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{{SubstanceBox/4-HO-MET}}{{proofread}}
{{SummarySheet}}
'''4-HO-MET''' ('''4-hydroxy-N-methyl-N-ethyltryptamine''', or '''metocin''', '''methylcybin'''), is a lesser-known psychedelic drug. It is a structural− and functional analog of psilocin as well the 4-hydroxyl analog of MET. 4-HO-MET was first synthesized by [[Alexander Shulgin]]. In his book TiHKAL (Tryptamines I Have Known and Loved), the dosage is listed as 10-20 mɡ<ref>https://www.erowid.org/library/books_online/tihkal/tihkal21.shtm</ref> However, this varies greatly as some report very heavy experiences with doses as low as 17 mg, yet others report light experiences with doses as high as 30 mg.<ref>https://www.erowid.org/chemicals/4_ho_met/4_ho_met_dose.shtml</ref>
{{SubstanceBox/4-HO-MET}}


4-HO-MET produces psilocin-like distortion of color, sound, and form. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. There have been no reports of deaths from 4-HO-MET, even though people have reported taking doses up to 150 mg,<ref>Cosmic Mind Orgy | https://www.erowid.org/experiences/exp.php?ID=71218</ref> more than an order of magnitude above the effective dose.<ref>http://www.erowid.org/experiences/exp.cgi?S1=436&S2=-1&C1=-1&Str=</ref>
'''4-Hydroxy-N-methyl-N-ethyltryptamine''' (also known as '''colour''',<ref name="erowid">{{cite web|publisher=Erowid|title=4-HO-MET |work=The Vaults of Erowid|publication-date=August 18, 2011|access-date=August 27, 2020|url=https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml}}</ref> '''methylcybin''',<ref name="erowid" /> '''metocin''',<ref name="erowid" /> and '''4-HO-MET''') is a lesser-known novel [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class.
4-HO-MET is structurally related to [[psilocin]], the active ingredient in [[psilocybin mushrooms]] ('''"magic mushrooms"'''). It is thought to produce its effects by binding to [[serotonin]] [[receptors]] in the brain.
 
4-HO-MET was first synthesized by the American chemist [[Alexander Shulgin]], who documented it in his 1997 book [[TiHKAL]] ("Tryptamines I Have Known and Loved"). Reports of human use began to surface in the late 2000s, following its appearance on the online [[research chemical]] market. It has been sold alongside other psilocybin analogues such as [[4-AcO-DMT]] and [[4-HO-MiPT]].
 
[[Subjective effects]] include [[geometry|geometric visual hallucinations]], [[time distortion]], [[introspection|enhanced introspection]], and [[ego loss]]. Users typically describe 4-HO-MET as a more recreational version of [[psilocybin mushrooms]] or [[psilocin]] (4-HO-DMT) due to its less serious headspace and greater emphasis on visual effects. Its psychedelic visuals are reported to be vivid and colorful.
 
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. It is assumed to have a similar risk and toxicity profile as psilocin and [[4-AcO-DMT]] but there is no data to support this. It is highly advised to use [[harm reduction practices]] if using this substance.


It is worth noting that this compound has identical subjective effects to [[4-AcO-MET]]. Although human studies concerning the metabolic fate of this drug are lacking, this similarity is hypothesized to be a result of 4-AcO-MET quickly being hydrolyzed into the free phenolic 4-HO-MET. This is similar to how [[4-AcO-DMT]] is thought to be deacetylated to [[4-HO-DMT]] during first pass metabolism and subsequent passes through the liver.
==Chemistry==
==Chemistry==
[[File:SubstitutedTryptamine.png|thumb|294px|right|General formula of a tryptamine molecule.]]
4-HO-MET, or 4-hydroxy-N-ethyl-N-methyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] chemical class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-HO-MET is substituted at R<sub>4</sub> of its indole heterocycle with a hydroxyl functional group OH−. It also contains a methyl group and an ethyl chain bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[MET]]).  
4-HO-MET, or 4-hydroxy-N-methyl-N-ethyltryptamine is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-HO-MET is substituted at R<sub>4</sub> of its indole heterocycle with a hydroxyl functional group OH−; it also contains a methyl group and an ethyl chain bound to the terminal amine R<sub>N</sub> of its tryptamine backbone (MET). 4-HO-MET is a 4-hydroxy analogue of [[4-AcO-MET]] and the N-substituted ethyl homologue of [[4-HO-DMT]]. <ref>http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=21</ref>
 
