Talk:25E-NBOH: Difference between revisions

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==Chemistry==

25E-NBOH or 2C-E-NBOH, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as [[2C-E]]. ~~25C~~-NBOH is a substituted phenethylamine with methoxy groups CH3O- attached to carbons R2 and R5 ~~as well as~~ an ~~bromine atom attached~~ to carbon R4. It differs from [[2C-E]] structurally through a substitution on the amine (NH2) with a 2-hydroxybenzyl (BOH) group. ~~25C~~-NBOH shares this 2-hydroxybenzyl substitution with other chemicals of the NBOH family. This NBOH addition is comprised of a hydroxy ether OH- bound to a benzene ring at R2.

25E-NBOH or 2C-E-NBOH, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as [[2C-E]]. 25E-NBOH is a substituted phenethylamine with methoxy groups CH3O- attached to carbons R2 and R5 and an ethyl chain bound to carbon R4 of the phenyl ring. It differs from [[2C-E]] structurally through a substitution on the amine (NH2) with a 2-hydroxybenzyl (BOH) group. 25E-NBOH shares this 2-hydroxybenzyl substitution with other chemicals of the NBOH family. This NBOH addition is comprised of a hydroxy ether OH- bound to a benzene ring at R2.

==Pharmacology==

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*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 25E-NBOH is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the user to move unless they choose to do so. For others, however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of [[MDMA]] and traditional stimulants such as [[amphetamine]].

*'''[[Effect::Perception of bodily lightness]]''' ~~- In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.~~

*'''[[Effect::Perception of bodily lightness]]'''

*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" itself can be described as a mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of [[Physical euphoria|euphoria]] that become longer and more drawn out proportional to the dosage consumed.

*'''[[Effect::Spontaneous physical sensations]]'''

*'''[[Effect::Mouth numbing]]''' - Assuming the substance has been taken [[sublingual|sublingually]], the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very distinct feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed.

*'''[[Effect::Nausea]]''' - As the user begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, although nausea usually disappears when the user has vomited or the trip fully set in. In comparison to other psychedelics such as [[psilocin]], [[LSD]], [[2C-E]] and [[2C-I]], this could actually be considered very mild in its intensity.

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====Hallucinatory states====

~~These effects include:~~

*'''[[Effect::Transformations]]'''

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|{{effects/cognitive|

The ~~cognitive effects~~ of 25E-NBOH ~~are~~ described by many as ~~notably light in comparison to the classical [[psychedelics]]. It~~ is ~~not uncommon for people to report feeling that their thought stream has maintained general normality~~ in its ~~specific style throughout low~~ to ~~moderate~~ dosages. ~~At high dosages, however, strong to overwhelming cognitive alterations become present, which can lead to states~~ of [[~~confusion]], [[amnesia~~]]~~, and general sensory overload~~.

The head space of 25E-NBOH is described by many as one which is both insightful and relatively unaltered in its thought processes even at moderate to high dosages. Some users suggest that 25E-NBOH may be even more clearheaded than other drugs of the [[25x-NBOH]] class.

The most prominent of these cognitive effects generally include:

*'''[[Effect::Analysis enhancement]]'''

*'''[[Effect::Analysis enhancement]]''' - This component is introspection dominant and consistently manifested only in the context of a non-social setting in which the user is alone.

*'''[[Effect::Thought acceleration]]'''

*'''[[Effect::Conceptual thinking]]'''

*'''[[Effect::Anxiety]]''' & '''[[Effect::Paranoia]]'''

**'''[[Effect::Feelings of impending doom]]'''

*'''[[Effect::Empathy, affection, and sociability enhancement]]'''

*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings are a little weaker and less sharp than those produced by substances such as MDMA and 2C-B but still often prove strong enough to provide long-lasting therapeutic effects.

