Talk:Etazene: Difference between revisions

(38 intermediate revisions by 7 users not shown)

Line 2:

{{decree|type=notice|message=This article is in the 'Talk' namespace because it is an unfinished draft. This section is used to host drafts for unpublished articles as well as discussions for published ones. If you'd like to use this area to discuss this draft, please do so in the 'Discussion' section at the very bottom of the page. This notice will be removed once this draft has been approved for publication by an administrator.}}

{{headerpanel|{{ETAZENE}}}}

'''Etodesnitazene''' (Desnitroetonitazene, Etazen, '''Etazene''', Etazone) is a benzimidazole derived [[opioid]] [[analgesic]] drug, which was originally developed in the late 1950s alongside [[etonitazene]] and a range of related derivatives.<ref>Vandeputte M, et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of nitazene new synthetic opioids. Authorea. November 12, 2020. doi:10.22541/au.160520665.59016513/v1</ref> It is many times less potent than [[etonitazene]] itself, but still 70x more potent than [[morphine]] in animal studies. Corresponding analogues where the N,N-diethyl group is replaced by [[piperidine]] or [[pyrrolidine]] rings also retain significant activity (10x and 20x morphine respectively).<ref>Hunger A, Kebrle J, Rossi A, Hoffmann K (1960). "Benzimidazol‐Derivate und verwandte Heterocyclen. II. Synthese von 1‐Aminoalkyl‐2‐benzyl‐benzimidazolen". Helvetica Chimica Acta (in German). 43 (3): 800–809. doi:10.1002/hlca.19600430323.</ref>

~~For tips on how~~ to ~~properly format~~ a ~~substance article~~, ~~please refer to this document: [[Content Style Guide - Substance]]~~

==History and culture==

Very little is known about etazene's origin, it first came to the public eye in 2020, when it was first seized by law enforcement. People speculate it is a etonitazene like Research chemical, with similar effects but a much lower LD50.

~~==History and culture==~~

Etazene is an analgesic drug, first reported in 2020, that has been shown to have approximately one thousand to one thousand five hundred times the potency of morphine in animal models, but only sixty to seventy times the potency in humans.

Very little is known about etaznenes origin, it first came to the public eye in 2020, when it was first siezed by law enforcement. People speculate it is a etazene like Research chemical, with similar effects but a much lower LD50

~~etazene~~ is an analgesic drug, first reported in 2020, that has been shown to have approximately one thousand to one thousand five hundred times the potency of morphine in animal models, but only sixty to seventy times the potency in humans.

Because it is characterized by a strong dependency potential and a tendency to produce profound respiratory depression, it is not used in humans. It is, however, useful in animal models for addiction studies, particularly those requiring the animals to drink or ingest the agent, because it is not as bitter as opiate salts like morphine sulfate.

==Pharmacology==

~~etazene is a synthetic~~ opioid in ~~the phenylpiperidine family,~~ which ~~includes sufentanil~~, ~~alfentanil~~, ~~remifentanil~~, and ~~carfentanil~~

[[Opioid]]s exert their effects by binding to and activating the [[Opioid#Mu_.28.CE.BC.29|μ-opioid]] [[receptor]]. This occurs because opioids structurally mimic endogenous endorphins which are naturally found within the body and also work upon the μ-opioid receptor set. The way in which opioids structurally mimic these natural endorphins results in their [[physical euphoria|euphoria]], [[pain relief]] and [[anxiolytic]] effects. This is because endorphins are responsible for reducing pain, causing sleepiness, and feelings of pleasure. They can be released in response to pain, strenuous exercise, orgasm, or general excitement.