4-HO-MET is a 4-hydroxy homolog of [[4-AcO-MET]] and the N-substituted ethyl homolog of psilocin ([[4-HO-DMT]]).<ref name="TiHKAL">{{cite book|title=TiHKAL: The Continuation|title-link=TiHKAL|last1=Shulgin|first1=Alexander|last2=Shulgin|first2=Ann|author-link1=Alexander Shulgin|year=1997|publisher=Transform Press|location=United States|isbn=0-9630096-9-9|oclc=38503252|chapter-url=https://erowid.org/library/books_online/tihkal/tihkal21.shtml|chapter=#21. 4-HO-MET}}</ref> It is also the 4-hydroxyl analog of the base tryptamine [[MET]].


==Pharmacology==
==Pharmacology==
{{Main|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
4-AcO-MET's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT System|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]].  
4-HO-MET's [[psychedelic]] effects are believed to come from its activity at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience remains subject to on-going scientific investigation.
 
{| class="wikitable"
|-
!Binding Sites
!Binding Affinity Ki (µM)<ref name="pmid27216487">{{cite journal|last1=Rickli|first1=A.|last2=Moning|first2=O.D.|last3=Hoener|first3=M. C.|last4=Liechti|first4=M. E.|title=Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens|pmid=27216487|issn=0924-977X|oclc=795935172|volume=26|issue=8|pages=1327-1337doi=10.1016/j.euroneuro.2016.05.001|year=2016}}</ref>
|-
|5-HT<sub>1A</sub>
|0.228
|-
|5-HT<sub>2A</sub>
|0.057
|-
|5-HT<sub>2C</sub>
|0.141
|-
|D<sub>1</sub>
|>25
|-
|D<sub>2</sub>
|4
|-
|D<sub>3</sub>
|6.7
|-
|α<sub>1A</sub>
|9.7
|-
|α<sub>2A</sub>
|2.4
|-
|TAAR<sub>1</sub>
|3.1
|-
|H<sub>1</sub>
|0.82
|-
|SERT
|0.2
|-
|DAT
|>26
|-
|NET
|13
|}


However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
==Subjective effects==
==Subjective effects==
The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.
A large body of anecdotal reports suggests that the active dose can vary greatly. Some users report very heavy experiences with doses as low as 17mg, while others report light experiences with doses as high as 30 mg.<ref>{{cite web|publisher=Erowid|title=4-HO-MET: Dose|work=The Vaults of Erowid|publication-date=August 18, 2011|access-date=August 27, 2020|url=https://www.erowid.org/chemicals/4_ho_met/4_ho_met_dose.shtml}}</ref> Possible causes may be attributed to individual differences in neurochemistry and metabolism as well as variations in batch quality and physical forms (e.g. HCl vs. fumarate salt).  
===Physical effects===
The physical effects of 4-HO-MET can be broken down into several components all of which progressively intensify proportional to dosage. These are described below and generally include:


*'''[[Effect::Spontaneous tactile sensations]]''' - The "body high" of 4-HO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
The experiences reported indicate hallucinatory states coming in waves of euphoria, swapping from moments of sobriety to intense visuals. Because 4-HO-MET is heavy on visuals and light on cognitive distress, it can be described as a recreational and practical alternative to psilocybin mushrooms, with thematic similarities in visual effects.
*'''[[Effect::Sedation]]''' - In terms of its effects on the physical energy levels of the tripper, 4-HO-MET is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is often accompanied by compulsive yawning.
*'''[[Effect::Nausea]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Wakefulness]]'''


===Cognitive effects===
{{Preamble/SubjectiveEffects}}
The cognitive effects of 4-HO-MET are described by many as somewhat relaxing, yet fast-paced in style with similarities to [[psychedelics]] such as [[LSD]] or [[2C-B]] which tend to be cognitively energetic and stimulating. The drug contains a large number of typical and unique psychedelic cognitive effects.


