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Talk:Ethylcathinone: Difference between revisions
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{{SubstanceBox/Ethylcathinone}} | {{SubstanceBox/Ethylcathinone}} | ||
'''Ethylcathinone''', '''ethylpropion''' or '''ETH-CAT''', is a [[psychoactive class::stimulant]] drug of the phenethylamine, [[chemical class::amphetamine]], and [[Substituted cathinone|cathinone]] chemical classes. It is an active metabolite of the prodrug diethylcathinone and is responsible for its effects. Ethcathinone has been identified as an ingredient in both quasi-legal "party pills", and, along with mephedrone, has also been reported as having been sold as "ecstasy"<ref>Police warn of potentially fatal 'fake ecstasy' | http://www.abc.net.au/news/2008-06-17/police-warn-of-potentially-fatal-fake-ecstasy/2475270</ref> | |||
'''Ethylcathinone''', '''ethylpropion''' or '''ETH-CAT''', is a [[psychoactive class::stimulant]] drug of the phenethylamine, [[chemical class::amphetamine]], and cathinone chemical classes. It is an active metabolite of the prodrug diethylcathinone and is responsible for its effects. | |||
It is rarely found on the streets, but is sold as a grey market [[research chemical]] through online vendors.<ref>Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs) (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15639609</ref><ref>Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20074881</ref> | It is rarely found on the streets, but is sold as a grey market [[research chemical]] through online vendors.<ref>Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs) (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15639609</ref><ref>Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20074881</ref> | ||
==Chemistry== | ==Chemistry== | ||
{{chemistry}} | |||
Ethylcathinone is a simple structural modification of [[mephedrone]] where homologation of the N-methyl substituent to an N-ethyl group occurs. Aromatic substituents, similar to those for the [[amphetamine]] analogs, have been incorporated into cathinone and mephedrone. | |||
==Pharmacology== | ==Pharmacology== | ||
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===Cognitive effects=== | ===Cognitive effects=== | ||
The cognitive effects of ethylcathinone can be broken down into several components which intensify proportional to dosage. The general head space of ethylcathinone is described by many as one of mental stimulation coupled | The cognitive effects of ethylcathinone can be broken down into several components which intensify proportional to dosage. The general head space of ethylcathinone is described by many as one of mental stimulation coupled with mild euphoria, less present than that of [[amphetamine]], even at higher doses. | ||
*'''[[Effect::Cognitive euphoria]]''' | *'''[[Effect::Cognitive euphoria]]''' | ||
*'''[[Effect::Thought acceleration]]''' | *'''[[Effect::Thought acceleration]]''' | ||
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==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
{{ | {{Further|Research chemicals#Toxicity and harm potential}} | ||
The toxicity and long-term health effects of recreational ethylcathinone use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because ethylcathinone has very little history of human usage. Anecdotal evidence from people who have tried ethylcathinone within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). Others have commented that its d-isomer form is virtually similar to the effects of d-[[amphetamine]], and thus far little has been shown to give reason to suspect that its toxicity is radically different (though future evidence to the contrary may prove otherwise). | The toxicity and long-term health effects of recreational ethylcathinone use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because ethylcathinone has very little history of human usage. Anecdotal evidence from people who have tried ethylcathinone within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). Others have commented that its d-isomer form is virtually similar to the effects of d-[[amphetamine]], and thus far little has been shown to give reason to suspect that its toxicity is radically different (though future evidence to the contrary may prove otherwise). | ||
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As with other [[stimulant]]s, ethylcathinone may also possess addiction reinforcing properties. Compared with other stimulants, however chronic use of ethylcathinone can be considered only [[Addiction potential::mildly addictive with a comparatively low potential for abuse]]. Early studies demonstrate ethylcathinone suppresses cocaine self-administration in rhesus monkeys, without the adverse effects associated with older phenylethylamine 5-HT releasers (e.g., fenfluramine) and DA releasers (e.g., amphetamine). Despite this, ethylcathinone may still be capable of causing psychological dependence among certain users. | As with other [[stimulant]]s, ethylcathinone may also possess addiction reinforcing properties. Compared with other stimulants, however chronic use of ethylcathinone can be considered only [[Addiction potential::mildly addictive with a comparatively low potential for abuse]]. Early studies demonstrate ethylcathinone suppresses cocaine self-administration in rhesus monkeys, without the adverse effects associated with older phenylethylamine 5-HT releasers (e.g., fenfluramine) and DA releasers (e.g., amphetamine). Despite this, ethylcathinone may still be capable of causing psychological dependence among certain users. | ||
Tolerance to many of the effects of ethylcathinone [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 10 days]] to be back at baseline (in the absence of further consumption). Ethylcathinone presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic [[stimulant]]s]], meaning that after the consumption of ethylcathinone all [[stimulant]]s will have a reduced effect. | |||
Tolerance to many of the effects of | |||
===Psychosis=== | ===Psychosis=== | ||
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{{DangerousInteractions/Intro}} | {{DangerousInteractions/Intro}} | ||
{{DangerousInteractions/MAOI|nt=dopamine}} | {{DangerousInteractions/MAOI|nt=dopamine}} | ||
*'''[[Stimulants]]''' - | *'''[[Stimulants]]''' - Ethylcathinone can be potentially dangerous in combination with other [[stimulant]]s as it can [[increased heart rate|increase one's heart rate]] and [[increased blood pressure|blood pressure]] to dangerous levels. | ||
{{DangerousInteractions/Stimulants}} | {{DangerousInteractions/Stimulants}} | ||
*'''[[MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with [[amphetamine]]s. | *'''[[MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with [[amphetamine]]s. | ||
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*[[Stimulants]] | *[[Stimulants]] | ||
*[[Amphetamine]] | *[[Amphetamine]] | ||
*[[Substituted cathinone|Cathinone]] | |||
*[[Methamphetamine]] | *[[Methamphetamine]] | ||
*[[2-FMA]] | *[[2-FMA]] | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/Ethcathinone Ethcathinone (Wikipedia)] | *[https://en.wikipedia.org/wiki/Ethcathinone Ethcathinone (Wikipedia)] | ||
*[https://erowid.org/chemicals/ethylcathinone/ethylcathinone.shtml Ethcathinone (Erowid)] | *[https://erowid.org/chemicals/ethylcathinone/ethylcathinone.shtml Ethcathinone (Erowid Vault)] | ||
*[ | *[https://isomerdesign.com/PiHKAL/explore.php?id=2019 Ethylcathinone (Isomer Design)] | ||
==References== | ==References== | ||
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[[Category:Amphetamine]] | [[Category:Amphetamine]] | ||
[[Category:Stimulant]] | [[Category:Stimulant]] | ||
[[Category:Cathinone]] | |||
[[Category:Nootropic]] | [[Category:Nootropic]] | ||
{{#set:Featured=true}} | {{#set:Featured=true}} | ||