The structures of opioids share many similarities. Whereas opioids like ~~codeine,~~ hydrocodone, oxycodone, and hydromorphone are synthesized by simple modifications of morphine, etazene and its relatives are synthesized ~~by modifications of meperidine. Meperidine is a fully synthetic opioid, and other members of~~ the ~~phenylpiperidine family like alfentanil and sufentanil are complex versions of this~~ structure. ~~etazene is a weak base that is highly lipid-soluble, protein-bound, and protonated at physiological pH~~

==Chemistry==

Etazene is a synthetic opioid in the benzimidazole family. The structures of opioids share many similarities. Whereas opioids like hydrocodone, oxycodone, and hydromorphone are synthesized by simple modifications of morphine, etazene and its relatives are synthesized using the benzimidazole chemical structure.

==Subjective effects==

~~subjective effects include:~~

~~euphoria~~

~~muscle relaxation~~

~~sedation~~

~~pupil constriction~~

~~mood lift~~

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI),It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses are more likely to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death.

}}

{{effects/base

|{{effects/physical|

The general sensation of methadone can be described as one of euphoria, relaxation, anxiety suppression and pain relief.

*'''[[Effect::Pain relief]]'''

~~You may select physical effects to add below [[~~

*'''[[Effect::Physical euphoria]]''' - This particular substance can be considered as less intense in its physical euphoria when compared with that of [[morphine]] or [[diacetylmorphine]] (heroin), but stronger than that of other synthetic opioids such as [[tramadol]]. The sensation itself can be described as extreme feelings of intense physical comfort, warmth, love and bliss.

~~Sedation - etazene~~ can be described as ~~much more sedating then other opiates. Even at moderate dosages~~, ~~etazene can result in overwhelming feelings of sedation~~ and ~~tiredness that is considerably more sedating than that of heroin and oxycodone~~.

*'''[[Effect::Itchiness]]'''

Pain relief ~~- In comparison to other opiates, etazene can be described as a strong analgesic, providing relief even at non-recreational doses.~~

*'''[[Effect::Respiratory depression]]''' - At low to moderate doses, this effect results in the sensation that the breath is slowed down mildly to moderately, but does not cause noticeable impairment. At high doses and overdoses, opioid-induced respiratory depression can result in a shortness of breath, abnormal breathing patterns, semi-consciousness, or unconsciousness. Severe overdoses can result in a coma or death without immediate medical attention.

Physical euphoria - ~~etazene~~ can be considered as less intense in its physical euphoria when compared with that of morphine or diacetylmorphine (heroin). The sensation itself can be described as ~~strong~~ feelings of intense physical comfort, warmth and bliss ~~which spread throughout the body~~.

*'''[[Effect::Constipation]]'''

Itchiness ~~- Unlike other opioids, etazene presents very little itch response due to little to no amounts of released histamines.~~

*'''[[Effect::Cough suppression]]'''

Respiratory depression - ~~In comparison~~ to ~~other opiates~~, ~~etazene displays~~ this effect ~~at lower doses relative to euphoria then other opiates, and even at low doses~~ results in the sensation that the breath is slowed down mildly to moderately, but does not cause noticeable impairment. At high doses and overdoses, opioid-induced respiratory depression can result in a shortness of breath, abnormal breathing patterns, semi-consciousness, or unconsciousness. Severe overdoses can result in a coma or death without immediate medical attention.

*'''[[Effect::Difficulty urinating]]'''

Constipation

*'''[[Effect::Nausea]]'''

Cough suppression

*'''[[Effect::Sedation]]'''

~~Decreased libido~~

*'''[[Effect::Pupil constriction]]'''

Difficulty urinating

*'''[[Effect::Decreased libido]]'''

Pupil constriction

*'''[[Effect::Appetite suppression]]'''

~~Increased perspiration~~

*'''[[Effect::Orgasm suppression]]'''

Decreased ~~blood pressure~~

Appetite suppression

Orgasm suppression

]].

}}

|{{effects/cognitive|

~~etazene may produce cognitive impairment and decrease your reflexes significantly, depending on the dose. it might induce slurred speech.~~

*'''[[Effect::Cognitive euphoria]]'''

*'''[[Effect::Anxiety suppression]]'''

~~You may select from a list of transpersonal effects to add below~~ [[~~Subjective effect index#Transpersonal effects|here~~]].