The most prominent of these typical effects generally include:
{{effects/base


*'''[[Effect::Current mind state enhancement]]'''
|{{effects/physical|
*'''[[Effect::Thought connectivity]]'''
*'''[[Effect::Stimulation]]''' - 4-HO-MET is primarily stimulating, although it can also be relaxing and stoning. This sets it apart from tryptamines like [[psilocybin]] and [[4-AcO-DMT]], which are primarily sedating.
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Spontaneous bodily sensations]]''' - The "body high" of 4-HO-MET can be described as a pleasurable, warm, soft, and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises following the onset and hits its limit once the peak has been reached.
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Changes in felt bodily form]]''' - This effect is often accompanied by a sense of warmth or [[Unity and interconnectedness#Unity between the self and specific external systems|unity]] and usually occurs around or directly after the peak of the experience. Users can feel as if they are physically part of or conjoined with other objects in a seamless continuity. This is usually reported as feeling comfortable, tranquil and mindful, although it can also manifest in the form of bodily tension
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Nausea]]''' - This effect can be greatly lessened or even completely avoided if the individual has an empty stomach prior to ingestion. It is sometimes recommended that one either refrain from eating for approximately 6 to 8 hours before-hand, or to eat a light meal 2 hours before if the user is feeling physically fatigued and undernourished. The nausea produced by 4-HO-MET is generally considered to be much less prominent than it is with [[Psilocybin#Psilocybin-containing mushrooms|psilocybin mushrooms]], which has been attributed to the lack of fungal-matter the body has to digest when the isolated synthetic form is consumed.
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Temperature regulation suppression]]''' - 4-HO-MET can cause fluctuations in the user's internal sense of temperature, which can manifest as sudden bouts of uncomfortable coldness or warmth.
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Muscle contractions]]''' - The muscle contractions that can occasionally be produced by 4-HO-MET tend to be transient and benign feeling in nature, compared to many other [[tryptamines]], [[phenethylamines]] and [[lysergamides]].
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Increased heart rate]]'''{{citation needed}}
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Olfactory hallucination]]'''  
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Direct communication with the subconscious]]'''
*'''[[Effect::Increased salivation]]'''  
*'''[[Effect::Memory suppression]]'''
*'''[[Effect::Excessive yawning]]''' - This effect seems to be uniquely pronounced among psilocin and related tryptamines. It can occur to a lesser degree on [[LSD]] and very rarely on psychedelic [[phenethylamines]] like [[mescaline]]. It typically occurs in conjunction with [[watery eyes]].
*'''[[Effect::Ego death]]'''
*'''[[Effect::Watery eyes]]'''
*'''[[Effect::Feelings of interdependent opposites]]'''
*'''[[Effect::Teeth grinding]]''' - This component is considerably less intense when compared with that of substances like [[MDMA]] when it does happen to occur, but happens more readily than with related substances like [[psilocin]] or [[psilocybin]], perhaps owing to the greater degree of stimulation it produces.
*'''[[Effect::Delusions]]'''
*'''[[Effect::Brain zaps]]''' - Brain zaps are uncommon and thought to only occur in those who are susceptible to them. They are much less prevalent and intense than those that occur with serotonin releasing agents such as [[MDMA]].
*'''[[Effect::Unity and interconnectedness]]'''
*'''[[Effect::Seizure]]'''{{citation needed}} - Psychedelics are known to lower the seizure threshold and may increase the likelihood of a seizure occurring in those who have a personal susceptibility or a family history of epilepsy. It is not considered a risk in healthy people.


===Visual effects===
}}
A noteworthy aspect regarding this compound is that at sub-psychedelic doses, it appears to still produce visual effects, without any accompanying cognitive effects or "head space".
{{effects/visual|
4-HO-MET is commonly reported to produce visual effects with minimal accompanying cognitive effects or "head space" at lower doses.  


