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Talk:4-Methylaminorex: Difference between revisions
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{{SummarySheet}} | {{SummarySheet}} | ||
{{SubstanceBox/ | {{Template talk:SubstanceBox/4-Methylaminorex}} | ||
'''4-Methylaminorex''' ('''4-MAR''', '''4-MAX''') is a stimulant drug of the 2-amino-5-aryloxazoline class that was first synthesized in 1960 by McNeil Laboratories.<ref>2-amino-5-aryloxazoline compositions and methods of using same | https://www.google.com/patents/US3278382</ref> It is also known by its street names "U4Euh" ("Euphoria") and "Ice". It is banned in many countries as a stimulant. | '''4-Methylaminorex''' ('''4-MAR''', '''4-MAX''') is a stimulant drug of the 2-amino-5-aryloxazoline class that was first synthesized in 1960 by McNeil Laboratories.<ref>2-amino-5-aryloxazoline compositions and methods of using same | https://www.google.com/patents/US3278382</ref> It is also known by its street names "U4Euh" ("Euphoria") and "Ice". It is banned in many countries as a stimulant. | ||
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==Pharmacology== | ==Pharmacology== | ||
It produces long-lasting effects, generally up to 16 hours in duration if taken orally and up to 12 hours if smoked or insufflated. Large doses have been reported anecdotally to last up to 36 hours. The effects are stimulant in nature, producing euphoria, an increase in attention, and increased cognition. Anecdotally, it has been reported to produce effects similar to [[nootropics]], however, there is no research to support the claim that it is any different or more effective than other psychostimulants in this respect. Moreover, 4-methylaminorex does not have the established safety profile of widely used clinical psychostimulants such as [[methylphenidate]] and [[dextroamphetamine]]. | It produces long-lasting effects, generally up to 16 hours in duration if taken orally and up to 12 hours if smoked or insufflated. Large doses have been reported anecdotally to last up to 36 hours. The effects are stimulant in nature, producing euphoria, an increase in attention, and increased cognition. Anecdotally, it has been reported to produce effects similar to [[nootropics]], however, there is no research to support the claim that it is any different or more effective than other psychostimulants in this respect. Moreover, 4-methylaminorex does not have the established safety profile of widely used clinical psychostimulants such as [[methylphenidate]] and [[dextroamphetamine]].{{citation needed|date=November 2020}} | ||
==Subjective effects== | ==Subjective effects== | ||
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{{Preamble/SubjectiveEffects}} | {{Preamble/SubjectiveEffects}} | ||
{{effects/base | |||
|{{effects/physical| | |||
*'''[[Effect::Stimulation]]''' | *'''[[Effect::Stimulation]]''' | ||
*'''[[Effect::Tactile enhancement]]''' - | *'''[[Effect::Tactile enhancement]]''' - | ||
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*'''[[Effect::Teeth grinding]]''' | *'''[[Effect::Teeth grinding]]''' | ||
}}|{{effects/cognitive| | |||
*'''[[Effect::Cognitive euphoria]]''' | *'''[[Effect::Cognitive euphoria]]''' | ||
*'''[[Effect::Thought acceleration]]''' | *'''[[Effect::Thought acceleration]]''' | ||
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*'''[[Effect::Time distortion]]''' | *'''[[Effect::Time distortion]]''' | ||
}}|{{effects/aftereffects| | |||
The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include: | The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include: | ||
*'''[[Effect::Anxiety]]''' | *'''[[Effect::Anxiety]]''' | ||
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*'''[[Effect::Thought deceleration]]''' | *'''[[Effect::Thought deceleration]]''' | ||
*'''[[Effect::Wakefulness]]''' | *'''[[Effect::Wakefulness]]''' | ||
}} | |||
}} | |||
===Experience reports=== | |||
There are currently {{#ask:[[Category:SUBSTANCE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]]. | |||
{{#ask: [[Category:SUBSTANCE]][[Category:Experience]]|format=ul|Columns=1}} | |||
Additional experience reports can be found here: | |||
* [https://erowid.org/experiences/subs/exp_4Methylaminorex.shtml Erowid Experience Vaults: 4-Methylaminorex] | |||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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===Dangerous interactions=== | ===Dangerous interactions=== | ||
{{DangerousInteractions}} | |||
{{DangerousInteractions/Intro}} | {{DangerousInteractions/Intro}} | ||
{{DangerousInteractions/Stimulants}} | |||
{{DangerousInteractions/MAOI|nt=dopamine}} | {{DangerousInteractions/MAOI|nt=dopamine}} | ||
==== | ==Legal status== | ||