*'''[[Effect::Compulsive redosing]]'''

*'''[[Effect::Dream potentiation]]'''

*'''[[Effect::Irritability]]'''

}}

===Experience reports===

There are currently {{#ask:[[Category:SUBSTANCE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].

{{#ask: [[Category:SUBSTANCE]][[Category:Experience]]|format=ul|Columns=1}}

~~Additional experience reports can be found here:~~

* [https://www.erowid.org/experiences/subs/exp_SUBSTANCE.shtml Erowid Experience Vaults: SUBSTANCE]

==Toxicity and harm potential==

It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this ~~substance~~.

The short-term non-chronic use of opioids is not associated with any physical or neurological toxicity.{{citation needed}}

===~~Lethal dosage~~===

~~===Tolerance to ethazene builds up rather quickly and~~ can be ~~compared~~ to the tolerance ~~build up of fentanyl~~ and ~~other analogues~~. ~~it is unclear how addictive it is but most anecdotal reports find it very easy to abuse~~, ~~mainly due~~ to the ~~compulsive redosing disorder wich often occurs under~~ the ~~influence===~~

===Long term effects===

~~===Dangerous interactions===~~

The long-term use of opioids causes hormonal imbalance in both men and women.

~~{{other opioids~~, ~~alcohol, benzodiazepines, ketamine,}}~~

~~{{etazene does not lower~~ the ~~seizure treshold~~ and ~~does not act on serotonin receptors, it is generally not advised~~ to ~~mix it~~ with other ~~depressants due to~~ the ~~increase in effects~~. ~~that can quickly lead to respiratory depression}}~~

This negative change in endocrine function in males can lead to: reduced libido, erectile dysfunction, fatigue, depression, reduced facial and body hair, decreased muscle mass, and weight gain.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this class of substances.

===Dependence and tolerance potential===

As with other [[opioids]], the chronic use of etazene can be considered [[Addiction potential::highly addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[Opioids#Discontinuation|withdrawal symptoms]] may occur if a person suddenly stops their usage.

Tolerance to many of the effects of Etazene [[Time to full tolerance::develops with prolonged and repeated use]]. The rate at which this occurs develops at different rates for different effects, with tolerance to the constipation-inducing effects developing particularly slowly for instance. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Etazene presents cross-tolerance with [[Cross-tolerance::all other [[opioids]]]], meaning that after the consumption of Etazene all [[opioid]]s will have a reduced effect.

==Legal status==

'''Turkey:''' Etazene is a classed as drug and is illegal to possess, produce, supply, or import.<ref>https://resmigazete.gov.tr/eskiler/2020/10/20201007-8.pdf</ref>

~~==See also==~~

*[[Responsible use]]

==External links==

(List along order below)

* [https://en.wikipedia.org/wiki/SUBSTANCE SUBSTANCE (Wikipedia)]

* SUBSTANCE (Erowid Vault)

* SUBSTANCE ([''PiHKAL'' or ''TiHKAL''] / Isomer Design)

~~==Literature==~~

*[https://en.wikipedia.org/wiki/Etonitazene (Wikipedia)]

* ~~APA formatted reference~~

~~Please see the [[citation formatting guide]] if you need assistance properly formatting citations.~~

-

==References==

Line 101:

Line 90:

==External links==

(List along order below)

* [https://en.wikipedia.org/wiki/SUBSTANCE SUBSTANCE (Wikipedia)]

* SUBSTANCE (Erowid Vault)

* SUBSTANCE ([''PiHKAL'' or ''TiHKAL''] / Isomer Design)

~~==Literature==~~

*[https://en.wikipedia.org/wiki/Etonitazene (Wikipedia)]

* ~~APA formatted reference~~

~~Please see the~~ [~~[citation formatting guide]] if you need assistance properly formatting citations~~.