====Enhancements====
====Enhancements====
4-HO-MET presents a full and complete array of possible visual enhancements which generally includes:
*'''[[Effect::Visual acuity enhancement|Acuity enhancement]]'''
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Pattern recognition enhancement]]'''
*'''[[Effect::Pattern recognition enhancement]]'''
*'''[[Effect::Visual acuity enhancement]]'''


====Distortions====
====Distortions====
As for visual distortions and alterations, the effects experienced are detailed below:
*'''[[Effect::Visual drifting|Drifting]]''' ''([[Visual drifting#Melting|melting]], [[Visual drifting#Flowing|flowing]], [[Visual drifting#Breathing|breathing]] and [[Visual drifting#morphing|morphing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, cartoon-like in style, slow and smooth in motion and static in appearance.  
*'''[[Effect::Visual drifting|Drifting]]''' ''([[Visual drifting#Melting|Melting]], [[Visual drifting#Flowing|Flowing]], [[Visual drifting#Breathing|Breathing]] and [[Visual drifting#morphing|morphing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, cartooon-like in style, slow and smooth in motion and static in appearance.  
*'''[[Effect::Tracers]]'''
*'''[[Effect::After images]]'''
*'''[[Effect::After images]]'''
*'''[[Effect::Symmetrical texture repetition]]'''
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::Recursion]]'''
*'''[[Effect::Scenery slicing]]'''
*'''[[Effect::Scenery slicing]]'''
*'''[[Effect::Symmetrical texture repetition]]'''
*'''[[Effect::Environmental patterning]]'''
*'''[[Effect::Tracers]]'''


====[[Effect::Geometry]]====
====[[Effect::Geometry]]====
The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of [[Psilocin]] (4-HO-DMT) and [[4-HO-MiPT]] but with far stronger synthetic digital undertones reminiscent of [[LSD]] or [[2C-B]]. 4-HO-MET can be comprehensively described through its [[Geometry#Variations|variations]] as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. The visuals have a contradictory "natural" and "synthetic" feel to them which is reminiscent of both [[LSD]] and and [[Psilocybin]]. Higher dosages are significantly more likely to result in states of [[Effect::8A Geometry|Level 8A]] visual geometry over [[8B Geometry|Level 8B]].
The visual geometry produced by 4-HO-MET can be described as somewhat similar in appearance to that of [[psilocin]] (4-HO-DMT) and [[4-HO-MiPT]] but with far stronger synthetic digital undertones reminiscent of [[LSD]] or [[2C-B]]. 4-HO-MET can be comprehensively described through its [[Geometry#Variations|variations]] as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in-depth and consistent in intensity. The visuals have a contradictory natural and synthetic feel to them which is reminiscent of both [[LSD]] and [[psilocybin]].


====Hallucinatory states====
====Hallucinatory states====
Line 72: Line 117:


*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucinations]]''' (''[[Effect::Autonomous entities]]'', ''[[Effect::Settings, sceneries, and landscapes]]'', ''[[Effect::Alterations in perspective]]'' and ''[[Effect::Scenarios and plots]]'') - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their [[Internal_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[Effect::geometry]]-based in style and almost exclusively of a religious, spiritual, mystical, science fiction or transcendental nature in overall theme.
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'') - This effect is very consistent in dark environments at appropriately high doses. They can be comprehensively described through their [[Internal_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[Effect::geometry]]-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
*'''[[Effect::External hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'') - They can be comprehensively described through their [[External_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[Effect::geometry]]-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
 
}}
|{{effects/cognitive|


===Auditory effects===
The cognitive effects of 4-HO-MET are described by many as somewhat relaxing yet fast-paced in style with similarities to [[psychedelic]]s such as [[LSD]] or [[2C-B]] which tend to be cognitively energetic and stimulating.
The auditory effects of 4-HO-MET are common in their occurrence and exhibit a full range of effects which commonly include:
 
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Auditory hallucination|Hallucinations]]'''
*'''[[Effect::Delusion]]'''
*'''[[Effect::Autonomous voice communication]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Ego death]]'''
*'''[[Effect::Analysis enhancement]]''' - This effect is consistent in its manifestation and [[outrospection]] dominant.
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Creativity enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased sense of humor]]'''
**'''[[Effect::Laughter fits]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought connectivity]]'''
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Wakefulness]]'''
 
