Dangerous combinations: Difference between revisions

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[[File:TripSit's Dangerous combination chart.png|400px|thumb|right|A useful chart from [https://tripsit.me/ TripSit.me] which can be used to identify dangerous drug combinations quickly and easily.]]

Although many ~~drugs~~ are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

~~Drug~~ related deaths most commonly occur when combining [[~~depressant~~]]s. Depressants affect parts of the ~~brain that are~~ responsible for ~~respiration~~, and an overdose or combination of these ~~drugs~~ can result in fatal levels of [[respiratory depression]]. Death may also occur when a victim falls into deep enough unconsciousness to ~~suffocate from~~ their own vomit. Lying in the [[recovery position]] can prevent one from ~~inhaling~~ their own vomit.

Substance related deaths most commonly occur when combining [[depressants]]. Depressants affect the parts of the nervous system responsible for breathing, and an overdose or combination of these substances can result in fatal levels of [[respiratory depression]]. Death may also occur when a victim falls into deep enough unconsciousness to aspirate on their own vomit. Lying in the [[recovery position]] can prevent one from suffocating on their own vomit.

[[File:Standard-recovery-position.jpg|250px|thumbnail|Lying in the [[recovery position]] can prevent one from inhaling their own vomit.]]

Another possibly fatal combination of ~~drugs~~ are [[serotonin|serotonergic]] substances, which might cause [[serotonin syndrome]]. This can also be caused alone by an overdose of said substances. [[Serotonin syndrome]] is a result of excess [[serotonin]] in the brain, which can cause [[seizures]], [[anxiety]], tremors, [[nausea]], coma and possibly a deadly fever. Usually this is caused when a user has used an [[anti-depressant]] within the last 2 weeks of consuming said ~~drug~~. These kind of antidepressants include [[MAOI|monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI).

Another possibly fatal combination of substances are [[serotonin|serotonergic]] substances, which might cause [[serotonin syndrome]]. This can also be caused alone by an overdose of said substances. [[Serotonin syndrome]] is a result of excess [[serotonin]] in the brain, which can cause [[seizures]], [[anxiety]], tremors, [[nausea]], coma and possibly a deadly fever. Usually this is caused when a user has used an [[anti-depressant]] within the last 2 weeks of consuming said substance. These kind of antidepressants include [[MAOI|monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI).

== ~~Depressants~~ ==

==Examples==

===[[Benzodiazepines~~]]/[[Thienzodiazepines~~]] ===

===[[Benzodiazepines]]===

*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone~~]], [[Ketamine~~]], [[opioids]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it. It is important to note that this interaction does NOT follow linear pharmacokinetics i.e. the depressant effects from the interaction are multiplicative instead of additive.{{citation needed}}

*'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

*'''[[Stimulants]]''' - It is dangerous to combine benzodiazepines with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified [[disinhibition]] as well as [[benzodiazepine#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only dosing a certain amount of benzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.

===[[Opioids]]===

*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2m2b]], [[alcohol]], [[barbiturates]], [[benzodiazepines]], [[GHB]]/[[GBL]], [[Ketamine]], [[methaqualone]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

*'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

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===[[Alcohol]]===

*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[barbiturates]], [[benzodiazepines]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]], [[Ketamine]],[[phenothiazines]]''<ref>https://web.archive.org/web/20101214113109/http://my.lecom.edu/library/internetresources/journal%20articles/Acute%20Care%20for%20Alcohol%20Intoxication.pdf</ref>) - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

*'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

*'''[[Stimulants]]''' - It is dangerous to combine alcohol, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of alcohol, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified [[disinhibition]] as well as [[Alcohol#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour. This combination can also potentially result in severe dehydration if hydration is not monitored. It also interacts with [[cocaine]] in vivo to produce [[Cocaine#Interactions|cocaethylene]], another psychoactive substance.<ref>Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases | ~~http~~://dmd.aspetjournals.org/content/31/1/16</ref>