~~==References==~~

~~<references~~ />

[[Category:Psychoactive substance]][[Category:Proofread]][[Category:Approval]]

[[Category:Psychoactive substance]]

[[Category:Proofread]]

[[Category:Approval]]

@@ Line 2: / Line 2: @@
 {{decree|type=notice|message=This article is in the 'Talk' namespace because it is an unfinished draft. This section is used to host drafts for unpublished articles as well as discussions for published ones. If you'd like to use this area to discuss this draft, please do so in the 'Discussion' section at the very bottom of the page. This notice will be removed once this draft has been approved for publication by an administrator.}}
-{{headerpanel|{{ETAZENE}}}}
+<!--{{headerpanel|{{ETAZENE}}}} -->
-{{SummarySheet}}
+<!-- {SummarySheet}} -->
-{{SubstanceBox/Example}}
+{{SubstanceBox/Etazene}}
+'''Etodesnitazene''' (Desnitroetonitazene, Etazen, '''Etazene''', Etazone) is a benzimidazole derived [[opioid]] [[analgesic]] drug, which was originally developed in the late 1950s alongside [[etonitazene]] and a range of related derivatives.<ref>Vandeputte M, et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of nitazene new synthetic opioids. Authorea. November 12, 2020. doi:10.22541/au.160520665.59016513/v1</ref> It is many times less potent than [[etonitazene]] itself, but still 70x more potent than [[morphine]] in animal studies. Corresponding analogues where the N,N-diethyl group is replaced by [[piperidine]] or [[pyrrolidine]] rings also retain significant activity (10x and 20x morphine respectively).<ref>Hunger A, Kebrle J, Rossi A, Hoffmann K (1960). "Benzimidazol‐Derivate und verwandte Heterocyclen. II. Synthese von 1‐Aminoalkyl‐2‐benzyl‐benzimidazolen". Helvetica Chimica Acta (in German). 43 (3): 800–809. doi:10.1002/hlca.19600430323.</ref>
-For tips on how to properly format a substance article, please refer to this document: [[Content Style Guide - Substance]]
+==History and culture==
+Very little is known about etazene's origin, it first came to the public eye in 2020, when it was first seized by law enforcement. People speculate it is a etonitazene like Research chemical, with similar effects but a much lower LD50.
-==History and culture==
+Etazene is an analgesic drug, first reported in 2020, that has been shown to have approximately one thousand to one thousand five hundred times the potency of morphine in animal models, but only sixty  to seventy times the potency in humans.
-Very little is known about etaznenes origin, it first came to the public eye in 2020, when it was first siezed by law enforcement. People speculate it is a etazene like Research chemical, with similar effects but a much lower LD50
-etazene is an analgesic drug, first reported in 2020, that has been shown to have approximately one thousand to one thousand five hundred times the potency of morphine in animal models, but only sixty  to seventy times the potency in humans.
 Because it is characterized by a strong dependency potential and a tendency to produce profound respiratory depression, it is not used in humans. It is, however, useful in animal models for addiction studies, particularly those requiring the animals to drink or ingest the agent, because it is not as bitter as opiate salts like morphine sulfate.
 ==Pharmacology==
-etazene is a synthetic opioid in the phenylpiperidine family, which includes sufentanil, alfentanil, remifentanil, and carfentanil
+[[Opioid]]s exert their effects by binding to and activating the [[Opioid#Mu_.28.CE.BC.29|μ-opioid]] [[receptor]]. This occurs because opioids structurally mimic endogenous endorphins which are naturally found within the body and also work upon the μ-opioid receptor set. The way in which opioids structurally mimic these natural endorphins results in their [[physical euphoria|euphoria]], [[pain relief]] and [[anxiolytic]] effects. This is because endorphins are responsible for reducing pain, causing sleepiness, and feelings of pleasure. They can be released in response to pain, strenuous exercise, orgasm, or general excitement.