}}
{{effects/auditory|
 
*'''[[Effect::Auditory enhancement]]'''
*'''[[Effect::Auditory distortion]]'''
*'''[[Effect::Auditory hallucination]]'''
 
}}
{{effects/multisensory|
 
*'''[[Effect::Synaesthesia]]''' - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
 
}}
{{effects/transpersonal|
 
Users report that transpersonal effects tend to occur less reliably and impactfully with 4-HO-MET than the closely related [[psilocin]] or [[psilocybin]], and generally require heavier doses to induce. They are listed below as follows:
 
*'''[[Effect::Spirituality enhancement]]'''
*'''[[Effect::Existential self-realization]]'''
*'''[[Effect::Feelings of interdependent opposites]]'''
*'''[[Effect::Unity and interconnectedness]]'''
 
}}
}}
===Combination effects===
 
*'''[[Cannabis]]''' - When used in conjunction with cannabis, both the visual and cognitive effects of 4-HO-MET can be intensified and extended with extreme efficacy. This should be used with extreme caution, however, especially if one is not experienced with psychedelics as this can also amplify the [[anxiety]], [[confusion]] and [[psychosis]] producing aspects of cannabis significantly.
*'''[[Dissociatives]]''' - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced [[Visual_disconnection#Holes.2C_spaces_and_voids|holes, spaces, and voids]] while under the influence of 4-HO-MET can result in significantly more vivid visuals than dissociatives alone present, along with more intense [[internal hallucinations]], [[confusion]], [[delusions]] and chances of a [[psychosis|psychotic reaction]].
*'''[[MDMA]]''' - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of 4-HO-MET are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. The synergy between these substances is unpredictable, and it is best to start with markedly lower dosages than one would take for both substances individually.
*'''[[Alcohol]]''' - This interaction is not typically recommended due to alcohol’s ability to cause [[dehydration]], which can negatively affect a trip if taken in high dosages. This combination is, however, reasonably safe in low doses and when used responsibly, this can often "take the edge off the trip" as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit more in a more stressful way on the body.
*'''[[Benzodiazepines]]''' - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of a 4-HO-MET trip. With higher doses, they are very efficient at stopping [[bad trip|"bad trips"]] at the cost of reduced trip intensity and in the worst case, amnesia and blacking out. Caution is advised when acquiring them for this purpose, however, due to the very high addiction potential that benzodiazepines possess. It is generally advised to refrain from intending to use them at all unless the trip suddenly becomes completely overwhelming.
 
===Experience reports===
Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
{{#ask: [[Category:4-HO-MET]][[Category:Experience]]|format=ul|Columns=1}}
Additional experience reports can be found here:
 
*[https://www.erowid.org/experiences/subs/exp_4HOMET.shtml Erowid Experience Vaults: 4-HO-MET]


==Toxicity and harm potential==
==Toxicity and harm potential==
===Lethal dosage===
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long term health effects of recreational 4-HO-MET use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4-HO-MET is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 4-HO-MET within the [[psychonaut]] community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).
The toxicity and long-term health effects of recreational 4-HO-MET use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-MET is a [[research chemical]] with very little history of human usage. However, there are reports of very high doses leading to drug induced psychosis.<ref>{{cite journal|last1=Täljemark|first1=J.|last2=Johansson|first2=B. A.|year=2012|pmid=22580963|title=Drug-induced acute psychosis in an adolescent first-time user of 4-HO-MET|journal=European Child & Adolescent Psychiatry|volume=21|issue=9|pages=527-528|doi=10.1007/s00787-012-0282-9|issn=1018-8827|eissn=1435-165X|oclc=26585556}}</ref>
 
Anecdotal evidence from those who have tried 4-HO-MET suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.  


There is no current data for the LD<sub>50</sub> of 4-HO-MET, but it is thought to be high.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.


