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Talk:5-MeO-aMT: Difference between revisions
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{{SummarySheet}} | {{SummarySheet}} | ||
{{SubstanceBox/5-MeO-aMT}} | {{SubstanceBox/5-MeO-aMT}} | ||
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==Chemistry== | ==Chemistry== | ||
5-MeO-aMT, or 5-methoxy-α-methyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 5-MeO-aMT is substituted at the alpha carbon R<sub>α</sub> of its tryptamine backbone with a methyl group. | 5-MeO-aMT, or 5-methoxy-α-methyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. Like [[aMT]], 5-MeO-aMT is substituted at the alpha carbon R<sub>α</sub> of its tryptamine backbone with a methyl group, but differs from aMT by a methoxy group added to the R<sub>5</sub> position. | ||
A comparison of the R- and S-isomers found that the S-isomer is "clearly three or four times more potent" than the R-isomer. The S-isomer is the d- or dextrorotary one and has been noted to possess the absolute configuration of the active member of the isomer pairs of [[amphetamine]], [[methamphetamine]], and [[MDMA]].<ref name="tihkalweb" /> | A comparison of the R- and S-isomers found that the S-isomer is "clearly three or four times more potent" than the R-isomer. The S-isomer is the d- or dextrorotary one and has been noted to possess the absolute configuration of the active member of the isomer pairs of [[amphetamine]], [[methamphetamine]], and [[MDMA]].<ref name="tihkalweb" /> | ||
==Pharmacology== | ==Pharmacology== | ||
{{pharmacology}} | |||
{{Further|Serotonergic psychedelic}} | {{Further|Serotonergic psychedelic}} | ||
5-MeO-aMT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. | 5-MeO-aMT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive. | ||
5-MeO-AMT also inhibits [[monoamines]] ([[dopamine]], [[serotonin]] and [[norepinephrine]]) reuptake and stimulates their release.<ref>The Effects of Non-Medically Used Psychoactive Drugs on Monoamine Neurotransmission in Rat Brain | https://pubmed.ncbi.nlm.nih.gov/17223101</ref> | |||
==Subjective effects== | ==Subjective effects== | ||
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*'''[[Effect::Nausea]]''' - Given the physical discomfort experienced on this substance, moderate to extreme nausea is almost consistently reported when consumed at any dosage. This either passes once the user has vomited or gradually fades by itself as the peak sets in. | *'''[[Effect::Nausea]]''' - Given the physical discomfort experienced on this substance, moderate to extreme nausea is almost consistently reported when consumed at any dosage. This either passes once the user has vomited or gradually fades by itself as the peak sets in. | ||
*'''[[Effect::Pupil dilation]]''' | *'''[[Effect::Pupil dilation]]''' | ||
}} | }} | ||
{{effects/visual| | {{effects/visual| | ||
The visual effects of 5-MeO-aMT are mostly present only when large doses have been consumed and are proportionally mild in comparison to the intensity of its accompanying cognitive and physical effects when compared to substances such as [[LSD]] and [[psilocin]]. | The visual effects of 5-MeO-aMT are mostly present only when large doses have been consumed and are proportionally mild in comparison to the intensity of its accompanying cognitive and physical effects when compared to substances such as [[LSD]] and [[psilocin]]. | ||
====Enhancements==== | ====Enhancements==== | ||
*'''[[Effect::Visual acuity enhancement|Acuity enhancement]]''' | *'''[[Effect::Visual acuity enhancement|Acuity enhancement]]''' | ||
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*'''[[Effect::Scenery slicing]]''' | *'''[[Effect::Scenery slicing]]''' | ||
*'''[[Effect::Tracers]]''' | *'''[[Effect::Tracers]]''' | ||
====Hallucinatory states==== | ====Hallucinatory states==== | ||
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{{#ask:[[Category:Experience]][[Category:5-MeO-aMT]]|format=ul|Columns=1}} | {{#ask:[[Category:Experience]][[Category:5-MeO-aMT]]|format=ul|Columns=1}} | ||
Additional experience reports can be found here: | Additional experience reports can be found here: | ||
* [https://www.erowid.org/experiences/subs/ | *[https://www.erowid.org/experiences/subs/exp_5MeOAMT.shtml Erowid Experience Vaults: 5-MeO-aMT] | ||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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===Dangerous interactions=== | ===Dangerous interactions=== | ||
{{DangerousInteractions/Intro}} | |||
{{DangerousInteractions/Psychedelics}} | |||
Deaths from 5-MeO-aMT are rare but as a powerful [[monoamine]] [[reuptake inhibitor]] (MRI), injury could occur when excessive doses are taken or when it is taken with substances such as [[MAOIs]], [[RIMA]]s, [[stimulant]]s and any substance which act as a [[releasing agent]] or [[reuptake inhibitor]] of [[neurotransmitters]] such as [[serotonin]] and [[dopamine]].<ref>Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity | http://bja.oxfordjournals.org/content/95/4/434</ref> | Deaths from 5-MeO-aMT are rare but as a powerful [[monoamine]] [[reuptake inhibitor]] (MRI), injury could occur when excessive doses are taken or when it is taken with substances such as [[MAOIs]], [[RIMA]]s, [[stimulant]]s and any substance which act as a [[releasing agent]] or [[reuptake inhibitor]] of [[neurotransmitters]] such as [[serotonin]] and [[dopamine]].<ref>Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity | http://bja.oxfordjournals.org/content/95/4/434</ref> | ||
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== | ==Legal status== | ||
{{legalStub}} | {{legalStub}} | ||
*'''United States''': 5-MeO-AMT is unscheduled in the United States. It is possible that it could be considered an analog (of AMT), in which case, sales for human consumption or possession with the intent to ingest could be prosecuted under the Federal Analogue Act. The DEA and the US Department of Justice consider 5-MeO-AMT a controlled substance analogue, making it a Schedule I substance when intended for human consumption.<ref>{{Citation | year=2022 | title=5-MeO-AMT Fast Facts | publisher=US DOJ | url=https://www.justice.gov/archive/ndic/pubs9/9576/index.htm}}</ref> | |||
==See also== | ==See also== | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/5-MeO-aMT 5-MeO-aMT (Wikipedia)] | |||
*[https://www.erowid.org/chemicals/5meo_amt/ 5-MeO-aMT (Erowid Vault)] | |||
*[https://isomerdesign.com/PiHKAL/explore.php?id=5005 5-MeO-aMT (TiHKAL / Isomer Design)] | |||
===Discussion=== | |||
*[https://www.bluelight.org/xf/threads/61754 The Big & Dandy 5-MeO-AMT Thread (Bluelight)] | |||
==References== | ==References== | ||
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[[Category:Psychedelic]] | [[Category:Psychedelic]] | ||
[[Category:Entactogen]] | [[Category:Entactogen]] | ||
[[Category:Stimulant]] | |||
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[[Category:Proofread]] | |||
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