*'''[[Effect::Memory suppression]]'''

**'''[[Effect::Ego death]]'''

@@ Line 15: / Line 15: @@
 ==Chemistry==
-E-NBOH or 2C-E-NBOH, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as [[2C-E]]. 25C-NBOH is a substituted phenethylamine with methoxy groups CH<sub>3</sub>O- attached to carbons R<sub>2</sub> and R<sub>5</sub> as well as an bromine atom attached to carbon R<sub>4</sub>. It differs from [[2C-E]] structurally through a substitution on the amine (NH<sub>2</sub>) with a 2-hydroxybenzyl (BOH) group. 25C-NBOH shares this 2-hydroxybenzyl substitution with other chemicals of the NBOH family. This NBOH addition is comprised of a hydroxy ether OH- bound to a benzene ring at R<sub>2</sub>.
+E-NBOH or 2C-E-NBOH, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as [[2C-E]]. 25E-NBOH is a substituted phenethylamine with methoxy groups CH<sub>3</sub>O- attached to carbons R<sub>2</sub> and R<sub>5</sub> and an ethyl chain bound to carbon R<sub>4</sub> of the phenyl ring. It differs from [[2C-E]] structurally through a substitution on the amine (NH<sub>2</sub>) with a 2-hydroxybenzyl (BOH) group. 25E-NBOH shares this 2-hydroxybenzyl substitution with other chemicals of the NBOH family. This NBOH addition is comprised of a hydroxy ether OH- bound to a benzene ring at R<sub>2</sub>.
 ==Pharmacology==
@@ Line 30: / Line 30: @@
 *'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 25E-NBOH is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the user to move unless they choose to do so. For others, however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of [[MDMA]] and traditional stimulants such as [[amphetamine]].
-*'''[[Effect::Perception of bodily lightness]]''' - In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
+*'''[[Effect::Perception of bodily lightness]]'''
-*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" itself can be described as a mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of [[Physical euphoria|euphoria]] that become longer and more drawn out proportional to the dosage consumed.
+*'''[[Effect::Spontaneous physical sensations]]'''
 *'''[[Effect::Mouth numbing]]''' - Assuming the substance has been taken [[sublingual|sublingually]], the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very distinct feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed.
 *'''[[Effect::Nausea]]''' - As the user begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, although nausea usually disappears when the user has vomited or the trip fully set in. In comparison to other psychedelics such as [[psilocin]], [[LSD]], [[2C-E]] and [[2C-I]], this could actually be considered very mild in its intensity.
@@ Line 89: / Line 89: @@
 ====Hallucinatory states====
-These effects include:
 *'''[[Effect::Transformations]]'''
@@ Line 99: / Line 97: @@
 |{{effects/cognitive|
-The cognitive effects of 25E-NBOH are described by many as notably light in comparison to the classical [[psychedelics]]. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages, however, strong to overwhelming cognitive alterations become present, which can lead to states of [[confusion]], [[amnesia]], and general sensory overload.
+    The head space of 25E-NBOH is described by many as one which is both insightful and relatively unaltered in its thought processes even at moderate to high dosages. Some users suggest that 25E-NBOH may be even more clearheaded than other drugs of the [[25x-NBOH]] class.
 The most prominent of these cognitive effects generally include:
-*'''[[Effect::Analysis enhancement]]'''
+*'''[[Effect::Analysis enhancement]]''' - This component is introspection dominant and consistently manifested only in the context of a non-social setting in which the user is alone.
 *'''[[Effect::Thought acceleration]]'''
 *'''[[Effect::Conceptual thinking]]'''
 *'''[[Effect::Anxiety]]''' & '''[[Effect::Paranoia]]'''
 **'''[[Effect::Feelings of impending doom]]'''
-*'''[[Effect::Empathy, affection, and sociability enhancement]]'''
+*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings are a little weaker and less sharp than those produced by substances such as MDMA and 2C-B but still often prove strong enough to provide long-lasting therapeutic effects.
 *'''[[Effect::Memory suppression]]'''
 **'''[[Effect::Ego death]]'''