of body load occurring for up to 2 days after a small dose and seizures at very high dosages.<ref name="earlygreygreen2021">{{Citation | vauthors=((earlgreygreen)) | year=2021 | title=MXiPR consistently gives seizures at higher dosages administered IM | url=https://www.reddit.com/r/researchchemicals/comments/la97rf/mxipr_consistently_gives_seizures_at_higher/}}</ref> | ||
MXiPr | MXiPr shares similar properties to that of [[MXE]] and [[O-PCE]] but there have been some anecdotal reports that suggest that this may have a potentially higher risk of inducing [[wikipedia:Rhabdomyolysis| Rhabdomyolysis (Wikipedia)]],{{citation needed}} seizures, and amnesia. It is possible that these effects may be avoided by practicing harm reduction via keeping dosages low, infrequent usage, and avoiding combinations. | ||
{{Preamble/SubjectiveEffects}} | {{Preamble/SubjectiveEffects}} | ||
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|{{effects/physical| | |{{effects/physical| | ||
*'''[[Effect::Sedation]]''' | *'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' - At low to moderate dosages, MXiPr is primarily stimulating while at higher dosages the experience turns sedating. | ||
*'''[[Effect::Spontaneous bodily sensations]]''' - The MXiPr "body high" can be described as a sharp, pleasurable tingling sensation which is location specific to the hands, feet, and head. | *'''[[Effect::Spontaneous bodily sensations]]''' - The MXiPr "body high" can be described as a sharp, pleasurable tingling sensation which is location specific to the hands, feet, and head. | ||
*'''[[Effect::Perception of bodily lightness]]''' - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating | *'''[[Effect::Perception of bodily lightness]]''' - This creates the sensation that the body is floating and has become entirely weightless. This effect is very prevalent with MXiPr and strangely stimulating. It encourages physical activities at low to moderate doses by making the body feel light and effortless to move. | ||
*'''[[Effect::Motor control loss]]''' - A loss of gross and fine motor control alongside balance and coordination is prevalent on MXiPr and becomes especially strong at higher doses. This means that one should be sitting down before the onset (unless experienced) in the case of falling over and injuring oneself. | *'''[[Effect::Motor control loss]]''' - A loss of gross and fine motor control alongside balance and coordination is prevalent on MXiPr and becomes especially strong at higher doses. This means that one should be sitting down before the onset (unless experienced) in the case of falling over and injuring oneself. | ||
*'''[[Effect::Spatial disorientation]] | *'''[[Effect::Spatial disorientation]] | ||
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*'''[[Effect::Nausea]]''' - High dose MXiPr experience can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses. | *'''[[Effect::Nausea]]''' - High dose MXiPr experience can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses. | ||
*'''[[Effect::Optical sliding]]''' | *'''[[Effect::Optical sliding]]''' | ||
*'''[[Effect::Orgasm suppression]]''' - Orgasm enhancement can also be present, even at higher doses. | *'''[[Effect::Orgasm suppression]]''' & '''[[Effect::Orgasm enhancement]]''' - Orgasm enhancement can sometimes also be present, even at higher doses, although this effect is not reliable. | ||
*'''[[Effect::Abnormal heartbeat]]''' | *'''[[Effect::Abnormal heartbeat]]''' | ||
*'''[[Effect::Increased blood pressure]]'''{{citation needed}} - This effect is typically present at the higher doses.{{citation needed}} | *'''[[Effect::Increased blood pressure]]'''{{citation needed}} - This effect is typically present at the higher doses.{{citation needed}} | ||
*'''[[Effect::Increased heart rate]]'''{{citation needed}} - This effect has been reported as being more pronounced than other dissociatives, such as [[DCK]] or [[diphenidine]]. | *'''[[Effect::Increased heart rate]]'''{{citation needed}} - This effect has been reported as being more pronounced than other dissociatives, such as [[DCK]] or [[diphenidine]]. | ||
*'''[[Effect::Increased perspiration]]''' | *'''[[Effect::Increased perspiration]]''' | ||
*'''[[Effect::Seizure]]''' - The extent to which this effect can be produced is unknown, but it appears the likelihood of this is more pronounced than other dissociatives, and can probably be avoided by keeping dosage within reasonable levels. The likelihood is also probably increased in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued or undernourished. | *'''[[Effect::Seizure]]'''<ref name="earlygreygreen2021"/> - The extent to which this effect can be produced is unknown, but it appears the likelihood of this is more pronounced than other dissociatives, and can probably be avoided by keeping dosage within reasonable levels. The likelihood is also probably increased in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued or undernourished. | ||
}} | }} | ||
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====Hallucinatory states==== | ====Hallucinatory states==== | ||
*'''[[Effect::Internal hallucination]]''' (''[[effect::settings, sceneries, and landscapes]]'' | *'''[[Effect::Internal hallucination]]''' (''[[effect::settings, sceneries, and landscapes]]'', ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'') | ||
*'''[[Effect::Machinescapes]]''' | *'''[[Effect::Machinescapes]]''' | ||