"2-Amino-4-methyl-5-phenyl-2-oxazoline (4-methylaminorex)" and "any material, compound, mixture, or preparation that contains any quantity of" it "or that contains any of [its] salts, isomers, including optical, positional, or geometric isomers, and salts of isomers, if the existence of such salts, isomers, and salts of isomers is possible" is a Schedule I | *'''Australia''': In Australia, 4-Methylaminorex is listed as Schedule 9, making it legal only for scientific and medical research.<ref>{{cite web|url=http://www.comlaw.gov.au/ComLaw/Legislation/LegislativeInstrument1.nsf/previewlodgmentattachments/FDEA253A6FEDDFC9CA257608007EB777/$file/PoisonsStandard2009SUSDP24.htm |title=Poisons Standard 2009 |accessdate=2009-09-02 }}</ref> | ||
*'''Canada''': In Canada, 4-Methylaminorex is listed as Schedule III.<ref>{{cite web|url=http://laws.justice.gc.ca/en/showdoc/cs/C-38.8/sc:2/20090901/en |title=Controlled Drugs and Substances Act |accessdate=2009-09-02 }}</ref> | |||
*'''Netherlands''': In the Netherlands, aminorex (4-methylaminorex is a designer drug 2014) is a List I drug of the Opium Law.<ref>{{cite web|url=http://www.douane.nl/bibliotheek/handboeken/vgem/hvgem_10-03-00-11.html |title=Bijlage 1 Lijst I Opiumwetmiddelen |accessdate=2009-09-02 |deadurl=yes |archiveurl=https://web.archive.org/web/20090625181630/http://www.douane.nl/bibliotheek/handboeken/vgem/hvgem_10-03-00-11.html |archivedate=2009-06-25 }}</ref> It is not approved by the CBG, and so it is designated as lacking any medical use. | |||
*'''United Kingdom''': In the United Kingdom, 4-Methylaminorex is listed as Class A.<ref>{{cite web|url=http://www.dhsspsni.gov.uk/pas-class-a.pdf |title=LIST OF DRUGS CURRENTLY CONTROLLED UNDER CLASS A |accessdate=2009-09-02 |format=PDF }}</ref> | |||
*'''United States''': In the United States, (±)-''cis''-4-methylaminorex was placed in Schedule I of the Controlled Substances Act shortly after its emergence as a recreational drug in the mid-1980s.<ref>{{cite web|url=http://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_11.htm |title=Section 1308.11 Schedule I |accessdate=2009-09-02 | archiveurl= https://web.archive.org/web/20090827043725/http://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_11.htm| archivedate= 27 August 2009 <!--DASHBot-->| deadurl= no}}</ref> Manufacturing the ''trans'' isomer required a different process than those encountered when the substance was first scheduled, and was believed less potent than the ''cis'' isomer with a much lower abuse potential. However, studies revealing the abuse potential of the 'trans' isomer{{citation needed|date=December 2014}}, coupled with the development of new clandestine synthetic methods that would produce the ''trans''{{citation needed|date=December 2014}} created a potential loophole in the law, which covered only the 'cis' isomer. To clarify the situation, the US Drug Enforcement Administration published a paper in its DEA Microgram Journal, regarding interpretation of the relevant statutory law as it relates to the status of ''trans''-4-methylaminorex. In summary, according to this non-legally binding decision, ''trans''-4-methylaminorex is not currently a controlled substance, but a potential analogue. In fact, the report explicitly states: The United States Drug Enforcement Administration has the following opinion on the legality of the positional isomer "trans"-4-methylaminorex, which, unlike its 'cis' isomer was never placed in any schedule under the Controlled Substances Act. However, the opinion does say that the agency considers the substance a potential controlled substance analogue, making the substance identical to a Schedule I substance if intended for human consumption, according to the Federal Analogue Act. The report gives an account of a successful conviction under the Federal Analogue Act of an offense involving the ''trans'' isomer.<ref name="Synthesis of trans-4-Methylaminorex from Norephedrine and Potassium Cyanate (DEA Microgram Journal)">[http://www.dea.gov/programs/forensicsci/microgram/journal_v3_num34/journal_v3_num34_pg6.html Synthesis of trans-4-Methylaminorex from Norephedrine and Potassium Cyanate (DEA Microgram Journal)]</ref> | |||
**'''Florida''': "2-Amino-4-methyl-5-phenyl-2-oxazoline (4-methylaminorex)" and "any material, compound, mixture, or preparation that contains any quantity of" it "or that contains any of [its] salts, isomers, including optical, positional, or geometric isomers, and salts of isomers, if the existence of such salts, isomers, and salts of isomers is possible" is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.<ref name="Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL">[http://leg.state.fl.us/statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL]</ref> | |||
==See also== | ==See also== | ||
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==External links== | ==External links== | ||
*[ | *[https://en.wikipedia.org/wiki/4-Methylaminorex 4-Methylaminorex (Wikipedia)] | ||
*[https://erowid.org/chemicals/4_methylaminorex/4_methylaminorex.shtml 4-Methylaminorex (Erowid Vault)] | |||
*[https://isomerdesign.com/PiHKAL/explore.php?id=562 4-Methylaminorex (Isomer Design)] | |||
==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Articles in talk page]] | |||
[[Category:Psychoactive substance]] | [[Category:Psychoactive substance]] | ||
[[Category:Research chemical]] | [[Category:Research chemical]] | ||