===Tolerance and addiction potential===
===Tolerance and addiction potential===
4-HO-MET does not seem to be physically addictive and many users experience a self-regulating quality. There seems to be a tolerance build up when used consecutively multiple days in a row which requires one to double their dosage each time to achieve the same effects.
4-HO-MET is [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with use. It is most often self-regulating.  
 
Tolerance to the effects of 4-HO-MET is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-MET all psychedelics will have a reduced effect.
 
===Dangerous interactions===
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Psychedelics}}
 
==Legal status==
 
*'''Austria''': 4-HO-MET is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich). {{citation needed}}
*'''Canada''': 4-HO-MET is unscheduled in Canada.
*'''Germany''': 4-HO-MET is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-MET are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>
*'''Japan''': 4-HO-MET is a controlled substance in Japan effective March 25th, 2015.<ref>[https://www.mhlw.go.jp/stf/houdou/0000078803.html "危険ドラッグの成分１６物質を新たに指定薬物に指定"] (in Japanese). 厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)]. Retrieved May 2, 2022.</ref>
*'''Poland:''' 4-HO-MET is illegal to posses, manufacture and sell under "Wykaz środków odurzających i substancji psychotropowych" (Group I-P) <ref>{{Citation | year=2022 | language=polish | title=Wykaz środków odurzających i substancji psychotropowych | url=https://pl.wikipedia.org/wiki/Wykaz_%C5%9Brodk%C3%B3w_odurzaj%C4%85cych_i_substancji_psychotropowych#Grupa_I-P}}</ref>
*'''Sweden''': Sveriges Riksdag added 4-HO-MET to Schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012.<ref>{{cite web|url=https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf|archive-url=https://web.archive.org/web/20181031222225/https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf|archive-date=October 31, 2018|title=Föreskrifter om ändring i Läkemedelsverkets föreskrifter (LVFS 2011:10) om förteckningar över narkotika|date=April 20, 2012|id=LVFS 2012:6|publication-date=April 30, 2012|issn=1101-5225|publisher=Läkemedelsverket [Medical Products Agency ]|language=sv}}</ref>
*'''Switzerland''': 4-HO-MET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': 4-HO-MET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
*'''United States''': 4-HO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT''), a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}


==Legal issues==
*Sveriges riksdag added 4-HO-MET to schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012, published by Medical Products Agency in their regulation '''LVFS 2012:6''' listed as '''4-HO-MET 3-[2-[etyl(metyl)amino]etyl]-1H-indol-4-ol'''<ref>https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf</ref>
*4-HO-MET is a class A drug in the UK, as a result of the tryptamine catch-all clause.
==See also==
==See also==
*[https://www.erowid.org/chemicals/4_ho_met/4_ho_met.shtml 4-HO-MET (erowid)]
 
*[http://en.wikipedia.org/wiki/4-HO-MET 4-HO-MET (Wikipedia)]
*[[Responsible use]]
*[https://www.erowid.org/library/books_online/tihkal/tihkal21.shtml 4-HO-MET (TIHKAL)]
*[[Research chemical]]
*[[Psychedelic]]
*[[Tryptamine]]
*[[4-AcO-MET]]
*[[4-AcO-MET]]
*[[Psychedelic]]
*[[4-AcO-DMT]]
*[[Hallucinogen]]
*[[4-HO-DMT]]
 
==External links==
 
*[https://en.wikipedia.org/wiki/4-HO-MET 4-HO-MET (Wikipedia)]
*[https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml 4-HO-MET (Erowid Vault)]
*[https://isomerdesign.com/PiHKAL/read.php?domain=tk&id=21 4-HO-MET (TiHKAL / Isomer Design)]
 
===Discussion===
 
*[http://www.bluelight.org/vb/threads/250897-The-Big-amp-Dandy-4-HO-MET-Thread The Big & Dandy 4-HO-MET Thread  (Bluelight)]
 
==References==
==References==
<references />
<references />


[[Category:Substance]]
[[Category:Substance]]
[[Category:Psychoactive substance]]
[[Category:Hallucinogen]]
[[Category:Psychedelic]]
[[Category:Psychedelic]]
[[Category:Tryptamine]]
[[Category:Tryptamine]]
[[Category:Research chemical]]


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