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Talk:Phenylephrine: Difference between revisions

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>Xbdab
Updated
>SquaricAcid
m phenylephrine has no psychedelic action and is definitely not a tryptamine (fixed this)
 
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{{headerpanel|{{Approval}}}}
{{headerpanel|{{Approval}}}}
{{SummarySheet}}
{{SummarySheet}}
{{SubstanceBox/Example}}
{{SubstanceBox
 
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    <!-- Nomenclature -->
    |NameCommon=Phenylephrine
    |NameSubstitution=Neo-synephrine, m-Synephrine, β-HO-N-Me-3-HPEA
    |NameSystematic=3-[1-Hydroxy-2-(methylamino)ethyl]phenol
 
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    |EffectClass=[[psychoactive class::Stimulant]]
    |ChemicalClass=[[chemical class::Phenethylamine]]
 
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'''Phenylephrine''' is used as a decongestant sold as an oral medicine or as a nasal spray. It is a common ingredient in over-the-counter decongestants in the United States.
'''Phenylephrine''' is used as a decongestant sold as an oral medicine or as a nasal spray. It is a common ingredient in over-the-counter decongestants in the United States.
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Phenylephrine was patented in 1927 and came into medical use in 1938. It is available as a generic medication
Phenylephrine was patented in 1927 and came into medical use in 1938. It is available as a generic medication


==Chemistry==
{{chemistry}}
==Pharmacology==
==Pharmacology==
{{pharmacology}}
{{pharmacology}}
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==Subjective effects==
==Subjective effects==
{{EffectStub}}
{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
{{effects/base
{{effects/base
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|{{effects/physical|
|{{effects/physical|


*'''[[Effect::Pupil dilation]]'''  
*'''[[Nasal decongestion]]'''
*'''[[Effect::Pupil dilation]]''' - Most common when used in eye drops
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Abnormal heartbeat]]'''
*'''[[Effect::Abnormal heartbeat]]''' - This effect is most prevalent in high doses
*'''[[Effect::Headache]]'''
*'''[[Effect::Headache]]''' - This effect is most prevalent in high doses
*'''[[Effect::Skin flushing]]'''
*'''[[Effect::Skin flushing]]'''
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Dizziness]]'''
*'''[[Effect::Dizziness]]''' - This effect is most prevalent in high doses
*'''[[Effect::Nausea]]'''  
*'''[[Effect::Nausea]]'''  
}}
}}
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*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Anxiety]]'''
*'''[[Effect::Anxiety]]''' - This effect is most prevalent in high doses
*'''[[Effect::Insomnia]]''' - This effect is most prevalent in high doses
}}
}}
}}
}}
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It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance.
It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance.
===Lethal dosage===
===Lethal dosage===
The median lethal dose of phenylephrine taken orally at which 50% of participants die ([[LD50|LD<sub>50</sub>]]) for rats is 350mg/kg
===Tolerance and addiction potential===
===Tolerance and addiction potential===
Non-addictive with a low potential of abuse
===Dangerous interactions===
===Dangerous interactions===
{{DangerousInteractions}}
{{DangerousInteractions}}
{{DangerousInteractions/Intro}}


The increase in blood pressure effect of phenylephrine may be increased by drugs such as '''monoamine oxidase inhibitors''', '''tricyclic antidepressants''', and '''hydrocortisone'''. Patients taking these medications may need a lower dose of phenylephrine to achieve a similar increase in blood pressure.
The increase in blood pressure effect of phenylephrine may be increased by drugs such as '''monoamine oxidase inhibitors''', '''tricyclic antidepressants''', and '''hydrocortisone'''. Patients taking these medications may need a lower dose of phenylephrine to achieve a similar increase in blood pressure.
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* [https://en.wikipedia.org/wiki/Phenylephrine Phenylephrine (Wikipedia)]
* [https://en.wikipedia.org/wiki/Phenylephrine Phenylephrine (Wikipedia)]
* [https://www.erowid.org/experiences/subs/exp_Pharms_Phenylephrine.shtml Phenylephrine (Erowid Vault)]
* [https://www.erowid.org/experiences/subs/exp_Pharms_Phenylephrine.shtml Phenylephrine (Erowid Vault)]
* [https://www.drugs.com/mtm/phenylephrine.html Phenylephrine (drugs.com)]  
* [https://isomerdesign.com/PiHKAL/explore.php?id=6157&name=Phenylephrine Phenylephrine (Isomer Design)]
* [https://www.drugs.com/mtm/phenylephrine.html Phenylephrine (Drugs.com)]
* [https://pubchem.ncbi.nlm.nih.gov/compound/6041 Phenylephrine (Pubchem)]  


==References==
==References==
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