Proscaline

Proscaline
Chemical Nomenclature
Common names	Proscaline
Substitutive name	4-propyloxy-3,5-dimethoxyphenethylamine
Class Membership
Psychoactive class	Psychedelic
Chemical class	Phenethylamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 10 mg Light 15 - 30 mg Common 30 - 40 mg Strong 40 - 60 mg Heavy 60 mg + Duration Total 8 - 12 hours Onset 30 - 60 minutes After effects 3 - 5 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Summary sheet: Proscaline

Proscaline (also known as 4-propyloxy-3,5-dimethoxyphenethylamine) is a psychedelic of the phenethylamine class. It has structural and pharmacological properties similar to its parent drug mescaline as well as to its analogs such as isoproscaline, escaline and allylescaline.

Proscaline was first synthesized by Alexander Shulgin and later documented in his book "PiHKAL: A Chemical Love Story". In modern times it is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors. It is relatively obscure and has only a short history of human use.

Chemistry

Proscaline, or 3,5-dimethoxy-4-propyloxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino -NH2 group through an ethyl chain. Proscaline contains two methoxy functional groups CH3O- which are attached to carbons R3 and R5 as well as an additional propyloxy group at carbon R4 of the phenyl ring. Proscaline is the 4-propyloxy analog of mescaline, which means it has one additional carbon at the alkyloxy group than escaline, another closely related mescaline analog.

Pharmacology

Further information: Serotonergic psychedelic

Proscaline's psychedelic effects are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• Spontaneous tactile sensations
• Increased heart rate
• Nausea
• Pupil dilation

Cognitive effects

• Conceptual thinking
• Cognitive euphoria
• Delusions
• Emotion enhancement
• Immersion enhancement
• Increased music appreciation
• Memory suppression
  • Ego death
• Novelty enhancement
• Personal bias suppression
• Thought loops
• Time distortion
• Unity and interconnectedness

Visual effects

Enhancements

• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement

Distortions

• Drifting (melting, breathing, morphing and flowing)
• Colour shifting
• Depth perception distortions
• Perspective distortions
• Symmetrical texture repetition
• Tracers
• After images
• Brightness alteration
• Diffraction

Geometry

Hallucinatory states

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Toxicity and harm potential

Further information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational proscaline use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried proscaline within the psychedelic community suggests that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

Proscaline is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of proscaline are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). proscaline presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of proscaline all psychedelics will have a reduced effect.

Legal issues

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

• United States: Proscaline is uncontrolled in the United States, but could be considered an analog of mescaline under the Federal Analog Act.
• United Kingdom: Proscaline is a Class A controlled substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act of 1971.

See also

• Responsible use
• Psychoactive substance index
• Psychedelics
• Phenethylamines
• Mescaline
• Escaline

External links

• Proscaline (Wikipedia)
• Proscaline (PiHKAL)
• Proscaline (Bluelight)
• proscaline (Tripsit)