Talk:Acetylcholinesterase inhibitor: Difference between revisions

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An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).

An '''acetylcholinesterase inhibitor''' (often abbreviated '''AChEI''') or '''anti-cholinesterase''' is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).

==Acetylcholinesterase inhibitors==

* Caffeine

* ''[[Banisteriopsis caapi]]''

** Harmaline<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref>

** Harmine<ref name="Pubmed-19784581" />

* [[Caffeine]]

* [[Harmala alkaloids]] (found in ''[[Peganum harmala]]'')

** Desoxypeganine<ref>Studies in Natural Products Chemistry, Volume 43, page 43</ref>

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==Dangerous interactions==

{{GenericPanel/warning

| title=Check (~~also with~~ independent research) if your ~~MAOIs~~ also ~~inhibits~~ other substances, most ~~MAOIs~~ are also [[~~cytochrome P450 inhibitors~~]] (and ~~tyramine and a lot of substances are~~ cytochrome P450 ~~substrates) and some are [[Talk:Acetylcholinesterase_inhibitor|acetylcholinesterase inhibitor~~]]~~s (AChEIs) in addition for example!~~

| title=Check (including independent research) if your AChEIs also inhibit other substances, most AChEIs are also [[MAOI]]s and [[cytochrome P450 inhibitors]].

| content=Substances that ~~inhibits~~ the cytochrome P450 ~~system’s~~ ability to ~~metabolize~~ certain drugs, leading to an overall increase in processing times.

| content=Substances that inhibit MAO enzymes and the cytochrome P450 system have the ability to slow the metabolism of certain drugs, leading to an overall increase in processing times.

When the CYP450 system is impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.

When the MAO enzymes and the CYP450 system are impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.

}}

AChEIs combined with [[cholinergic]] substances can result in a [https://en.wikipedia.org/wiki/Cholinergic_crisis cholinergic crisis].

==See also==

* [[Cholinergic]]

==References==

@@ Line 1: / Line 1: @@
-An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).
+An '''acetylcholinesterase inhibitor''' (often abbreviated '''AChEI''') or '''anti-cholinesterase''' is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).
 ==Acetylcholinesterase inhibitors==
-* Caffeine
+* ''[[Banisteriopsis caapi]]''
+** Harmaline<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref>
+** Harmine<ref name="Pubmed-19784581" />
+* [[Caffeine]]
 * [[Harmala alkaloids]] (found in ''[[Peganum harmala]]'')
 ** Desoxypeganine<ref>Studies in Natural Products Chemistry, Volume 43, page 43</ref>
@@ Line 13: / Line 16: @@
 ==Dangerous interactions==
 {{GenericPanel/warning
-| title=Check (also with independent research) if your MAOIs also inhibits other substances, most MAOIs are also [[cytochrome P450 inhibitors]] (and tyramine and a lot of substances are cytochrome P450 substrates) and some are [[Talk:Acetylcholinesterase_inhibitor|acetylcholinesterase inhibitor]]s (AChEIs) in addition for example!<!-- Please do not remove this even if it's just a draft, we need to warn people! -->
+| title=Check (including independent research) if your AChEIs also inhibit other substances, most AChEIs are also [[MAOI]]s and [[cytochrome P450 inhibitors]].
-| content=Substances that inhibits the cytochrome P450 system’s ability to metabolize certain drugs, leading to an overall increase in processing times.
+| content=Substances that inhibit MAO enzymes and the cytochrome P450 system have the ability to slow the metabolism of certain drugs, leading to an overall increase in processing times.
-When the CYP450 system is impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.
+When the MAO enzymes and the CYP450 system are impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.
 }}
 AChEIs combined with [[cholinergic]] substances can result in a [https://en.wikipedia.org/wiki/Cholinergic_crisis cholinergic crisis].
+==See also==
+* [[Cholinergic]]
 ==References==