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LAE-32: Difference between revisions

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    <!-- Special Parameters -->
'''Lysergic acid ethylamide''' (also known as '''LAE-32''', '''LAE''', and '''d-ethyllysergamide''') is a lesser-known [[psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class. It is one of the least known and least researched psychedelic substances.
    |displayClasses={{{displayClasses|}}}
    |MaterialTable_MaxWidth=250px
    |MaterialTable_Title={{PAGENAME}}


    <!-- Modules -->
The pharmacology of LAE-32 is complex{{citation needed}}, but it acts primarily by binding to [[serotonin]] [[receptors]] in the brain, much like LSD and other serotonergic psychedelics.{{citation needed}}
    |ModuleSource=false
    |ModuleCombination=false
    |ModuleStructure=true
    |ModuleNomenclature=true
    |ModuleClassMembership=true
    |ModuleROA=true


    <!-- Source -->
==History and culture==
    |PhotoImageFile=
{{historyStub}}
    |PhotoImageWidth=
===The CIA and Project MKULTRA Findings===
    |PhotoImageCaption=
LAE-32 was experimented with by the CIA as part of Project MKULTRA. It was reported to create a condition similar to that of schizophrenia in mentally healthy individuals, characterized by indifference and depersonalization. While it was reported that, when used on schizophrenics, it created a condition that allowed the patients to become indifferent to their hallucinations and cease hallucinatory excitation.


    <!-- Combination -->
==Chemistry==
    |CombinationImage1_Caption=
LAE-32, or d-lysergic acid ethylamide, is a semisynthetic substance of the [[lysergamide]] family.
    |CombinationImage1_File=
    |CombinationImage1_Width=


    |CombinationImage2_Caption=
Its chemical structure consists of a bicyclic hexahydroindole ring fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline an N, generally N-ethyl carboxamide is bound, LAE-32 is additionally substituted at carbon 6 with a methyl group.
    |CombinationImage2_File=
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    |CombinationImage3_Caption=
==Pharmacology==
    |CombinationImage3_File=
{{Further|Serotonergic psychedelic}}
    |CombinationImage3_Width=
LAE-32 most likely acts by binding to serotonin receptors in the brain. It may, like [[LSD]], bind to dopamine receptors as well.


    <!-- Structure -->
==Subjective effects==
    |MolecularStructureCaption=Molecular structure of lysergic acid ethylamide
The subjective effects of LAE-32 are reportedly mainly sedating and depersonalizing, creating a state of indifference in users.
    |SkeletalImageFile=File:LAE-32.svg
    |SkeletalImageWidth=245px
    |3DImageFile=
    |3DImageWidth=


    <!-- Nomenclature -->
{{Preamble/SubjectiveEffects}}
    |NameCommon=LAE-32, LAE
{{effects/base
    |NameSubstitution=d-Lysergic acid ethylamide
    |NameSystematic=N-ethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide


    <!-- Class Membership -->
|{{effects/physical|
    |EffectClass=[[psychoactive class::Psychedelic]]
    |ChemicalClass=[[chemical class::Lysergamide]]


    <!-- Dosage/Duration per ROA -->
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Sedation]]''' - This effect is mild compared to traditional [[sedatives]] such as [[barbiturates]] and [[benzodiazepines]].
}}
|{{effects/cognitive|


    |OralROA=false
*'''[[Effect::Personal bias suppression]]'''
    |OralROA_Collapsed=true
*'''[[Effect::Motivation suppression]]''' - LAE-32 is unique among psychedelics for its ability to suppress willpower.
    |OralROA_Caption=
*'''[[Effect::Personality regression]]'''
    |OralROA_Bioavailability=
    |OralROA_Threshold=
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    |OralROA_Comeup=
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    |OralROA_Offset=
    |OralROA_Aftereffects=


