4-HO-MET: Difference between revisions

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'''4-Hydroxy-N-methyl-N-ethyltryptamine''' (also known as '''"colour"''',<ref name="erowid">{{cite web|publisher=Erowid|title=4-HO-MET |work=The Vaults of Erowid|publication-date=August 18, 2011|access-date=August 27, 2020|url=https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml}}</ref> '''"methylcybin"''',<ref name="erowid" /> '''"metocin"''',<ref name="erowid" /> and '''4-HO-MET''') is a lesser-known novel [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class.

'''4-Hydroxy-N-methyl-N-ethyltryptamine''' (also known as '''colour''',<ref name="erowid">{{cite web|publisher=Erowid|title=4-HO-MET |work=The Vaults of Erowid|publication-date=August 18, 2011|access-date=August 27, 2020|url=https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml}}</ref> '''methylcybin''',<ref name="erowid" /> '''metocin''',<ref name="erowid" /> and '''4-HO-MET''') is a lesser-known novel [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class.

4-HO-MET is ~~chemically~~ related to [[psilocin]], the active ingredient in [[psilocybin mushrooms]] ('''"magic mushrooms"'''). ~~Like other [[substituted tryptamines]], it produces~~ its ~~psychedelic~~ effects by ~~acting on~~ [[serotonin]] [[receptors]] in the brain.

4-HO-MET is structurally related to [[psilocin]], the active ingredient in [[psilocybin mushrooms]] ('''"magic mushrooms"'''). It is thought to produce its effects by binding to [[serotonin]] [[receptors]] in the brain.

4-HO-MET was first synthesized by the American chemist [[Alexander Shulgin]], who documented it in his 1997 book [[TiHKAL]] ("Tryptamines I Have Known and Loved"). Reports of human use began to surface in the late 2000s following its appearance on the online [[research ~~chemicals~~]] market. It has been sold alongside other psilocybin analogues such as [[4-AcO-DMT]] and [[4-HO-MiPT]].

4-HO-MET was first synthesized by the American chemist [[Alexander Shulgin]], who documented it in his 1997 book [[TiHKAL]] ("Tryptamines I Have Known and Loved"). Reports of human use began to surface in the late 2000s, following its appearance on the online [[research chemical]] market. It has been sold alongside other psilocybin analogues such as [[4-AcO-DMT]] and [[4-HO-MiPT]].

[[Subjective effects]] include [[geometry|geometric visual hallucinations]], [[time distortion]], [[introspection|enhanced introspection]], and [[ego loss]]. Users typically describe 4-HO-MET as a more recreational version of [[psilocybin mushrooms]] or [[psilocin]] (4-HO-DMT) due to its less serious headspace and greater emphasis on visual effects.

[[Subjective effects]] include [[geometry|geometric visual hallucinations]], [[time distortion]], [[introspection|enhanced introspection]], and [[ego loss]]. Users typically describe 4-HO-MET as a more recreational version of [[psilocybin mushrooms]] or [[psilocin]] (4-HO-DMT) due to its less serious headspace and greater emphasis on visual effects. Its psychedelic visuals are reported to be vivid and colorful.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. It is assumed to have a similar risk and toxicity profile as psilocin and [[4-AcO-DMT]] but there is no data to support this. It is highly advised to use [[harm reduction practices]] if using this substance.

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==Subjective effects==

A large body of anecdotal reports suggests that the active dose can vary greatly. Some users report very heavy experiences with doses as low as 17mg, while others report light experiences with doses as high as 30 mg.<ref>{{cite web|publisher=Erowid|title=4-HO-MET: Dose|work=The Vaults of Erowid|publication-date=August 18, 2011|access-date=August 27, 2020|url=https://www.erowid.org/chemicals/4_ho_met/4_ho_met_dose.shtml}}</ref> Possible causes ~~for this observed effect~~ may be attributed to individual differences in neurochemistry and metabolism as well as ~~large~~ variations in ~~the~~ quality ~~of different batches~~ and physical forms (e.g. ~~the~~ HCl vs. fumarate salt) ~~that~~ it ~~has appeared~~ in.

A large body of anecdotal reports suggests that the active dose can vary greatly. Some users report very heavy experiences with doses as low as 17mg, while others report light experiences with doses as high as 30 mg.<ref>{{cite web|publisher=Erowid|title=4-HO-MET: Dose|work=The Vaults of Erowid|publication-date=August 18, 2011|access-date=August 27, 2020|url=https://www.erowid.org/chemicals/4_ho_met/4_ho_met_dose.shtml}}</ref> Possible causes may be attributed to individual differences in neurochemistry and metabolism as well as variations in batch quality and physical forms (e.g. HCl vs. fumarate salt).

The experiences reported indicate hallucinatory states coming in waves of euphoria, swapping from moments of sobriety to intense visuals. Because 4-HO-MET is heavy on visuals and light on cognitive distress, it can be described as a recreational and practical alternative to psilocybin mushrooms, with thematic similarities in visual effects.