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'') - This effect can be comprehensively described through its [[Internal_hallucinations#Variations|variations]] as delirious in believability, fixed in style, equal in new experiences and memory replays in content, autonomous in controllability and solid in style. | *'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'') - This effect can be comprehensively described through its [[Internal_hallucinations#Variations|variations]] as delirious in believability, fixed in style, equal in new experiences and memory replays in content, autonomous in controllability and solid in style. | ||
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*'''[[Effect::Anxiety suppression]]''' | *'''[[Effect::Anxiety suppression]]''' | ||
*'''[[Effect::Disinhibition]]''' | *'''[[Effect::Disinhibition]]''' | ||
*'''[[Effect::Cognitive euphoria]]''' | *'''[[Effect::Cognitive euphoria]]''' - The euphoria of this substance is reported to be stronger than that of other dissociatives like [[O-PCE]] but weaker than that of [[MXE]]. | ||
*'''[[Effect::Conceptual thinking]]''' | *'''[[Effect::Conceptual thinking]]''' | ||
*'''[[Effect::Creativity enhancement]]''' | *'''[[Effect::Creativity enhancement]]''' | ||
*'''[[Effect::Déjà vu]]''' | *'''[[Effect::Déjà vu]]''' | ||
*'''[[Effect::Mania]]''' - Some users have reported mania on this substance. The frequency of which is undetermined. It is strongly recommended to use harm-reduction practices and not use this substance in high amounts or frequently. Most likely, it is more common than most [[arylcyclohexylamines]] but less common in occurrence compared to PCP and 3-MeO-PCP. | *'''[[Effect::Mania]]''' - Some users have reported mania on this substance. The frequency of which is undetermined. It is strongly recommended to use harm-reduction practices and not use this substance in high amounts or frequently. Most likely, it is more common than most [[arylcyclohexylamines]] but less common in occurrence compared to [[PCP]] and [[3-MeO-PCP]]. | ||
*'''[[Effect::Depersonalization]]''' & '''[[Effect::Derealization]]''' | *'''[[Effect::Depersonalization]]''' & '''[[Effect::Derealization]]''' | ||
*'''[[Effect::Delusion]]''' - Most likely, | *'''[[Effect::Delusion]]''' - Most likely, this effect is more common with MXiPr than with most other [[arylcyclohexylamines]] but less common in occurrence compared to substances like 3-MeO-PCP. | ||
*'''[[Effect::Dream potentiation]]''' | *'''[[Effect::Dream potentiation]]''' | ||
*'''[[Effect::Memory suppression]]''' | *'''[[Effect::Memory suppression]]''' | ||
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{{effects/auditory| | {{effects/auditory| | ||
The auditory effects of MXiPr have been described as more pronounced than other hallucinogens. These effects include: | The auditory effects of MXiPr have been described as more pronounced than other [[hallucinogens]]. These effects include: | ||
*'''[[Effect::Auditory distortion|Distortions]]''' - These distortions are very powerful and loud enough in their volume to make the original sound completely unrecognizable. They include phasers, white noise, high pitch tones and notes, flanging, changes in pitch, echo effects, and stuttering. In particular, the frequency of the stuttering is proportionally related to the intensity of the effects, especially ego death which occurs when the stuttering becomes continuous. | *'''[[Effect::Auditory distortion|Distortions]]''' - These distortions are very powerful and loud enough in their volume to make the original sound completely unrecognizable. They include phasers, white noise, high pitch tones and notes, flanging, changes in pitch, echo effects, and stuttering. In particular, the frequency of the stuttering is proportionally related to the intensity of the effects, especially ego death which occurs when the stuttering becomes continuous. | ||
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Additional experience reports can be found here: | Additional experience reports can be found here: | ||
*[https://www.erowid.org/experiences/subs/exp_MXiPr.shtml Erowid Experience Vaults: MXiPr] | *[https://www.erowid.org/experiences/subs/exp_MXiPr.shtml Erowid Experience Vaults: MXiPr] | ||
*[https://www.reddit.com/r/researchchemicals/comments/la97rf/mxipr_consistently_gives_seizures_at_higher/ Reddit: MXiPr consistently gives seizures at higher dosages administered IM] | *[https://www.reddit.com/r/researchchemicals/comments/la97rf/mxipr_consistently_gives_seizures_at_higher/ Reddit: MXiPr consistently gives seizures at higher dosages administered IM] | ||
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{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}} | {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}} | ||
The toxicity and long-term health effects of recreational MXiPr use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dosage is unknown]]. This is because MXiPr has very little history of human usage. | The toxicity and long-term health effects of recreational MXiPr use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dosage is unknown]]. This is because MXiPr has very little history of human usage. | ||
MXiPr has anecdotally been reported to produce seizures at very high dosages.<ref name="earlygreygreen2021"/> | |||
If one suspects that it may be impure and are still keen on taking this substance, | If one suspects that it may be impure and are still keen on taking this substance, using an oral [[route of administration]] may process the impurities though first-pass metabolism. | ||
It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance. | It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance. | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/MXiPr MXiPr (Wikipedia)] | *[https://en.wikipedia.org/wiki/MXiPr MXiPr (Wikipedia)] | ||
*[https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14059 MXiPr (Isomerdesign)] | |||
===Discussion=== | ===Discussion=== | ||