*'''[[Stimulants]]''' - It is dangerous to combine alcohol, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of alcohol, which is the main factor most people consider when determining their level of intoxication. Alcohol also appears to have addictive effects on stimulants compared to taking either of them alone. For instance a study found that concentration d-[[methylphenidate]] concentration in the brain are increased by up to 30% when mixed with alcohol. Another study had also found that when there is concurrent administration of [[methamphetamine]] (30 mg intravenously) and [[ethanol]] (1 gm/kg orally over 30 minutes) increased heart rate by 24 beats/minute compared to methamphetamine alone. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified [[disinhibition]] as well as [[Alcohol#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour. This combination can also potentially result in severe dehydration if hydration is not monitored. It also interacts with [[cocaine]] in vivo to produce [[Cocaine#Interactions|cocaethylene]], another psychoactive substance.<ref>{{cite journal | vauthors=((Laizure, S. C.)), ((Mandrell, T.)), ((Gades, N. M.)), ((Parker, R. B.)) | journal=Drug Metabolism and Disposition | title=Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases | volume=31 | issue=1 | pages=16–20 | date=1 January 2003 | url=https://dmd.aspetjournals.org/content/31/1/16 | issn=0090-9556 | doi=10.1124/dmd.31.1.16}}</ref>

*'''[[MAOI]]'''s - This combination can result in dangerous reactions through the way in which tyramine, a chemical commonly found in alcoholic beverages, causes [[increased blood pressure]].

== ~~Serotonergic drugs~~ ==

===[[Psychedelics]]===

===[[MAOI|Monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI) ===

'''NOTE:''' Because of the relatively high unpredictability of psychedelics, it is usually advised (especially if the person has little or no experience) to avoid mixing them with any other substance, even if the mix is considered physically safe. Even a substance like [[Alcohol]], which tends to dull the psychedelic effects, could trigger a state of confusion which might cause the person to have a negative experience.

*'''[[Cannabis]]''' - This combination is very unpredictable. Some people like and advise to smoke during a trip to make the experience more relaxing, but in many cases it seems to potentiate the psychedelic effect and/or make the experience more intricate and confusing. This is usually not physically dangerous, but might cause a [[Bad trip]] by making the experience too overwhelming and disorienting.

*'''[[Stimulants]]''' - This combination tends to increase anxiety, thus increasing the possibility of having a negative experience. If the psychedelic substance used is already stimulating on its own (for example a [[Phenethylamine]]) a mix like this could cause an increase in heart rate and/or other unpleasant physical and psychological symptoms.

===[[MAOI|Monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI)===

*'''[[Empathogens]]''' (''[[MDMA]]'') - This combination can result in [[serotonin syndrome]], which is a result of excess amount of the neurotransmitter [[serotonin]] in the brain. Symptoms include headaches, agitation, hypomania, confusion, anxiety, hallucinations, coma, shivering, sweating, nausea, twitching and tremors. These symptoms can be fatal.

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*'''Other antidepressants''' - This combination can result in [[serotonin syndrome]], which is an excess amount of the neurotransmitter [[serotonin]] in the brain. Symptoms include headaches, agitation, hypomania, confusion, anxiety, hallucinations, coma, shivering, sweating, nausea, twitching and tremors. These symptoms can be fatal.