{{effects/base

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*'''[[Effect::Scenery slicing]]'''

*'''[[Effect::Symmetrical texture repetition]]'''

*'''[[Effect::Environmental patterning]]'''

*'''[[Effect::Tracers]]'''

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*'''Austria''': 4-HO-MET is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich). {{citation needed}}

*'''Canada''': 4-HO-MET is unscheduled in Canada.

*'''Germany''': 4-HO-MET is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-MET are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>

*'''Japan''': 4-HO-MET is a controlled substance in Japan effective March 25th, 2015.<ref>[https://www.mhlw.go.jp/stf/houdou/0000078803.html "危険ドラッグの成分１６物質を新たに指定薬物に指定"] (in Japanese). 厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)]. Retrieved May 2, 2022.</ref>

*'''Poland:''' 4-HO-MET is illegal to posses, manufacture and sell under "Wykaz środków odurzających i substancji psychotropowych" (Group I-P) <ref>{{Citation | year=2022 | language=polish | title=Wykaz środków odurzających i substancji psychotropowych | url=https://pl.wikipedia.org/wiki/Wykaz_%C5%9Brodk%C3%B3w_odurzaj%C4%85cych_i_substancji_psychotropowych#Grupa_I-P}}</ref>

*'''Sweden''': Sveriges Riksdag added 4-HO-MET to Schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012.<ref>{{cite web|url=https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf|archive-url=https://web.archive.org/web/20181031222225/https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf|archive-date=October 31, 2018|title=Föreskrifter om ändring i Läkemedelsverkets föreskrifter (LVFS 2011:10) om förteckningar över narkotika|date=April 20, 2012|id=LVFS 2012:6|publication-date=April 30, 2012|issn=1101-5225|publisher=Läkemedelsverket [Medical Products Agency ]|language=sv}}</ref>

*'''Switzerland''': 4-HO-MET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>

*'''United Kingdom''': 4-HO-MET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>

*'''United States''': 4-HO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT''), a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}

*'''Poland:''' 4-HO-MET is illegal to posses, manufacture and sell under "Wykaz środków odurzających i substancji psychotropowych" (Group I-P) <ref>https://pl.wikipedia.org/wiki/Wykaz_%C5%9Brodk%C3%B3w_odurzaj%C4%85cych_i_substancji_psychotropowych#Grupa_I-P</ref>