    |SublingualROA=true
}}
    |SublingualROA_Collapsed=false
}}
    |SublingualROA_Caption=
===Dangerous interactions===
    |SublingualROA_Bioavailability=
{{DangerousInteractions/Intro}}
    |SublingualROA_Microdose=
    |SublingualROA_Threshold=[[Sublingual threshold dose::0.5-1.5]] [[Sublingual dose units::mg]]
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    |SublingualROA_Aftereffects=
 
    |BuccalROA=false
    |BuccalROA_Collapsed=true
    |BuccalROA_Caption=Presumes no tolerance
    |BuccalROA_Bioavailability=
    |BuccalROA_Threshold=< x mg
    |BuccalROA_Light=x - x mg
    |BuccalROA_Common=x - x mg
    |BuccalROA_Strong=x - x mg
    |BuccalROA_Heavy= >  mg
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    |BuccalROA_Duration=x - x hours
    |BuccalROA_Onset=x minutes
    |BuccalROA_Peak=x hours
    |BuccalROA_Offset=x hours
    |BuccalROA_Aftereffects=x hours
 
    |InsufflatedROA=false
    |InsufflatedROA_Collapsed=true
    |InsufflatedROA_Caption=
    |InsufflatedROA_Bioavailability=
    |InsufflatedROA_Threshold=< x mg
    |InsufflatedROA_Light=x - x mg
    |InsufflatedROA_Common=x - x mg
    |InsufflatedROA_Strong=x - x mg
    |InsufflatedROA_Heavy= >  mg
    |InsufflatedROA_TimelineFile=
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    |InsufflatedROA_Duration=x - x hours
    |InsufflatedROA_Onset=x minutes
    |InsufflatedROA_Peak=x hours
    |InsufflatedROA_Offset=x hours
    |InsufflatedROA_Aftereffects=x hours
 
    |RectalROA=false
    |RectalROA_Collapsed=true
    |RectalROA_Caption=Presumes no tolerance
    |RectalROA_Bioavailability=
    |RectalROA_Threshold=< x mg
    |RectalROA_Light=x - x mg
    |RectalROA_Common=x - x mg
    |RectalROA_Strong=x - x mg
    |RectalROA_Heavy= >  mg
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    |RectalROA_Onset=x minutes
    |RectalROA_Peak=x hours
    |RectalROA_Offset=x hours
    |RectalROA_Aftereffects=x hours


    |TransdermalROA=false
*'''[[UncertainInteraction::Cannabis]]''' - Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Extreme caution is advised when using this combination as it can significantly increase the chances of a negative psychological reaction like [[anxiety]], [[confusion]] and [[psychosis]]. Users are advised to start off with only a fraction of their usual cannabis dose and take long breaks between hits to avoid over intake.
    |TransdermalROA_Collapsed=true
*'''[[UncertainInteraction::Amphetamines]]''' & '''[[UncertainInteraction::Cocaine]]''' - Stimulants increase [[anxiety]] levels and the risk of [[thought loops]] which can lead to negative experiences.
    |TransdermalROA_Caption=Presumes no tolerance
*'''[[UnsafeInteraction::Tramadol]]''' - Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
    |TransdermalROA_Bioavailability=
    |TransdermalROA_Threshold=< x mg
    |TransdermalROA_Light=x - x mg
    |TransdermalROA_Common=x - x mg
    |TransdermalROA_Strong=x - x mg
    |TransdermalROA_Heavy= >  mg
    |TransdermalROA_TimelineFile=
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    |TransdermalROA_Duration=x - x hours
    |TransdermalROA_Onset=x minutes
    |TransdermalROA_Peak=x hours
    |TransdermalROA_Offset=x hours
    |TransdermalROA_Aftereffects=x hours