== See also ==

==See also==

* [[Responsible drug use]]

* [[Recovery position]]

*[[Responsible drug use]]

* [[Research chemicals]]

*[[Recovery position]]

* [http://wiki.tripsit.me/wiki/Drug_combinations Drug combination guide and chart (TripSit])

*[[Research chemicals]]

~~{{Template:Responsible use2}}[[Category:Responsible drug use]]~~

*[http://wiki.tripsit.me/wiki/Drug_combinations Drug combination guide and chart (TripSit])

==References==

[[Category:Responsible drug use]]

@@ Line 3: / Line 3: @@
 [[File:TripSit's Dangerous combination chart.png|400px|thumb|right|A useful chart from [https://tripsit.me/ TripSit.me] which can be used to identify dangerous drug combinations quickly and easily.]]
-Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
-Drug related deaths most commonly occur when combining [[depressant]]s. Depressants affect parts of the brain that are responsible for respiration, and an overdose or combination of these drugs can result in fatal levels of [[respiratory depression]]. Death may also occur when a victim falls into deep enough unconsciousness to suffocate from their own vomit. Lying in the [[recovery position]] can prevent one from inhaling their own vomit.
+Substance related deaths most commonly occur when combining [[depressants]]. Depressants affect the parts of the nervous system responsible for breathing, and an overdose or combination of these substances can result in fatal levels of [[respiratory depression]]. Death may also occur when a victim falls into deep enough unconsciousness to aspirate on their own vomit. Lying in the [[recovery position]] can prevent one from suffocating on their own vomit.
 [[File:Standard-recovery-position.jpg|250px|thumbnail|Lying in the [[recovery position]] can prevent one from inhaling their own vomit.]]
-Another possibly fatal combination of drugs are [[serotonin|serotonergic]] substances, which might cause [[serotonin syndrome]]. This can also be caused alone by an overdose of said substances. [[Serotonin syndrome]] is a result of excess [[serotonin]] in the brain, which can cause [[seizures]], [[anxiety]], tremors, [[nausea]], coma and possibly a deadly fever. Usually this is caused when a user has used an [[anti-depressant]] within the last 2 weeks of consuming said drug. These kind of antidepressants include [[MAOI|monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI).
+Another possibly fatal combination of substances are [[serotonin|serotonergic]] substances, which might cause [[serotonin syndrome]]. This can also be caused alone by an overdose of said substances. [[Serotonin syndrome]] is a result of excess [[serotonin]] in the brain, which can cause [[seizures]], [[anxiety]], tremors, [[nausea]], coma and possibly a deadly fever. Usually this is caused when a user has used an [[anti-depressant]] within the last 2 weeks of consuming said substance. These kind of antidepressants include [[MAOI|monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI).
-== Depressants ==
+==Examples==
-===[[Benzodiazepines]]/[[Thienzodiazepines]] ===
+===[[Benzodiazepines]]===
-*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone]], [[Ketamine]], [[opioids]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
+*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it. It is important to note that this interaction does NOT follow linear pharmacokinetics i.e. the depressant effects from the interaction are multiplicative instead of additive.{{citation needed}}
 *'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
 *'''[[Stimulants]]''' -  It is dangerous to combine benzodiazepines with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified [[disinhibition]] as well as [[benzodiazepine#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only dosing a certain amount of benzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.
 ===[[Opioids]]===
 *'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2m2b]], [[alcohol]], [[barbiturates]], [[benzodiazepines]], [[GHB]]/[[GBL]], [[Ketamine]], [[methaqualone]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
 *'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
@@ Line 22: / Line 24: @@
 ===[[Alcohol]]===
 *'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[barbiturates]], [[benzodiazepines]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]], [[Ketamine]],[[phenothiazines]]''<ref>https://web.archive.org/web/20101214113109/http://my.lecom.edu/library/internetresources/journal%20articles/Acute%20Care%20for%20Alcohol%20Intoxication.pdf</ref>) - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
 *'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