-The structures of opioids share many similarities. Whereas opioids like codeine, hydrocodone, oxycodone, and hydromorphone are synthesized by simple modifications of morphine, etazene and its relatives are synthesized by modifications of meperidine. Meperidine is a fully synthetic opioid, and other members of the phenylpiperidine family like alfentanil and sufentanil are complex versions of this structure. etazene is a weak base that is highly lipid-soluble, protein-bound, and protonated at physiological pH
+==Chemistry==
+Etazene is a synthetic opioid in the benzimidazole family. The structures of opioids share many similarities. Whereas opioids like hydrocodone, oxycodone, and hydromorphone are synthesized by simple modifications of morphine, etazene and its relatives are synthesized using the benzimidazole chemical structure.
 ==Subjective effects==
-subjective effects include:
-euphoria
-muscle relaxation
-sedation
-pupil constriction
-mood lift
-Disclaimer: The effects listed below cite the Subjective Effect Index (SEI),It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses are more likely to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death.
-}}
 {{Preamble/SubjectiveEffects}}
 {{effects/base
 |{{effects/physical|
+The general sensation of methadone can be described as one of euphoria, relaxation, anxiety suppression and pain relief.
+*'''[[Effect::Pain relief]]'''
-You may select physical effects to add below [[
+*'''[[Effect::Physical euphoria]]''' - This particular substance can be considered as less intense in its physical euphoria when compared with that of [[morphine]] or [[diacetylmorphine]] (heroin), but stronger than that of other synthetic opioids such as [[tramadol]]. The sensation itself can be described as extreme feelings of intense physical comfort, warmth, love and bliss.
-Sedation - etazene can be described as much more sedating then other opiates. Even at moderate dosages, etazene can result in overwhelming feelings of sedation and tiredness that is considerably more sedating than that of heroin and oxycodone.
+*'''[[Effect::Itchiness]]'''
-Pain relief - In comparison to other opiates, etazene can be described as a strong analgesic, providing relief even at non-recreational doses.
+*'''[[Effect::Respiratory depression]]''' - At low to moderate doses, this effect results in the sensation that the breath is slowed down mildly to moderately, but does not cause noticeable impairment. At high doses and overdoses, opioid-induced respiratory depression can result in a shortness of breath, abnormal breathing patterns, semi-consciousness, or unconsciousness. Severe overdoses can result in a coma or death without immediate medical attention.
-Physical euphoria - etazene can be considered as less intense in its physical euphoria when compared with that of morphine or diacetylmorphine (heroin). The sensation itself can be described as strong feelings of intense physical comfort, warmth and bliss which spread throughout the body.
+*'''[[Effect::Constipation]]'''
-Itchiness - Unlike other opioids, etazene presents very little itch response due to little to no amounts of released histamines.
+*'''[[Effect::Cough suppression]]'''
-Respiratory depression - In comparison to other opiates, etazene displays this effect at lower doses relative to euphoria then other opiates, and even at low doses results in the sensation that the breath is slowed down mildly to moderately, but does not cause noticeable impairment. At high doses and overdoses, opioid-induced respiratory depression can result in a shortness of breath, abnormal breathing patterns, semi-consciousness, or unconsciousness. Severe overdoses can result in a coma or death without immediate medical attention.
+*'''[[Effect::Difficulty urinating]]'''
-Constipation
+*'''[[Effect::Nausea]]'''
-Cough suppression
+*'''[[Effect::Sedation]]'''
-Decreased libido
+*'''[[Effect::Pupil constriction]]'''
-Difficulty urinating
+*'''[[Effect::Decreased libido]]'''
-Pupil constriction
+*'''[[Effect::Appetite suppression]]'''
-Increased perspiration
+*'''[[Effect::Orgasm suppression]]'''
-Decreased blood pressure
-Appetite suppression
-Orgasm suppression
-]].
 }}
 |{{effects/cognitive|
-etazene may produce cognitive impairment and decrease your reflexes significantly, depending on the dose. it might induce slurred speech.
