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Talk:Etazene: Difference between revisions
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==History and culture== | ==History and culture== | ||
Very little is known about | Very little is known about etazene's origin, it first came to the public eye in 2020, when it was first seized by law enforcement. People speculate it is a etonitazene like Research chemical, with similar effects but a much lower LD50. | ||
Etazene is an analgesic drug, first reported in 2020, that has been shown to have approximately one thousand to one thousand five hundred times the potency of morphine in animal models, but only sixty to seventy times the potency in humans. | Etazene is an analgesic drug, first reported in 2020, that has been shown to have approximately one thousand to one thousand five hundred times the potency of morphine in animal models, but only sixty to seventy times the potency in humans. | ||
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==Chemistry== | ==Chemistry== | ||
Etazene is a synthetic opioid in the benzimidazole family. The structures of opioids share many similarities. Whereas opioids like | Etazene is a synthetic opioid in the benzimidazole family. The structures of opioids share many similarities. Whereas opioids like hydrocodone, oxycodone, and hydromorphone are synthesized by simple modifications of morphine, etazene and its relatives are synthesized using the benzimidazole chemical structure. | ||
==Subjective effects== | ==Subjective effects== | ||
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===Dependence and tolerance potential=== | ===Dependence and tolerance potential=== | ||
As with other [[opioids]], the chronic use of | As with other [[opioids]], the chronic use of etazene can be considered [[Addiction potential::highly addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[Opioids#Discontinuation|withdrawal symptoms]] may occur if a person suddenly stops their usage. | ||
Tolerance to many of the effects of Etazene [[Time to full tolerance::develops with prolonged and repeated use]]. The rate at which this occurs develops at different rates for different effects, with tolerance to the constipation-inducing effects developing particularly slowly for instance. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Etazene presents cross-tolerance with [[Cross-tolerance::all other [[opioids]]]], meaning that after the consumption of Etazene all [[opioid]]s will have a reduced effect. | Tolerance to many of the effects of Etazene [[Time to full tolerance::develops with prolonged and repeated use]]. The rate at which this occurs develops at different rates for different effects, with tolerance to the constipation-inducing effects developing particularly slowly for instance. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Etazene presents cross-tolerance with [[Cross-tolerance::all other [[opioids]]]], meaning that after the consumption of Etazene all [[opioid]]s will have a reduced effect. | ||
==Legal status== | |||
{{LegalStub}} | |||
'''Turkey:''' Etazene is a classed as drug and is illegal to possess, produce, supply, or import.<ref>https://resmigazete.gov.tr/eskiler/2020/10/20201007-8.pdf</ref> | |||
==External links== | ==External links== | ||
(List along order below) | (List along order below) | ||
* [https://en.wikipedia.org/wiki/Etonitazene (Wikipedia)] | |||
*[https://en.wikipedia.org/wiki/Etonitazene (Wikipedia)] | |||
<!-- ==Literature== --> | <!-- ==Literature== --> | ||
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==External links== | ==External links== | ||
(List along order below) | (List along order below) | ||
*[https://en.wikipedia.org/wiki/Etonitazene (Wikipedia)] | |||
[[Category:Psychoactive substance]][[Category:Proofread]][[Category:Approval]] | [[Category:Psychoactive substance]] | ||
[[Category:Proofread]] | |||
[[Category:Approval]] | |||