-*'''[[Stimulants]]''' -  It is dangerous to combine alcohol, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of alcohol, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified [[disinhibition]] as well as [[Alcohol#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour. This combination can also potentially result in severe dehydration if hydration is not monitored. It also interacts with [[cocaine]] in vivo to produce [[Cocaine#Interactions|cocaethylene]], another psychoactive substance.<ref>Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases | http://dmd.aspetjournals.org/content/31/1/16</ref>
+*'''[[Stimulants]]''' -  It is dangerous to combine alcohol, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of alcohol, which is the main factor most people consider when determining their level of intoxication. Alcohol also appears to have addictive effects on stimulants compared to taking either of them alone. For instance a study found that concentration d-[[methylphenidate]] concentration in the brain are increased by up to 30% when mixed with alcohol. Another study had also found that when there is concurrent administration of [[methamphetamine]] (30 mg intravenously) and [[ethanol]] (1 gm/kg orally over 30 minutes) increased heart rate by 24 beats/minute compared to methamphetamine alone. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified [[disinhibition]] as well as [[Alcohol#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour. This combination can also potentially result in severe dehydration if hydration is not monitored. It also interacts with [[cocaine]] in vivo to produce [[Cocaine#Interactions|cocaethylene]], another psychoactive substance.<ref>{{cite journal | vauthors=((Laizure, S. C.)), ((Mandrell, T.)), ((Gades, N. M.)), ((Parker, R. B.)) | journal=Drug Metabolism and Disposition | title=Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases | volume=31 | issue=1 | pages=16–20 | date=1 January 2003 | url=https://dmd.aspetjournals.org/content/31/1/16 | issn=0090-9556 | doi=10.1124/dmd.31.1.16}}</ref>
 *'''[[MAOI]]'''s - This combination can result in dangerous reactions through the way in which tyramine, a chemical commonly found in alcoholic beverages, causes [[increased blood pressure]].
-== Serotonergic drugs ==
+===[[Psychedelics]]===
-===[[MAOI|Monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI) ===
+'''NOTE:''' Because of the relatively high unpredictability of psychedelics, it is usually advised (especially if the person has little or no experience) to avoid mixing them with any other substance, even if the mix is considered physically safe. Even a substance like [[Alcohol]], which tends to dull the psychedelic effects, could trigger a state of confusion which might cause the person to have a negative experience.
+*'''[[Cannabis]]''' - This combination is very unpredictable. Some people like and advise to smoke during a trip to make the experience more relaxing, but in many cases it seems to potentiate the psychedelic effect and/or make the experience more intricate and confusing. This is usually not physically dangerous, but might cause a [[Bad trip]] by making the experience too overwhelming and disorienting.
+*'''[[Stimulants]]''' - This combination tends to increase anxiety, thus increasing the possibility of having a negative experience. If the psychedelic substance used is already stimulating on its own (for example a [[Phenethylamine]]) a mix like this could cause an increase in heart rate and/or other unpleasant physical and psychological symptoms.
+===[[MAOI|Monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI)===
 *'''[[Empathogens]]''' (''[[MDMA]]'') - This combination can result in [[serotonin syndrome]], which is a result of excess amount of the neurotransmitter [[serotonin]] in the brain. Symptoms include headaches, agitation, hypomania, confusion, anxiety, hallucinations, coma, shivering, sweating, nausea, twitching and tremors. These symptoms can be fatal.
@@ Line 36: / Line 44: @@
 *'''Other antidepressants''' - This combination can result in [[serotonin syndrome]], which is an excess amount of the neurotransmitter [[serotonin]] in the brain. Symptoms include headaches, agitation, hypomania, confusion, anxiety, hallucinations, coma, shivering, sweating, nausea, twitching and tremors. These symptoms can be fatal.
-== See also ==
+==See also==
-* [[Responsible drug use]]
-* [[Recovery position]]
+*[[Responsible drug use]]
-* [[Research chemicals]]
+*[[Recovery position]]
-* [http://wiki.tripsit.me/wiki/Drug_combinations Drug combination guide and chart (TripSit])
+*[[Research chemicals]]
-{{Template:Responsible use2}}[[Category:Responsible drug use]]
+*[http://wiki.tripsit.me/wiki/Drug_combinations Drug combination guide and chart (TripSit])
 ==References==
-<references/>
+<references />
+{{Template:Responsible use2}}
+[[Category:Responsible drug use]]