LAE-32: Difference between revisions - PsychonautWiki Archive

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'''Lysergic acid ethylamide''' (also known as '''LAE-32''', '''LAE''', and '''d-ethyllysergamide''') is a lesser-known [[psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class. It is one of the least known and least researched psychedelic substances.

The pharmacology of LAE-32 is complex{{citation needed}}, but it acts primarily by binding to [[serotonin]] [[receptors]] in the brain, much like LSD and other serotonergic psychedelics.{{citation needed}}

==History and culture==

===The CIA and Project MKULTRA Findings===

LAE-32 was experimented with by the CIA as part of Project MKULTRA. It was reported to create a condition similar to that of schizophrenia in mentally healthy individuals, characterized by indifference and depersonalization. While it was reported that, when used on schizophrenics, it created a condition that allowed the patients to become indifferent to their hallucinations and cease hallucinatory excitation.

==Chemistry==

LAE-32, or d-lysergic acid ethylamide, is a semisynthetic substance of the [[lysergamide]] family.

Its chemical structure consists of a bicyclic hexahydroindole ring fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline an N, generally N-ethyl carboxamide is bound, LAE-32 is additionally substituted at carbon 6 with a methyl group.

==Pharmacology==

LAE-32 most likely acts by binding to serotonin receptors in the brain. It may, like [[LSD]], bind to dopamine receptors as well.

==Subjective effects==

The subjective effects of LAE-32 are reportedly mainly sedating and depersonalizing, creating a state of indifference in users.

{{effects/base

|{{effects/physical|

*'''[[Effect::Pupil dilation]]'''

*'''[[Effect::Sedation]]''' - This effect is mild compared to traditional [[sedatives]] such as [[barbiturates]] and [[benzodiazepines]].

}}

|{{effects/cognitive|

*'''[[Effect::Personal bias suppression]]'''

*'''[[Effect::Motivation suppression]]''' - LAE-32 is unique among psychedelics for its ability to suppress willpower.

*'''[[Effect::Personality regression]]'''

}}

===Dangerous interactions===

*'''[[UncertainInteraction::Cannabis]]''' - Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Extreme caution is advised when using this combination as it can significantly increase the chances of a negative psychological reaction like [[anxiety]], [[confusion]] and [[psychosis]]. Users are advised to start off with only a fraction of their usual cannabis dose and take long breaks between hits to avoid over intake.

*'''[[UncertainInteraction::Amphetamines]]''' & '''[[UncertainInteraction::Cocaine]]''' - Stimulants increase [[anxiety]] levels and the risk of [[thought loops]] which can lead to negative experiences.

*'''[[UnsafeInteraction::Tramadol]]''' - Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

==Legal status==

LAE-32 is not explicitly illegal in any nation, but it is possibly illegal to possess in the United States for purposes of consumption due to the Federal Analog Act.

==See also==

* [[Responsible use (Hallucinogens)]]

* [[Psychedelics]]

* [[Lysergamide]]

* [[LSD]]

* [[Psilocin]]

* [[Mescaline]]

==External links==

* [https://en.wikipedia.org/wiki/LAE-32 LAE-32 (Wikipedia)]

* [https://imgur.com/a/Y4CTo Project MKULTRA: LSD and LAE-32 (Imgur images of declassified CIA MKULTRA documents)]

* [https://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=5311 LAE-32 (TiHKAL / Isomer Design)]

==References==

[[Category:Psychoactive substance]]

[[Category:Entheogen]]

[[Category:Hallucinogen]]

[[Category:Psychedelic]]

[[Category:Lysergamide]]

[[Category:Approval]]

[[Category:Proofread]]

@@ Line 1: / Line 1: @@
+{{approval}}
+{{stub}}
 {{SummarySheet}}
 {{SubstanceBox/LAE-32}}
+'''Lysergic acid ethylamide''' (also known as '''LAE-32''', '''LAE''', and '''d-ethyllysergamide''') is a lesser-known [[psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class. It is one of the least known and least researched psychedelic substances.
+The pharmacology of LAE-32 is complex{{citation needed}}, but it acts primarily by binding to [[serotonin]] [[receptors]] in the brain, much like LSD and other serotonergic psychedelics.{{citation needed}}
+==History and culture==
+{{historyStub}}
+===The CIA and Project MKULTRA Findings===
+LAE-32 was experimented with by the CIA as part of Project MKULTRA. It was reported to create a condition similar to that of schizophrenia in mentally healthy individuals, characterized by indifference and depersonalization. While it was reported that, when used on schizophrenics, it created a condition that allowed the patients to become indifferent to their hallucinations and cease hallucinatory excitation.
+==Chemistry==
+LAE-32, or d-lysergic acid ethylamide, is a semisynthetic substance of the [[lysergamide]] family.
+Its chemical structure consists of a bicyclic hexahydroindole ring fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline an N, generally N-ethyl carboxamide is bound, LAE-32 is additionally substituted at carbon 6 with a methyl group.
+==Pharmacology==
+{{Further|Serotonergic psychedelic}}
+LAE-32 most likely acts by binding to serotonin receptors in the brain. It may, like [[LSD]], bind to dopamine receptors as well.
+==Subjective effects==
+The subjective effects of LAE-32 are reportedly mainly sedating and depersonalizing, creating a state of indifference in users.
+{{Preamble/SubjectiveEffects}}
+{{effects/base
+|{{effects/physical|
+*'''[[Effect::Pupil dilation]]'''
+*'''[[Effect::Sedation]]''' - This effect is mild compared to traditional [[sedatives]] such as [[barbiturates]] and [[benzodiazepines]].
+}}
+|{{effects/cognitive|
+*'''[[Effect::Personal bias suppression]]'''
+*'''[[Effect::Motivation suppression]]''' - LAE-32 is unique among psychedelics for its ability to suppress willpower.
+*'''[[Effect::Personality regression]]'''
+}}
+}}
+===Dangerous interactions===
+{{DangerousInteractions/Intro}}
+*'''[[UncertainInteraction::Cannabis]]''' - Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Extreme caution is advised when using this combination as it can significantly increase the chances of a negative psychological reaction like [[anxiety]], [[confusion]] and [[psychosis]]. Users are advised to start off with only a fraction of their usual cannabis dose and take long breaks between hits to avoid over intake.
+*'''[[UncertainInteraction::Amphetamines]]''' & '''[[UncertainInteraction::Cocaine]]''' - Stimulants increase [[anxiety]] levels and the risk of [[thought loops]] which can lead to negative experiences.
+*'''[[UnsafeInteraction::Tramadol]]''' - Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
+==Legal status==
+LAE-32 is not explicitly illegal in any nation, but it is possibly illegal to possess in the United States for purposes of consumption due to the Federal Analog Act.
+==See also==
+* [[Responsible use (Hallucinogens)]]
+* [[Psychedelics]]
+* [[Lysergamide]]
+* [[LSD]]
+* [[Psilocin]]
+* [[Mescaline]]
+==External links==
+* [https://en.wikipedia.org/wiki/LAE-32 LAE-32 (Wikipedia)]
+* [https://imgur.com/a/Y4CTo Project MKULTRA: LSD and LAE-32 (Imgur images of declassified CIA MKULTRA documents)]
+* [https://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=5311 LAE-32 (TiHKAL / Isomer Design)]
+==References==
+{{reflist|2}}
+[[Category:Psychoactive substance]]
+[[Category:Entheogen]]
+[[Category:Hallucinogen]]
+[[Category:Psychedelic]]
+[[Category:Lysergamide]]
+[[Category:Approval]]
+[[Category:Proofread]]
+{{#set:Featured=true}}