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Talk:Phenylephrine: Difference between revisions

← Older edit
>Xbdab
Added more toxicity information
>SquaricAcid
m phenylephrine has no psychedelic action and is definitely not a tryptamine (fixed this)
 
(15 intermediate revisions by 2 users not shown)
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{{headerpanel|{{Approval}}}}
{{headerpanel|{{Approval}}}}
{{SummarySheet}}
{{SummarySheet}}
{{SubstanceBox/Example}}
{{SubstanceBox
 
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    <!-- Nomenclature -->
    |NameCommon=Phenylephrine
    |NameSubstitution=Neo-synephrine, m-Synephrine, β-HO-N-Me-3-HPEA
    |NameSystematic=3-[1-Hydroxy-2-(methylamino)ethyl]phenol
 
    <!-- Class Membership -->
    |EffectClass=[[psychoactive class::Stimulant]]
    |ChemicalClass=[[chemical class::Phenethylamine]]
 
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    |OralROA_Strong=[[Oral min strong dose::x]] - [[Oral max strong dose::59]] mg
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'''Phenylephrine''' is used as a decongestant sold as an oral medicine or as a nasal spray. It is a common ingredient in over-the-counter decongestants in the United States.
'''Phenylephrine''' is used as a decongestant sold as an oral medicine or as a nasal spray. It is a common ingredient in over-the-counter decongestants in the United States.
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Phenylephrine was patented in 1927 and came into medical use in 1938. It is available as a generic medication
Phenylephrine was patented in 1927 and came into medical use in 1938. It is available as a generic medication


==Chemistry==
{{chemistry}}
==Pharmacology==
==Pharmacology==
{{pharmacology}}
{{pharmacology}}
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==Subjective effects==
==Subjective effects==
{{EffectStub}}
{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
{{effects/base
{{effects/base
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|{{effects/physical|
|{{effects/physical|


*'''[[Effect::Pupil dilation]]'''  
*'''[[Nasal decongestion]]'''
*'''[[Effect::Pupil dilation]]''' - Most common when used in eye drops
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Abnormal heartbeat]]'''
*'''[[Effect::Abnormal heartbeat]]''' - This effect is most prevalent in high doses
*'''[[Effect::Headache]]'''
*'''[[Effect::Headache]]''' - This effect is most prevalent in high doses
*'''[[Effect::Skin flushing]]'''
*'''[[Effect::Skin flushing]]'''
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Dizziness]]'''
*'''[[Effect::Dizziness]]''' - This effect is most prevalent in high doses
*'''[[Effect::Nausea]]'''  
*'''[[Effect::Nausea]]'''  
}}
}}
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*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Anxiety]]'''
*'''[[Effect::Anxiety]]''' - This effect is most prevalent in high doses
*'''[[Effect::Insomnia]]''' - This effect is most prevalent in high doses
}}
}}
}}
}}
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===Dangerous interactions===
===Dangerous interactions===
{{DangerousInteractions}}
{{DangerousInteractions}}
{{DangerousInteractions/Intro}}


The increase in blood pressure effect of phenylephrine may be increased by drugs such as '''monoamine oxidase inhibitors''', '''tricyclic antidepressants''', and '''hydrocortisone'''. Patients taking these medications may need a lower dose of phenylephrine to achieve a similar increase in blood pressure.
The increase in blood pressure effect of phenylephrine may be increased by drugs such as '''monoamine oxidase inhibitors''', '''tricyclic antidepressants''', and '''hydrocortisone'''. Patients taking these medications may need a lower dose of phenylephrine to achieve a similar increase in blood pressure.
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* [https://en.wikipedia.org/wiki/Phenylephrine Phenylephrine (Wikipedia)]
* [https://en.wikipedia.org/wiki/Phenylephrine Phenylephrine (Wikipedia)]
* [https://www.erowid.org/experiences/subs/exp_Pharms_Phenylephrine.shtml Phenylephrine (Erowid Vault)]
* [https://www.erowid.org/experiences/subs/exp_Pharms_Phenylephrine.shtml Phenylephrine (Erowid Vault)]
* [https://isomerdesign.com/PiHKAL/explore.php?id=6157&name=Phenylephrine Phenylephrine (Isomer Design)]
* [https://www.drugs.com/mtm/phenylephrine.html Phenylephrine (Drugs.com)]
* [https://www.drugs.com/mtm/phenylephrine.html Phenylephrine (Drugs.com)]
* [https://pubchem.ncbi.nlm.nih.gov/compound/6041 Phenylephrine (Pubchem)]  
* [https://pubchem.ncbi.nlm.nih.gov/compound/6041 Phenylephrine (Pubchem)]  
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