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{{SummarySheet}}
{{SummarySheet}}
{{SubstanceBox/25C-NBOH}}
{{SubstanceBox/Example}}


'''25E-NBOH''' (also known as '''2C-E-NBOH''' and '''NBOH-2C-E''') is novel synthetic [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] chemical class that produces an array of visually-dominant and [[stimulating]] [[psychedelic]] effects when [[Routes of administration|administered]].
'''25E-NBOH''' (also known as '''2C-E-NBOH''' and '''NBOH-2C-E''') is novel synthetic [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] chemical class that produces an array of visually-dominant and [[stimulating]] [[psychedelic]] effects when [[Routes of administration|administered]].
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==Chemistry==
==Chemistry==
25E-NBOH or 2C-E-NBOH, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as [[2C-E]]. 25C-NBOH is a substituted phenethylamine with methoxy groups CH<sub>3</sub>O- attached to carbons R<sub>2</sub> and R<sub>5</sub> as well as an bromine atom attached to carbon R<sub>4</sub>. It differs from [[2C-E]] structurally through a substitution on the amine (NH<sub>2</sub>) with a 2-hydroxybenzyl (BOH) group. 25C-NBOH shares this 2-hydroxybenzyl substitution with other chemicals of the NBOH family. This NBOH addition is comprised of a hydroxy ether OH- bound to a benzene ring at R<sub>2</sub>.
25E-NBOH or 2C-E-NBOH, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as [[2C-E]]. 25E-NBOH is a substituted phenethylamine with methoxy groups CH<sub>3</sub>O- attached to carbons R<sub>2</sub> and R<sub>5</sub> and an ethyl chain bound to carbon R<sub>4</sub> of the phenyl ring. It differs from [[2C-E]] structurally through a substitution on the amine (NH<sub>2</sub>) with a 2-hydroxybenzyl (BOH) group. 25E-NBOH shares this 2-hydroxybenzyl substitution with other chemicals of the NBOH family. This NBOH addition is comprised of a hydroxy ether OH- bound to a benzene ring at R<sub>2</sub>.


==Pharmacology==
==Pharmacology==
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*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 25E-NBOH is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the user to move unless they choose to do so. For others, however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of [[MDMA]] and traditional stimulants such as [[amphetamine]].
*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 25E-NBOH is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the user to move unless they choose to do so. For others, however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of [[MDMA]] and traditional stimulants such as [[amphetamine]].
*'''[[Effect::Perception of bodily lightness]]''' - In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
*'''[[Effect::Perception of bodily lightness]]'''
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" itself can be described as a mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of [[Physical euphoria|euphoria]] that become longer and more drawn out proportional to the dosage consumed.
*'''[[Effect::Spontaneous physical sensations]]'''
*'''[[Effect::Mouth numbing]]''' - Assuming the substance has been taken [[sublingual|sublingually]], the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very distinct feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed.  
*'''[[Effect::Mouth numbing]]''' - Assuming the substance has been taken [[sublingual|sublingually]], the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very distinct feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed.  
*'''[[Effect::Nausea]]''' - As the user begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, although nausea usually disappears when the user has vomited or the trip fully set in. In comparison to other psychedelics such as [[psilocin]], [[LSD]], [[2C-E]] and [[2C-I]], this could actually be considered very mild in its intensity.
*'''[[Effect::Nausea]]''' - As the user begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, although nausea usually disappears when the user has vomited or the trip fully set in. In comparison to other psychedelics such as [[psilocin]], [[LSD]], [[2C-E]] and [[2C-I]], this could actually be considered very mild in its intensity.
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====Hallucinatory states====
====Hallucinatory states====
25E-NBOH is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very different and inconsistent in comparison to other more commonly used psychedelics such as [[psilocin]], [[2C-E]] and [[DMT]].


These effects include:


*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Machinescapes]]''' - This component is an uncommon effect that typically only occurs at very strong to heavy doses. It also tends to be accompanied by overwhelming if not dangerous physical and cognitive effects.
*'''[[Effect::Machinescapes]]''' - This component is an uncommon effect that typically only occurs at very strong to heavy doses.
*'''[[Effect::Internal hallucination]]''' - (''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]''). These are more common within dark environments and can be described as lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
*'''[[Effect::Internal hallucination]]''' - (''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')


}}
}}
|{{effects/cognitive|
|{{effects/cognitive|


The cognitive effects of 25E-NBOH are described by many as notably light in comparison to the classical [[psychedelics]]. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages, however, strong to overwhelming cognitive alterations become present, which can lead to states of [[confusion]], [[amnesia]], and general sensory overload.  
    The head space of 25E-NBOH is described by many as one which is both insightful and relatively unaltered in its thought processes even at moderate to high dosages. Some users suggest that 25E-NBOH may be even more clearheaded than other drugs of the [[25x-NBOH]] class.


The most prominent of these cognitive effects generally include:
The most prominent of these cognitive effects generally include:


*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Analysis enhancement]]''' - This component is introspection dominant and consistently manifested only in the context of a non-social setting in which the user is alone.
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Anxiety]]''' & '''[[Effect::Paranoia]]'''  
*'''[[Effect::Anxiety]]''' & '''[[Effect::Paranoia]]'''  
**'''[[Effect::Feelings of impending doom]]'''
**'''[[Effect::Feelings of impending doom]]'''
*'''[[Effect::Empathy, affection, and sociability enhancement]]'''
*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings are a little weaker and less sharp than those produced by substances such as MDMA and 2C-B but still often prove strong enough to provide long-lasting therapeutic effects.
*'''[[Effect::Memory suppression]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
**'''[[Effect::Ego death]]'''
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{{effects/multisensory|
{{effects/multisensory|


*'''[[Effect::Dosage independent intensity]]''' - While the reasons for this are not understood, many reports suggest that this substance can produce unexpectedly strong or weak effects even when taken at the seemingly same dose in an unpredictable manner.{{citation needed}} This may contribute to the relative risk it is poses compared to most other psychedelics.
*'''[[Effect::Dosage independent intensity]]''' -
*'''[[Effect::Synaesthesia]]''' - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
*'''[[Effect::Synaesthesia]]''' - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.


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Additional experience reports can be found here:
Additional experience reports can be found here:


*[https://www.erowid.org/experiences/subs/exp_25CNBOH.shtml Erowid Experience Vaults: 25C-NBOH]
*[https://www.erowid.org/experiences/subs/exp_25ENBOH.shtml Erowid Experience Vaults: 25E-NBOH]


==Toxicity and harm potential==
==Toxicity and harm potential==
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===Tolerance and addiction potential===
===Tolerance and addiction potential===
25C-NBOH is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  
25E-NBOH is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  


Tolerance to the effects of 25C-NBOH is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back at baseline (in the absence of further consumption). 25C-NBOH presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25C-NBOH all psychedelics will have a reduced effect.
Tolerance to the effects of 25E-NBOH is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back at baseline (in the absence of further consumption). 25E-NBOH presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25E-NBOH all psychedelics will have a reduced effect.


===Dangerous interactions===
===Dangerous interactions===
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