==See also==

@@ Line 2: / Line 2: @@
 {{SubstanceBox/4-HO-MET}}
-'''4-Hydroxy-N-methyl-N-ethyltryptamine''' (also known as '''"colour"''',<ref name="erowid">{{cite web|publisher=Erowid|title=4-HO-MET |work=The Vaults of Erowid|publication-date=August 18, 2011|access-date=August 27, 2020|url=https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml}}</ref> '''"methylcybin"''',<ref name="erowid" /> '''"metocin"''',<ref name="erowid" /> and '''4-HO-MET''') is a lesser-known novel [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class.
+'''4-Hydroxy-N-methyl-N-ethyltryptamine''' (also known as '''colour''',<ref name="erowid">{{cite web|publisher=Erowid|title=4-HO-MET |work=The Vaults of Erowid|publication-date=August 18, 2011|access-date=August 27, 2020|url=https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml}}</ref> '''methylcybin''',<ref name="erowid" /> '''metocin''',<ref name="erowid" /> and '''4-HO-MET''') is a lesser-known novel [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class.
--HO-MET is chemically related to [[psilocin]], the active ingredient in [[psilocybin mushrooms]] ('''"magic mushrooms"'''). Like other [[substituted tryptamines]], it produces its psychedelic effects by acting on [[serotonin]] [[receptors]] in the brain.
+-HO-MET is structurally related to [[psilocin]], the active ingredient in [[psilocybin mushrooms]] ('''"magic mushrooms"'''). It is thought to produce its effects by binding to [[serotonin]] [[receptors]] in the brain.
--HO-MET was first synthesized by the American chemist [[Alexander Shulgin]], who documented it in his 1997 book [[TiHKAL]] ("Tryptamines I Have Known and Loved"). Reports of human use began to surface in the late 2000s following its appearance on the online [[research chemicals]] market. It has been sold alongside other psilocybin analogues such as [[4-AcO-DMT]] and [[4-HO-MiPT]].
+-HO-MET was first synthesized by the American chemist [[Alexander Shulgin]], who documented it in his 1997 book [[TiHKAL]] ("Tryptamines I Have Known and Loved"). Reports of human use began to surface in the late 2000s, following its appearance on the online [[research chemical]] market. It has been sold alongside other psilocybin analogues such as [[4-AcO-DMT]] and [[4-HO-MiPT]].
-[[Subjective effects]] include [[geometry|geometric visual hallucinations]], [[time distortion]], [[introspection|enhanced introspection]], and [[ego loss]]. Users typically describe 4-HO-MET as a more recreational version of [[psilocybin mushrooms]] or [[psilocin]] (4-HO-DMT) due to its less serious headspace and greater emphasis on visual effects.
+[[Subjective effects]] include [[geometry|geometric visual hallucinations]], [[time distortion]], [[introspection|enhanced introspection]], and [[ego loss]]. Users typically describe 4-HO-MET as a more recreational version of [[psilocybin mushrooms]] or [[psilocin]] (4-HO-DMT) due to its less serious headspace and greater emphasis on visual effects. Its psychedelic visuals are reported to be vivid and colorful.
 Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. It is assumed to have a similar risk and toxicity profile as psilocin and [[4-AcO-DMT]] but there is no data to support this. It is highly advised to use [[harm reduction practices]] if using this substance.
@@ Line 66: / Line 66: @@
 ==Subjective effects==
-A large body of anecdotal reports suggests that the active dose can vary greatly. Some users report very heavy experiences with doses as low as 17mg, while others report light experiences with doses as high as 30 mg.<ref>{{cite web|publisher=Erowid|title=4-HO-MET: Dose|work=The Vaults of Erowid|publication-date=August 18, 2011|access-date=August 27, 2020|url=https://www.erowid.org/chemicals/4_ho_met/4_ho_met_dose.shtml}}</ref> Possible causes for this observed effect may be attributed to individual differences in neurochemistry and metabolism as well as large variations in the quality of different batches and physical forms (e.g. the HCl vs. fumarate salt) that it has appeared in.
+A large body of anecdotal reports suggests that the active dose can vary greatly. Some users report very heavy experiences with doses as low as 17mg, while others report light experiences with doses as high as 30 mg.<ref>{{cite web|publisher=Erowid|title=4-HO-MET: Dose|work=The Vaults of Erowid|publication-date=August 18, 2011|access-date=August 27, 2020|url=https://www.erowid.org/chemicals/4_ho_met/4_ho_met_dose.shtml}}</ref> Possible causes may be attributed to individual differences in neurochemistry and metabolism as well as variations in batch quality and physical forms (e.g. HCl vs. fumarate salt).
+The experiences reported indicate hallucinatory states coming in waves of euphoria, swapping from moments of sobriety to intense visuals. Because 4-HO-MET is heavy on visuals and light on cognitive distress, it can be described as a recreational and practical alternative to psilocybin mushrooms, with thematic similarities in visual effects.
 {{Preamble/SubjectiveEffects}}
 {{effects/base
@@ Line 104: / Line 107: @@
 *'''[[Effect::Scenery slicing]]'''
 *'''[[Effect::Symmetrical texture repetition]]'''
+*'''[[Effect::Environmental patterning]]'''
 *'''[[Effect::Tracers]]'''
@@ Line 200: / Line 204: @@
 *'''Austria''': 4-HO-MET is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich). {{citation needed}}
+*'''Canada''': 4-HO-MET is unscheduled in Canada.
 *'''Germany''': 4-HO-MET is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-MET are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>
+*'''Japan''': 4-HO-MET is a controlled substance in Japan effective March 25th, 2015.<ref>[https://www.mhlw.go.jp/stf/houdou/0000078803.html "危険ドラッグの成分１６物質を新たに指定薬物に指定"] (in Japanese). 厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)]. Retrieved May 2, 2022.</ref>
+*'''Poland:''' 4-HO-MET is illegal to posses, manufacture and sell under "Wykaz środków odurzających i substancji psychotropowych" (Group I-P) <ref>{{Citation | year=2022 | language=polish | title=Wykaz środków odurzających i substancji psychotropowych | url=https://pl.wikipedia.org/wiki/Wykaz_%C5%9Brodk%C3%B3w_odurzaj%C4%85cych_i_substancji_psychotropowych#Grupa_I-P}}</ref>
 *'''Sweden''': Sveriges Riksdag added 4-HO-MET to Schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012.<ref>{{cite web|url=https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf|archive-url=https://web.archive.org/web/20181031222225/https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf|archive-date=October 31, 2018|title=Föreskrifter om ändring i Läkemedelsverkets föreskrifter (LVFS 2011:10) om förteckningar över narkotika|date=April 20, 2012|id=LVFS 2012:6|publication-date=April 30, 2012|issn=1101-5225|publisher=Läkemedelsverket [Medical Products Agency ]|language=sv}}</ref>
 *'''Switzerland''': 4-HO-MET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
 *'''United Kingdom''': 4-HO-MET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
 *'''United States''': 4-HO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT''), a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}
-*'''Poland:''' 4-HO-MET is illegal to posses, manufacture and sell under "Wykaz środków odurzających i substancji psychotropowych" (Group I-P) <ref>https://pl.wikipedia.org/wiki/Wykaz_%C5%9Brodk%C3%B3w_odurzaj%C4%85cych_i_substancji_psychotropowych#Grupa_I-P</ref>
 ==See also==