    |SubcutaneousROA=false
==Legal status==
    |SubcutaneousROA_Collapsed=true
LAE-32 is not explicitly illegal in any nation, but it is possibly illegal to possess in the United States for purposes of consumption due to the Federal Analog Act.
    |SubcutaneousROA_Caption=Presumes no tolerance
    |SubcutaneousROA_Bioavailability=
    |SubcutaneousROA_Threshold=< x mg
    |SubcutaneousROA_Light=x - x mg
    |SubcutaneousROA_Common=x - x mg
    |SubcutaneousROA_Strong=x - x mg
    |SubcutaneousROA_Heavy= >  mg
    |SubcutaneousROA_TimelineFile=
    |SubcutaneousROA_TimelineWidth=
    |SubcutaneousROA_Duration=x - x hours
    |SubcutaneousROA_Onset=x minutes
    |SubcutaneousROA_Peak=x hours
    |SubcutaneousROA_Offset=x hours
    |SubcutaneousROA_Aftereffects=x hours


    |IntramuscularROA=false
==See also==
    |IntramuscularROA_Collapsed=true
* [[Responsible use (Hallucinogens)]]
    |IntramuscularROA_Caption=Presumes no tolerance
* [[Psychedelics]]
    |IntramuscularROA_Bioavailability=
* [[Lysergamide]]
    |IntramuscularROA_Threshold=< x mg
* [[LSD]]
    |IntramuscularROA_Light=x - x mg
* [[Psilocin]]
    |IntramuscularROA_Common=x - x mg
* [[Mescaline]]
    |IntramuscularROA_Strong=x - x mg
    |IntramuscularROA_Heavy= >  mg
    |IntramuscularROA_TimelineFile=
    |IntramuscularROA_TimelineWidth=
    |IntramuscularROA_Duration=x - x hours
    |IntramuscularROA_Onset=x minutes
    |IntramuscularROA_Peak=x hours
    |IntramuscularROA_Offset=x hours
    |IntramuscularROA_Aftereffects=x hours


    |IntravenousROA=false
==External links==
    |IntravenousROA_Collapsed=true
* [https://en.wikipedia.org/wiki/LAE-32 LAE-32 (Wikipedia)]
    |IntravenousROA_Caption=Presumes no tolerance
* [https://imgur.com/a/Y4CTo Project MKULTRA: LSD and LAE-32 (Imgur images of declassified CIA MKULTRA documents)]
    |IntravenousROA_Bioavailability=
* [https://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=5311 LAE-32 (TiHKAL / Isomer Design)]
    |IntravenousROA_Threshold=< x mg
    |IntravenousROA_Light=x - x mg
    |IntravenousROA_Common=x - x mg
    |IntravenousROA_Strong=x - x mg
    |IntravenousROA_Heavy= >  mg
    |IntravenousROA_TimelineFile=
    |IntravenousROA_TimelineWidth=
    |IntravenousROA_Duration=x - x hours
    |IntravenousROA_Onset=x minutes
    |IntravenousROA_Peak=x hours
    |IntravenousROA_Offset=x hours
    |IntravenousROA_Aftereffects=x hours
}}
{{SummarySheet}}


'''Lysergic acid ethylamide''' (also known as '''LAE-32''', '''LAE''', and '''d-ethyllysergamide''') is a semisynthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class that is structurally similar to LSD.
==References==
LAE-32 is one of the least known and least researched psychedelic substances.
{{reflist|2}}
The pharmacology of LAE-32 is complex{{citation needed}}, but it acts primarily by binding to [[serotonin]] [[receptors]] in the brain, much like LSD and other serotonergic psychedelics.{{citation needed}}
[[Category:Psychoactive substance]]
 
[[Category:Entheogen]]
==The CIA and Project MKULTRA Findings==
[[Category:Hallucinogen]]
LAE-32 was experimented with by the CIA as part of Project MKULTRA. It was reported to create a condition similar to that of schizophrenia in mentally healthy individuals, characterized by indifference and depersonalization. While it was reported that, when used on schizophrenics, it created a condition that allowed the patients to become indifferent to their hallucinations and cease hallucinatory excitation.
[[Category:Psychedelic]]
[[Category:Lysergamide]]
[[Category:Approval]]
[[Category:Proofread]]
{{#set:Featured=true}}
Retrieved from "https://psy.st/wiki/LAE-32"