Talk:Acetylcholinesterase inhibitor: Difference between revisions

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~~==Dangerous interactions==~~

An '''acetylcholinesterase inhibitor''' (often abbreviated '''AChEI''') or '''anti-cholinesterase''' is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).

Acetylcholinesterase inhibitors (~~AChEI~~) ~~should not be taken with [[cholinergic]] substances~~.

~~List of acetylcholinesterase~~ inhibitors:

==Acetylcholinesterase inhibitors==

* [[Peganum harmala]]:

* ''[[Banisteriopsis caapi]]''

** Harmaline<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref>

** Harmine<ref name="Pubmed-19784581" />

* [[Caffeine]]

* [[Harmala alkaloids]] (found in ''[[Peganum harmala]]'')

** Desoxypeganine<ref>Studies in Natural Products Chemistry, Volume 43, page 43</ref>

** Harmaline<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref>

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** Harmol<ref name="Pubmed-19784581" />

** Vasicine (possible)<ref>https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122366</ref>

* Piperine (found in [[Piper nigrum (botany)|Black pepper]] (''Piper nigrum''), and Long pepper (''Piper longum''))

==Dangerous interactions==

{{GenericPanel/warning

| title=Check (including independent research) if your AChEIs also inhibit other substances, most AChEIs are also [[MAOI]]s and [[cytochrome P450 inhibitors]].

| content=Substances that inhibit MAO enzymes and the cytochrome P450 system have the ability to slow the metabolism of certain drugs, leading to an overall increase in processing times.

When the MAO enzymes and the CYP450 system are impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.

}}

AChEIs combined with [[cholinergic]] substances can result in a [https://en.wikipedia.org/wiki/Cholinergic_crisis cholinergic crisis].

==See also==

* [[Cholinergic]]

==References==

[[Category:Acetylcholinesterase inhibitor|*]]

@@ Line 1: / Line 1: @@
-==Dangerous interactions==
+An '''acetylcholinesterase inhibitor''' (often abbreviated '''AChEI''') or '''anti-cholinesterase''' is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).
-Acetylcholinesterase inhibitors (AChEI) should not be taken with [[cholinergic]] substances.
-List of acetylcholinesterase inhibitors:
+==Acetylcholinesterase inhibitors==
-* [[Peganum harmala]]:
+* ''[[Banisteriopsis caapi]]''
+** Harmaline<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref>
+** Harmine<ref name="Pubmed-19784581" />
+* [[Caffeine]]
+* [[Harmala alkaloids]] (found in ''[[Peganum harmala]]'')
 ** Desoxypeganine<ref>Studies in Natural Products Chemistry, Volume 43, page 43</ref>
 ** Harmaline<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref>
@@ Line 9: / Line 12: @@
 ** Harmol<ref name="Pubmed-19784581" />
 ** Vasicine (possible)<ref>https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122366</ref>
+* Piperine (found in [[Piper nigrum (botany)|Black pepper]] (''Piper nigrum''), and Long pepper (''Piper longum''))
+==Dangerous interactions==
+{{GenericPanel/warning
+| title=Check (including independent research) if your AChEIs also inhibit other substances, most AChEIs are also [[MAOI]]s and [[cytochrome P450 inhibitors]].
+| content=Substances that inhibit MAO enzymes and the cytochrome P450 system have the ability to slow the metabolism of certain drugs, leading to an overall increase in processing times.
+When the MAO enzymes and the CYP450 system are impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.
+}}
+AChEIs combined with [[cholinergic]] substances can result in a [https://en.wikipedia.org/wiki/Cholinergic_crisis cholinergic crisis].
+==See also==
+* [[Cholinergic]]
+==References==
+{{reflist}}
+[[Category:Acetylcholinesterase inhibitor|*]]