+*'''[[Effect::Cognitive euphoria]]'''
+*'''[[Effect::Anxiety suppression]]'''
-You may select from a list of transpersonal effects to add below [[Subjective effect index#Transpersonal effects|here]].
+*'''[[Effect::Compulsive redosing]]'''
+*'''[[Effect::Dream potentiation]]'''
+*'''[[Effect::Irritability]]'''
+}}
-}}
 }}
 ===Experience reports===
 There are currently {{#ask:[[Category:SUBSTANCE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
 {{#ask: [[Category:SUBSTANCE]][[Category:Experience]]|format=ul|Columns=1}}
-Additional experience reports can be found here:
-* [https://www.erowid.org/experiences/subs/exp_SUBSTANCE.shtml Erowid Experience Vaults: SUBSTANCE] <!-- Check the link to see if it exists -->
 ==Toxicity and harm potential==
 {{toxicity}}
-It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance.
+The short-term non-chronic use of opioids is not associated with any physical or neurological toxicity.{{citation needed}}
-===Lethal dosage===
-===Tolerance to ethazene builds up rather quickly and can be compared to the tolerance build up of fentanyl and other analogues. it is unclear how addictive it is but most anecdotal reports find it very easy to abuse, mainly due to the compulsive redosing disorder wich often occurs under the influence===
+===Long term effects===
-===Dangerous interactions===
+The long-term use of opioids causes hormonal imbalance in both men and women.
-{{other opioids, alcohol, benzodiazepines, ketamine,}}
-{{etazene does not lower the seizure treshold and does not act on serotonin receptors, it is generally not advised to mix it with other depressants due to the increase in effects. that can quickly lead to respiratory depression}}
+This negative change in endocrine function in males can lead to: reduced libido, erectile dysfunction, fatigue, depression, reduced facial and body hair, decreased muscle mass, and weight gain.
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this class of substances.
+===Dependence and tolerance potential===
+As with other [[opioids]], the chronic use of etazene can be considered [[Addiction potential::highly addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[Opioids#Discontinuation|withdrawal symptoms]] may occur if a person suddenly stops their usage.
+Tolerance to many of the effects of Etazene [[Time to full tolerance::develops with prolonged and repeated use]]. The rate at which this occurs develops at different rates for different effects, with tolerance to the constipation-inducing effects developing particularly slowly for instance. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Etazene presents cross-tolerance with [[Cross-tolerance::all other [[opioids]]]], meaning that after the consumption of Etazene all [[opioid]]s will have a reduced effect.
 ==Legal status==
-{{unscheduled}}
+{{LegalStub}}
+'''Turkey:''' Etazene is a classed as drug and is illegal to possess, produce, supply, or import.<ref>https://resmigazete.gov.tr/eskiler/2020/10/20201007-8.pdf</ref>
-==See also==
-*[[Responsible use]]
 ==External links==
 (List along order below)
-* [https://en.wikipedia.org/wiki/SUBSTANCE SUBSTANCE (Wikipedia)]
-* SUBSTANCE (Erowid Vault)
-* SUBSTANCE ([''PiHKAL'' or ''TiHKAL''] / Isomer Design)
-==Literature==
+*[https://en.wikipedia.org/wiki/Etonitazene (Wikipedia)]
-* APA formatted reference
-Please see the [[citation formatting guide]] if you need assistance properly formatting citations.
+<!-- ==Literature== -->
+-
-==References==
+<!-- ==References== -->
 <references />
@@ Line 101: / Line 90: @@
 ==External links==
 (List along order below)
-* [https://en.wikipedia.org/wiki/SUBSTANCE SUBSTANCE (Wikipedia)]
-* SUBSTANCE (Erowid Vault)
-* SUBSTANCE ([''PiHKAL'' or ''TiHKAL''] / Isomer Design)
-==Literature==
+*[https://en.wikipedia.org/wiki/Etonitazene (Wikipedia)]
-* APA formatted reference
-Please see the [[citation formatting guide]] if you need assistance properly formatting citations.
-==References==
-<references />
-[[Category:Psychoactive substance]][[Category:Proofread]][[Category:Approval]]
+[[Category:Psychoactive substance]]
+[[Category:Proofread]]
+[[Category:Approval]]